Auditory N1-P2 Cortical Event Related Potentials in Auditory Neuropathy Spectrum Disorder Patients

Abdeltawwab, Mohamed M.

doi:10.5152/iao.2014.104

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…To our knowledge, there are no published reports that discuss eliciting P300 potential in the presence of noise in individuals with ANSD. In the majority of the studies, researchers have recorded P1-N1-P2 potentials 14 15 36 49 50 , mismatch negativity 16 17 and P300 34 37 38 in quiet condition for individuals with ANSD. The result of the previous study investigating P300 response in individuals with ANSD 34 37 showed prolongation in latency of P300 response, reduction in amplitude of P300 response, prolonged RT and poorer sensitivity in quiet condition for different stimuli in individuals with ANSD compared with individuals with normal hearing sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Effect of Quiet and Noise on P300 Response in Individuals with Auditory Neuropathy Spectrum Disorder

Apeksha

Kumar

2020

Int Arch Otorhinolaryngol

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Introduction Auditory neuropathy spectrum disorder (ANSD) is a clinical condition in which individuals have normal cochlear responses and abnormal neural responses. There is a lack of evidence in the literature regarding the neural discrimination skill in individuals with ANSD, especially when the signal is presented in the presence of noise. Objectives The present study was performed with the aim to investigate auditory discrimination skill, in quiet and in the presence of noise, in individuals with ANSD and to compare the findings with normal-hearing individuals. Methods A total of 30 individuals with normal hearing sensitivity and 30 individuals with ANSD in the age range of 15 to 55 years old, with the mean age of 27.86 years old, were the participants. P300 response was recorded from both groups using syllable pairs /ba/-/da/ in oddball paradigm and the syllable /da/ in repetitive paradigm in quiet and at +10 dB signal-to-noise ratio (SNR). Results There was significant prolongation in latency and reaction time, and reduction in amplitude of P300 response and sensitivity in both groups with the addition of noise. The topographic pattern analysis showed activation of the central-parietal-occipital region of the brain in individuals with ANSD, whereas activation of the central-parietal region was observed in individuals with normal hearing. The activation was more diffused in individuals with ANSD compared with that of individuals with normal hearing. Conclusion The individuals with ANSD showed a significantly more adverse effect of noise on the neural discrimination skill than the normal counterpart.

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Section: Discussionmentioning

confidence: 99%

Effect of Quiet and Noise on P300 Response in Individuals with Auditory Neuropathy Spectrum Disorder

Apeksha

Kumar

2020

Int Arch Otorhinolaryngol

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“…Speech identification scores were correlated with the amplitudes of N1-P2 but not with their latencies. Abdeltawwab [14] recorded N1-P2 complexes in 13 of 16 subjects and reported that latency was prolonged and the N1-P2 amplitudes were reduced in individuals with auditory neuropathy. Furthermore, he reported that poorer speech discrimination scores were associated with decreased amplitude and prolonged N1-P2 latencies in his subjects.…”

Section: Introductionmentioning

confidence: 99%

Cortical Evoked Potentials and Hearing Aids in Individuals with Auditory Dys-Synchrony

Yuvaraj

Mohan²

2016

Int Adv Otol

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OBJECTIVE:The purpose of the present study was to investigate the relationship between cortical processing of speech and benefit from hearing aids in individuals with auditory dys-synchrony. MATERIALS and METHODS:Data were collected from 38 individuals with auditory dys-synchrony. Participants were selected based on hearing thresholds, middle ear reflexes, otoacoustic emissions, and auditory brain stem responses. Cortical-evoked potentials were recorded for click and speech. Participants with auditory dys-synchrony were fitted with bilateral multichannel wide dynamic range compression hearing aids. Aided and unaided speech identification scores for 40 words were obtained for each participant. RESULTS:Hierarchical cluster analysis using Ward's method clearly showed four subgroups of participants with auditory dys-synchrony based on the hearing aid benefit score (aided minus unaided speech identification score). The difference in the mean aided and unaided speech identification scores was significantly different in participants with auditory dys-synchrony. However, the mean unaided speech identification scores were not significantly different between the four subgroups. The N2 amplitude and P1 latency of the speech-evoked cortical potentials were significantly different between the four subgroups formed based on hearing aid benefit scores. CONCLUSION:The results indicated that subgroups of individuals with auditory dys-synchrony who benefit from hearing aids exist. Individuals who benefitted from hearing aids showed decreased N2 amplitudes compared with those who did not. N2 amplitude is associated with greater suppression of background noise while processing speech.

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Cortical processing of speech in individuals with auditory neuropathy spectrum disorder

Apeksha

Uppunda

2018

Eur Arch Otorhinolaryngol

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Auditory N1-P2 Cortical Event Related Potentials in Auditory Neuropathy Spectrum Disorder Patients

Cited by 5 publications

References 16 publications

Effect of Quiet and Noise on P300 Response in Individuals with Auditory Neuropathy Spectrum Disorder

Effect of Quiet and Noise on P300 Response in Individuals with Auditory Neuropathy Spectrum Disorder

Cortical Evoked Potentials and Hearing Aids in Individuals with Auditory Dys-Synchrony

Cortical processing of speech in individuals with auditory neuropathy spectrum disorder

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