Auditory neuropathy/dyssynchrony as a cause of failed neonatal hearing screening

Maris, Mieke; Venstermans, Caroline; Boudewyns, An

doi:10.1016/j.ijporl.2011.04.012

Cited by 39 publications

(31 citation statements)

References 17 publications

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“…Maris et al [13] performed a retrospective analysis on the prevalence of auditory neuropathy/dyssynchrony in a population of infants referred after failed a neonatal hearing screening. This is a neuropathy of the cochlear nerve in combination with a general peripheral neuropathy.…”

Section: Discussionmentioning

confidence: 99%

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Is Hearing Loss in Infants Associated With Risk Factors? Evaluation of the Frequency of Risk Factors

Karaca

Oysu

Toros

et al. 2014

Clin Exp Otorhinolaryngol

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ObjectivesTo evaluate the frequency of risk factors and their influence on the evoked otoacoustic emission (OAE) of infants.MethodsAll newborns between November 2009 and June 2012 in Haydarpaşa Numune Education and Research Hospital were tested on distortion evoked OAE screening test. Total of 2,284 infants were examined. Sex, maternal infectious disease, birth type (vaginal birth or caesarean sectio), birth weight, familial hearing loss, intermarriage of parents, hyperbilirubinemia, intensive care were analyzed as risk factors.ResultsTotal of 2,284 neonates were screened (1,220 males and 1,064 females) for the presence of OAE in both ears. Vaginal delivery, maternal infections during pregnancy, intermarriage of parents relative, low birth weight(<1,500 g) are related risk factors to failure of screening with OAE in our study. There was no statistically significant difference in sex ratios, birth weight, familial hearing loss, hyperbilirubinemia, and intensive care stay.ConclusionRisk factors are only as useful as their predictive power. Not enough is known about which risk factors are relevant, which babies have the risk factors, or which babies will fail to attend follow-up, the effectiveness of targeted hearing loss testing is questionable at this point in time. A system needs to be developed to clarify which risk factors are discoverable, predictive and useful.

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Section: Discussionmentioning

confidence: 99%

“…This is a neuropathy of the cochlear nerve in combination with a general peripheral neuropathy. Normal TEOAE in combination with an absent or severely abnormal ABR are crucial for diagnosis [13]. Because of this they concluded that ABR must be the method of choice for neonatal hearing screening.…”

Section: Discussionmentioning

confidence: 99%

Is Hearing Loss in Infants Associated With Risk Factors? Evaluation of the Frequency of Risk Factors

Karaca

Oysu

Toros

et al. 2014

Clin Exp Otorhinolaryngol

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“…It is estimated that 5–15% of all children with sensorineural hearing loss (SNHL) exhibit symptoms of ANSD (Uus & Bamford, 2006; Kirkim et al, 2008; Talaat et al, 2009; Berlin et al, 2010; Maris et al, 2011; Roush et al, 2011; Bielecki et al, 2012; Mittal et al, 2012). The majority of these individuals present with bilateral ANSD.…”

Section: 1 Auditory Neuropathy Spectrum Disorder (Ansd): Descriptiomentioning

confidence: 99%

“…CND is characterized by hypoplasia or aplasia of the VIII nerve (Buchman et al, 2006; McClay et al, 2008; Huang et al, 2010; Roche et al, 2010; Maris et al, 2011). ANSD and CND are particularly related because of the poor neural connectivity and conduction secondary to reduced functional nerve fibers found in CND (Buchman et al, 2006; Walton et al, 2008).…”

Section: 1 Auditory Neuropathy Spectrum Disorder (Ansd): Descriptiomentioning

confidence: 99%

Cortical development and neuroplasticity in Auditory Neuropathy Spectrum Disorder

Sharma

Cardon

2015

Hearing Research

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Cortical development is dependent to a large extent on stimulus-driven input. Auditory Neuropathy Spectrum Disorder (ANSD) is a recently described form of hearing impairment where neural dys-synchrony is the predominant characteristic. Children with ANSD provide a unique platform to examine the effects of asynchronous and degraded afferent stimulation on cortical auditory neuroplasticity and behavioral processing of sound. In this review, we describe patterns of auditory cortical maturation in children with ANSD. The disruption of cortical maturation that leads to these various patterns includes high levels of intra-individual cortical variability and deficits in cortical phase synchronization of oscillatory neural responses. These neurodevelopmental changes, which are constrained by sensitive periods for central auditory maturation, are correlated with behavioral outcomes for children with ANSD. Overall, we hypothesize that patterns of cortical development in children with ANSD appear to be markers of the severity of the underlying neural dys-synchrony, providing prognostic indicators of success of clinical intervention with amplification and/or electrical stimulation.

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“…Auditory Neuropathy Spectrum Disorder (ANSD) is a relatively recently described disorder (Starr et al, 1991, 1996), which has been shown to affect approximately 10-15% of all children with sensorineural hearing loss (Uus & Bamford, 2006; Kirkim et al, 2008; Talaat et al, 2009; Berlin et al, 2010; Maris et al, 2011; Roush et al, 2011; Bielecki, Horbuleweicz, & Wolan, 2012; Mittal et al, 2012). Diagnosis of ANSD has become all but routine in many audiology clinics throughout the world.…”

Section: Introductionmentioning

confidence: 99%

Central auditory maturation and behavioral outcome in children with auditory neuropathy spectrum disorder who use cochlear implants

Cardon

Sharma

2013

International Journal of Audiology

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Objective We examined cortical auditory development and behavioral outcomes in children with ANSD fitted with cochlear implants (CI). Design Cortical maturation, measured by P1 cortical auditory evoked potential (CAEP) latency, was regressed against scores on the Infant Toddler Meaningful Auditory Integration Scale (IT-MAIS). Implantation age was also considered in relation to CAEP findings. Study Sample Cross-sectional and longitudinal samples of 24 and 11 children, respectively, with ANSD fitted with CIs. Result P1 CAEP responses were present in all children after implantation, though previous findings suggest that only 50-75% of ANSD children with hearing aids show CAEP responses. P1 CAEP latency was significantly correlated with participants' IT-MAIS scores. Furthermore, more children implanted before age two years showed normal P1 latencies, while those implanted later mainly showed delayed latencies. Longitudinal analysis revealed that most children showed normal or improved cortical maturation after implantation. Conclusion Cochlear implantation resulted in measureable cortical auditory development for all children with ANSD. Children fitted with CIs under age two years were more likely to show age-appropriate CAEP responses within 6 months after implantation, suggesting a possible sensitive period for cortical auditory development in ANSD. That CAEP responses were correlated with behavioral outcome highlights their clinical decision-making utility.

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Auditory neuropathy/dyssynchrony as a cause of failed neonatal hearing screening

Cited by 39 publications

References 17 publications

Is Hearing Loss in Infants Associated With Risk Factors? Evaluation of the Frequency of Risk Factors

Is Hearing Loss in Infants Associated With Risk Factors? Evaluation of the Frequency of Risk Factors

Cortical development and neuroplasticity in Auditory Neuropathy Spectrum Disorder

Central auditory maturation and behavioral outcome in children with auditory neuropathy spectrum disorder who use cochlear implants

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