Auditory processing following infantile spasms: An event‐related potential study

Fosi, Tangunu; Werner, Klaus; Boyd, Stewart; Haan, Michelle de; Scott, Rod C.; Neville, Brian

doi:10.1111/epi.13725

Cited by 4 publications

(1 citation statement)

References 48 publications

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“…Though asymmetric-left greater than right-hypermetabolism has not been previously reported in FDG-PET studies, our finding may support prior speculation that left hemispheric excitatory synapses endure longer than their right hemisphere counterparts in infancy, and may thus be more vulnerable to epileptic activity [20,21]. Among patients with infantile spasms, structural imaging studies have demonstrated an asymmetric increase in left temporal grey matter volume [22], and functional studies using event-related potentials have identified impaired temporal maturation and network topology, which manifest as dysfunction of auditory processing [23,24]. The left greater than right hypermetabolism seen in our cohort may be a metabolic representation of these asymmetric structural and functional abnormalities.…”

Section: Discussionsupporting

confidence: 87%

Hypsarrhythmia is associated with widespread, asymmetric cerebral hypermetabolism

Weng

Ahn²,

Hussain

2019

Seizure

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Hypsarrhythmia is the interictal EEG pattern most often associated with infantile spasms. We set out to evaluate the metabolic impact of hypsarrhythmia among patients with infantile spasms by contrasting regional cerebral metabolic activity among children with and without hypsarrhythmia. Methods: Patients with video-EEG confirmed infantile spasms who underwent simultaneous interictal EEG and FDG-PET as part of a surgical evaluation were retrospectively identified. Pons-normalized relative cerebral metabolic activity (RCA) was ascertained in 18 cortical and 6 subcortical pre-specified regions of interest (ROIs). Results: We identified 63 patients with infantile spasms who underwent simultaneous EEG/PET, including children with hypsarrhythmia (n = 9), high-voltage EEG background (n = 20), and multifocal independent spike discharges (MISD) (n = 34). Among them, a putative epileptogenic zone was identified within the lefthemisphere only (n = 27), right-hemisphere only (n = 20), or assumed to be bilateral (n = 16). After adjustment for age at PET, the presence of hypsarrhythmia was associated with hypermetabolism in 11 of 18 cortical ROI's. After adjustment for lateralized epileptogenic zones, the association between hypsarrhythmia and hypermetabolism was generally stronger within the left hemisphere. Conclusion: Hypsarrhythmia is associated with widespread-and curiously left more than right-elevations in pons-normalized RCA, which is not evident on routine clinical review of individual PET studies. This study suggests that hypsarrhythmia may be a quasi-ictal phenomenon based on widespread and usually bilateral cortical hypermetabolism.

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Section: Discussionsupporting

confidence: 87%

Hypsarrhythmia is associated with widespread, asymmetric cerebral hypermetabolism

Weng

Ahn²,

Hussain

2019

Seizure

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A Potential Mechanism of Neurological Impairment in Children With Infantile Spasm: Based on Microanatomic Structure Analysis Employing Voxel-Based Morphometry and Surface-Based Morphometry

Wang,

Huang,

Chen

et al. 2024

Pediatric Neurology

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P300 development from infancy to adolescence

Riggins

Scott

2019

Psychophysiology

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This article provides an overview of P300 research from infancy through adolescence. First, a brief historical overview is provided highlighting seminal studies that began exploration of the P300 component in developmental groups. Overall, these studies suggest that the P300 can be detected in children and appears to reflect similar cognitive processes to those in adults; however, it is significantly delayed in its latency to peak. Second, two striking findings from developmental research are the lack of a clear P300 component in infancy and differential electrophysiological responses to novel, unexpected stimuli in children, adolescents, and adults. Third, contemporary questions are described, which include P300‐like components in infancy, alteration of P300 in atypically developing groups, relations between P300 and behavior, individual differences of P300, and neural substrates of P300 across development. Finally, we conclude with comments regarding the power of a developmental perspective and suggestions for important issues that should be addressed in the next 50 years of P300 research.

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Auditory processing following infantile spasms: An event‐related potential study

Abstract: Complex acoustic information is processed poorly following IS. This would impair language. Treatment did not reverse this phenomenon, but may have limited its severity. The data are most consistent with altered connectivity of the cortical acoustic processing areas induced by IS.

Cited by 4 publications

References 48 publications

Hypsarrhythmia is associated with widespread, asymmetric cerebral hypermetabolism

Hypsarrhythmia is associated with widespread, asymmetric cerebral hypermetabolism

A Potential Mechanism of Neurological Impairment in Children With Infantile Spasm: Based on Microanatomic Structure Analysis Employing Voxel-Based Morphometry and Surface-Based Morphometry

P300 development from infancy to adolescence

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