Auditory resting-state functional connectivity in tinnitus and modulation with transcranial direct current stimulation

Minami, Shujiro; Oishi, Naoki; Watabe, Toshihisa; Uno, Kimiichi; Kaga, Kimitaka; Ogawa, Kaoru

doi:10.3109/00016489.2015.1068952

Cited by 24 publications

(18 citation statements)

References 21 publications

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“…For example, fNIRS was recently used to demonstrate that profoundly-deafened humans have higher cross-modal plasticity in temporal lobe to visual stimuli than normal-hearing adults [59]. Moreover, trans-cranial direct current stimulation produces changes in RSFC of primary auditory cortex in tinnitus but not in control participants [60]. Finally, it should be noted that cross-modal plasticity may be dependent on the synchrony or timing of the stimuli presented.…”

Section: Discussionmentioning

confidence: 99%

Tinnitus alters resting state functional connectivity (RSFC) in human auditory and non-auditory brain regions as measured by functional near-infrared spectroscopy (fNIRS)

San-Juan

Issa

et al. 2017

PLoS ONE

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Tinnitus, or phantom sound perception, leads to increased spontaneous neural firing rates and enhanced synchrony in central auditory circuits in animal models. These putative physiologic correlates of tinnitus to date have not been well translated in the brain of the human tinnitus sufferer. Using functional near-infrared spectroscopy (fNIRS) we recently showed that tinnitus in humans leads to maintained hemodynamic activity in auditory and adjacent, non-auditory cortices. Here we used fNIRS technology to investigate changes in resting state functional connectivity between human auditory and non-auditory brain regions in normal-hearing, bilateral subjective tinnitus and controls before and after auditory stimulation. Hemodynamic activity was monitored over the region of interest (primary auditory cortex) and non-region of interest (adjacent non-auditory cortices) and functional brain connectivity was measured during a 60-second baseline/period of silence before and after a passive auditory challenge consisting of alternating pure tones (750 and 8000Hz), broadband noise and silence. Functional connectivity was measured between all channel-pairs. Prior to stimulation, connectivity of the region of interest to the temporal and fronto-temporal region was decreased in tinnitus participants compared to controls. Overall, connectivity in tinnitus was differentially altered as compared to controls following sound stimulation. Enhanced connectivity was seen in both auditory and non-auditory regions in the tinnitus brain, while controls showed a decrease in connectivity following sound stimulation. In tinnitus, the strength of connectivity was increased between auditory cortex and fronto-temporal, fronto-parietal, temporal, occipito-temporal and occipital cortices. Together these data suggest that central auditory and non-auditory brain regions are modified in tinnitus and that resting functional connectivity measured by fNIRS technology may contribute to conscious phantom sound perception and potentially serve as an objective measure of central neural pathology.

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Section: Discussionmentioning

confidence: 99%

Tinnitus alters resting state functional connectivity (RSFC) in human auditory and non-auditory brain regions as measured by functional near-infrared spectroscopy (fNIRS)

San-Juan

Issa

et al. 2017

PLoS ONE

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“…A growing number of studies have used resting-state fMRI to investigate tinnitus (Husain and Schmidt, 2014) and multiple brain networks implicated in tinnitus have been identified, such as the auditory network (Burton et al, 2012; Kim et al, 2012; Maudoux et al, 2012a,b; Schmidt et al, 2013; Hinkley et al, 2015; Minami et al, 2015; Leaver et al, 2016b), default mode network (DMN; Schmidt et al, 2013; Chen et al, 2014, 2015d; Leaver et al, 2016b), dorsal attention network (DAN; Burton et al, 2012; Schmidt et al, 2013), ventral attention network (VAN; Burton et al, 2012), and visual network (Burton et al, 2012; Chen et al, 2014, 2015d). As such, tinnitus can be seen as the interaction of multiple brain subnetworks, each contributing to different aspects of tinnitus such as its acoustic features, emotional affect and awareness or attention.…”

Section: Introductionmentioning

confidence: 99%

Resting-State Brain Abnormalities in Chronic Subjective Tinnitus: A Meta-Analysis

Chen

Wang

et al. 2017

Front. Hum. Neurosci.

