Auditory P300 event related potential and serotonin reuptake inhibitor treatment in obsessive-compulsive disorder patients

Sanz, Marta; Molina, Vicente; Martı́n-Loeches, Manuel; Calcedo, Alfredo; Rubia, Francisco J.

doi:10.1016/s0165-1781(00)00250-x

Cited by 62 publications

(63 citation statements)

References 30 publications

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“…Johannes and collaborators (1997) observed a target P300 amplitude reduction in groups characterized as «pure» GTS, but who actually showed a clinical profile very similar to our GTS+OCS group. Similar results were previously obtained with pure OCD groups (Beech et al, 1983;Ciesielski et al, 1981;Malloy et al, 1989;Sanz et al, 2001;Towey et al, 1994). Nonetheless, these earlier studies didn't mention the relationship between P300 component and symptom intensity.…”

Section: Influence Of Obsessive-compulsive Symptoms On Erp Profilesupporting

confidence: 83%

“…Wolach and Pratt, 2001). In previous studies, a reduction in P300 amplitude has been consistently observed in GTS (Johannes et al, 1997(Johannes et al, , 2001b and in OCD (Kim et al, 2003;Miyata et al, 1998;Sanz et al, 2001;Towey et al, 1994), pointing towards a decrease in memory updating processes in both disorders. Nevertheless, these P300 patterns were elicited in slightly different experimental procedures, so nuancing homogeneous interpretation of their functional significance across groups.…”

Section: Introductionmentioning

confidence: 60%

“…However, our sample size compares to earlier samples in the ERP field, which used GTS patients samples at n=6 (Van de Wetering et al, 1985), n=10 (Johannes et al, 2001a(Johannes et al, ,b, 2003, n=12 (Johannes et al, 1997) and n=24 (van Woerkom et al, 1994). The same applies with ERP studies of OCD patients with various sample sizes from a n=8 (Di Russo et al, 2000), n=9 (Gehring et al, 2000), n=13 (Morault et al, 1997), n=15 (Sanz et al, 2001) and n=21 (Morault et al, 1998). Future research would ideally recruit larger samples and compare GTS+OCS with other comorbid groups such as highly anxious, depressive or hyperactive GTS patients.…”

Section: Possible Influences Of Confounding Variablesmentioning

confidence: 91%

“…We also hypothesize that the GTS group will demonstrate a normal P300 oddball effect. Following past studies showing smaller amplitude in OCD participants during an oddball task (Sanz et al, 2001), we hypothesize that the presence of OCS will attenuate the P300 amplitude. Consequently, we expect the OCD group to demonstrate a reduced P300 compared to the three other groups.…”

Section: Introductionmentioning

confidence: 91%

“…Nevertheless, these P300 patterns were elicited in slightly different experimental procedures, so nuancing homogeneous interpretation of their functional significance across groups. In GTS, working memory processes have been found to be affected in complex attentional performance while in OCD, anomalies appeared non specifically across a wide spectrum of cognitive demands (Kim et al, 2003;Mavrogiorgou et al, 2002;Miyata et al, 1998;Morault et al, 1998;Sanz et al, 2001;Towey et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

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Influence of comorbid obsessive-compulsive symptoms on brain event-related potentials in Gilles de la Tourette syndrome

Thibault

Felezeu

O’Connor

et al. 2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Approximately 30 to 50% of people suffering from Gilles de la Tourette Syndrome (GTS) also fulfill diagnostic criteria for obsessive-compulsive disorder (OCD). Despite this high degree of comorbidity, very few studies have addressed the question of obsessive-compulsive symptoms (OCS) in GTS patients using specific brain event-related potentials (ERP) responses. The aim of the current study was to quantify neurocognitive aspects of comorbidity, using ERPs. Fourteen adults with GTS (without OCD) were compared to a group of 12 participants with GTS and comorbid obsessive-compulsive symptoms (GTS+OCS), to a group of 15 participants with OCD and to a group of 14 control participants without neurological or psychiatric problems. The P200 and P300 components were recorded during a visual counting oddball task. Results showed intact P200 amplitude in all groups, whilst the P300 amplitude was affected differentially across groups. The P300 oddball effect was reduced in participants in both OCD and GTS+OCS groups in the anterior region. However, the P300 oddball effect was significantly larger in participants of the GTS group compared to all other groups, mostly in the parietal region. These findings suggest that adults with GTS are characterized by enhanced working memory updating processes and that the superimposition of OCS can lead to a reduction of these processes. The discrepancy between our findings and results obtained in previous studies on GTS could reflect the modulating effect of OCS on late ERP components.

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Section: Influence Of Obsessive-compulsive Symptoms On Erp Profilesupporting

confidence: 83%

Section: Introductionmentioning

confidence: 60%

Section: Possible Influences Of Confounding Variablesmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Influence of comorbid obsessive-compulsive symptoms on brain event-related potentials in Gilles de la Tourette syndrome

Thibault

Felezeu

O’Connor

et al. 2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Current Awareness

2001

Human Psychopharmacology

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Books, Reviews & Symposia; 2 General; 3 Psychotropic Drugs ‐ General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Neuropsychologie der Zwangsstörung

Leplow

2010

Neuropsychologie Psychischer Störungen

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Auditory P300 event related potential and serotonin reuptake inhibitor treatment in obsessive-compulsive disorder patients

Cited by 62 publications

References 30 publications

Influence of comorbid obsessive-compulsive symptoms on brain event-related potentials in Gilles de la Tourette syndrome

Influence of comorbid obsessive-compulsive symptoms on brain event-related potentials in Gilles de la Tourette syndrome

Current Awareness

Neuropsychologie der Zwangsstörung

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