Auditory Perception in Schizophrenia: A Second Study of the Intonation Test

Jonsson, Carl‐Otto; Sjöstedt, A.

doi:10.1111/j.1600-0447.1973.tb04450.x

Cited by 27 publications

(12 citation statements)

References 13 publications

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“…Deficits in tone matching in schizophrenia had been reported, in fact, in schizophrenia in the early 1970s by Jonsson & Sjostedt (1973), who used the pitch intonation test. However, these findings were rarely cited and did not penetrate into general conceptualizations of schizophrenia at the time.…”

Section: Bottom-up Contributions To Impaired Processing In Schizophreniamentioning

confidence: 98%

When Doors of Perception Close: Bottom-up Models of Disrupted Cognition in Schizophrenia

Javitt

2009

Annu. Rev. Clin. Psychol.

463

386

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Schizophrenia is a major mental disorder that affects approximately 1% of the population worldwide. Cognitive deficits are a key feature of schizophrenia and a primary cause of long-term disability. Current neurophysiological models of schizophrenia focus on distributed brain dysfunction with bottom-up as well as top-down components. Bottom-up deficits in cognitive processing are driven by impairments in basic perceptual processes that localize to primary sensory brain regions. Within the auditory system, deficits are apparent in elemental sensory processing, such as tone matching following brief delay. Such deficits lead to impairments in higher-order processes such as phonological processing and auditory emotion recognition. Within the visual system, deficits are apparent in functioning of the magnocellular visual pathway, leading to higher-order deficits in processes such as perceptual closure, object recognition, and reading. In both auditory and visual systems, patterns of deficit are consistent with underlying impairment of brain N-methyl-d-aspartate receptor systems.

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Section: Bottom-up Contributions To Impaired Processing In Schizophreniamentioning

confidence: 98%

When Doors of Perception Close: Bottom-up Models of Disrupted Cognition in Schizophrenia

Javitt

2009

Annu. Rev. Clin. Psychol.

463

386

View full text Add to dashboard Cite

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“…However some programs begin the hierarchy at an earlier level of information processing, first targeting early sensory information processing in the auditory, verbal, and visuospatial domains, followed by practice on exercises that incorporate working memory, verbal learning and memory. This approach is guided by data indicating prevalent and large effect size deficits in sensory perceptual information processing in schizophrenia when measured neurophysiologically and behaviorally (Gold et al, 2012; Javitt, 2009; Javitt, Shelley, & Ritter, 2000; Jonsson & Sjostedt, 1973; Rabinowicz, Silipo, Goldman, & Javitt, 2000). Deficits in early sensory information processing may affect the fidelity of information encoding, and the appropriate selection or filtering of task-relevant versus irrelevant stimuli which feed forward, rendering complex higher level functions (e.g.…”

Section: Cognitive Characteristics As a Tailoring Variablementioning

confidence: 99%

Personalised treatment for cognitive dysfunction in individuals with schizophrenia spectrum disorders

Medalia

Saperstein

Hansen

et al. 2016

Neuropsychological Rehabilitation

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Cognitive deficits are a well-recognized issue for individuals diagnosed with schizophrenia spectrum disorders. Despite positive group findings for the use of cognitive remediation (CR) interventions, there are substantial individual differences in response to treatment. In addition, the aggregate CR literature reports low moderate effect sizes for cognitive and functional outcomes. Based on personalized medicine theory, this paper uses extant CR literature to examine the individual characteristics determined to predict treatment response. These characteristics, which fall into the broad categories of cognitive, psychological, and biological can be used as tailoring variables to personalize CR to an individual’s unique profile. Personalization through the use of these tailoring variables has the potential to improve the delivery of CR to maximize treatment outcomes.

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“…Early auditory processing (EAP) deficits in SZ were first demonstrated in 1973 4 but were not studied systematically until ~20 years ago. Since then EAP deficits have been demonstrated behaviorally using paradigms such as simple tone-matching task (TMT) 5–7 , and neurophysiologically, using measures such as mismatch negativity (MMN) 8–10 .…”

Section: Introductionmentioning

confidence: 99%

Bimodal distribution of tone-matching deficits indicates discrete pathophysiological entities within the syndrome of schizophrenia

et al. 2019

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To date, no measures are available that permit differentiation of discrete, clinically distinct subtypes of schizophrenia (SZ) with potential differential underlying pathophysiologies. Over recent years, there has been increasing recognition that SZ is heterogeneously associated with deficits in early auditory processing (EAP), as demonstrated using clinically applicable tasks such as tone-matching task (TMT). Here, we pooled TMT performances across 310 SZ individuals and 219 healthy controls (HC), along with clinical, cognitive, and resting-state functional-connectivity MRI (rsFC-MRI) measures. In addition, TMT was measured in a group of 24 patients at symptomatic clinical high risk (CHR) for SZ and 24 age-matched HC (age range 7–27 years). We provide the first demonstration that the EAP deficits are bimodally distributed across SZ subjects ( P < 0.0001 vs. unimodal distribution), with one group showing entirely unimpaired TMT performance (SZ-EAP+), and a second showing an extremely large TMT impairment (SZ-EAP−), relative to both controls ( d = 2.1) and SZ-EAP+ patients ( d = 3.4). The SZ-EAP− group predominated among samples drawn from inpatient sites, showed higher levels of cognitive symptoms (PANSS), worse social cognition and a differential deficit in neurocognition (MATRICS battery), and reduced functional capacity. rsFC-MRI analyses showed significant reduction in SZ-EAP− relative to controls between subcortical and cortical auditory regions. As opposed to SZ, CHR patients showed intact EAP function. In HC age-matched to CHR, EAP ability was shown to increase across the age range of vulnerability preceding SZ onset. These results indicate that EAP measure segregates between discrete SZ subgroups. As TMT can be readily implemented within routine clinical settings, its use may be critical to account for the heterogeneity of clinical outcomes currently observed across SZ patients, as well as for pre-clinical detection and efficacious treatment selection.

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Auditory Perception in Schizophrenia: A Second Study of the Intonation Test

Cited by 27 publications

References 13 publications

When Doors of Perception Close: Bottom-up Models of Disrupted Cognition in Schizophrenia

When Doors of Perception Close: Bottom-up Models of Disrupted Cognition in Schizophrenia

Personalised treatment for cognitive dysfunction in individuals with schizophrenia spectrum disorders

Bimodal distribution of tone-matching deficits indicates discrete pathophysiological entities within the syndrome of schizophrenia

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