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Purpose: The neural mechanisms that give rise to the phantom sound of tinnitus have not been fully elucidated. Neuroimaging studies have revealed abnormalities in resting-state activity that could represent the neural signature of tinnitus, but there is considerable heterogeneity in the data. To address this issue, we conducted a meta-analysis of published neuroimaging studies aimed at identifying a common core of resting-state brain abnormalities in tinnitus patients.Methods: A systematic search was conducted for whole-brain resting-state neuroimaging studies with SPECT, PET and functional MRI that compared chronic tinnitus patients with healthy controls. The authors searched PubMed, Science Direct, Web of Knowledge and Embase databases for neuroimaging studies on tinnitus published up to September 2016. From each study, coordinates were extracted from clusters with significant differences between tinnitus subjects and controls. Meta-analysis was performed using the activation likelihood estimation (ALE) method.Results: Data were included from nine resting-state neuroimaging studies that reported a total of 51 distinct foci. The meta-analysis identified consistent regions of increased resting-state brain activity in tinnitus patients relative to controls that included, bilaterally, the insula, middle temporal gyrus (MTG), inferior frontal gyrus (IFG), parahippocampal gyrus, cerebellum posterior lobe and right superior frontal gyrus. Moreover, decreased brain activity was only observed in the left cuneus and right thalamus.Conclusions: The current meta-analysis is, to our knowledge, the first to demonstrate a characteristic pattern of resting-state brain abnormalities that may serve as neuroimaging markers and contribute to the understanding of neuropathophysiological mechanisms for chronic tinnitus.

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“…The significance threshold was set at P < .05 (false discovery rate‐corrected). As auditory‐related regions, Heschl's gyrus, planum temporaleale, planum polare, operculum, insular cortex, and superior temporal gyrus were set as the ROI from our previous reports …”

Section: Methodsmentioning

confidence: 99%

“…Rs‐fMRI is used to study connectivity in the brain by acquiring fMRI data from a subject lying “at rest” in the scanner and is based upon the premise that spontaneous activity patterns in functionally related brain regions are temporally correlated . We previously reported that tinnitus patients with or without hearing loss showed reduced levels of statistically significant auditory related FC in comparison with normal hearing control subjects, and we succeeded in objective diagnosis of tinnitus with 86% sensitivity and 74% specificity by focusing only on auditory‐related FC . The prevalence of hearing loss and tinnitus is more common in the older population compared with the younger population .…”

Section: Introductionmentioning

confidence: 99%

Age‐related change of auditory functional connectivity in Human Connectome Project data and tinnitus patients

Minami

Oishi

Watabe

et al. 2020

Laryngoscope Investig Oto

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Background We reported that tinnitus patients showed reduced levels of auditory functional connectivity (FC) in comparison with normal hearing control subjects, and that we succeeded in objective diagnosis of tinnitus with 86% sensitivity and 74% specificity by focusing only on auditory‐related FC. However, the age‐related change of auditory FC is not clarified. In this study, we examine age‐related change of the auditory FC using the database of Human Connectome Project (HCP) and compared with our database of tinnitus patients. Method From the HCP database HCP Lifespan Pilot project, we studied five age groups, 8 to 9 years old, 14 to 15, 25 to 35, 45 to 55, and 65 to 75. We also applied our tinnitus patients' resting‐state functional magnetic resonance imaging (fMRI) database, which is divided into three generations; 20 to 40 years old, 40 to 60, and 60 to 80 to compare with the HCP database. The resting state fMRI analyses were performed using the CONN toolbox version 18. As auditory‐related regions, Heschl's gyrus, planum temporale, planum polare, operculum, insular cortex, and superior temporal gyrus were set as the regions of interest from our previous reports. Result Auditory FC is strongest among adolescents and reduces with age. But the auditory FC of tinnitus patients were significantly less than those of HCP data in each generation. Conclusion Although auditory FC decreases with age, tinnitus patients have less auditory FC compared with age‐matched controls. The age‐matched cutoff values are necessary for an objective diagnosis of tinnitus with resting state fMRI.

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Auditory resting-state functional connectivity in tinnitus and modulation with transcranial direct current stimulation

Cited by 24 publications

References 21 publications

Tinnitus alters resting state functional connectivity (RSFC) in human auditory and non-auditory brain regions as measured by functional near-infrared spectroscopy (fNIRS)

Tinnitus alters resting state functional connectivity (RSFC) in human auditory and non-auditory brain regions as measured by functional near-infrared spectroscopy (fNIRS)

Resting-State Brain Abnormalities in Chronic Subjective Tinnitus: A Meta-Analysis

Age‐related change of auditory functional connectivity in Human Connectome Project data and tinnitus patients

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