Auditory sensory gating in the rat hippocampus: modulation by brainstem activity

Bickford, Paula C.; Luntz-Leybman, Vera; Freedman, Robert

doi:10.1016/0006-8993(93)91486-c

Cited by 60 publications

(33 citation statements)

References 15 publications

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“…Consistent with this idea, some PPTg cells in cat were found to respond to conditioned stimuli in a context-dependent way, failing to respond to the same cue when another signal indicated a different task requirement (Dormont et al, 1998). However, these data are difficult to interpret, because there were multiple sequential sensory cues, which may have triggered prepulse inhibition of later responses (Bickford et al, 1993;Moxon et al, 1999).…”

Section: Discussionmentioning

confidence: 86%

Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Pan

Hyland²

2005

J. Neurosci.

184

170

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Midbrain dopamine (DA) neurons respond to sensory cues that predict reward. We tested the hypothesis that projections from the pedunculopontine tegmental nucleus (PPTg) are involved in driving this DA cell activity. First, the activity of PPTg and DA neurons was compared in a cued-reward associative learning paradigm. The majority of PPTg neurons showed phasic responses to the onset of sensory cues, at significantly shorter latency than DA cells, consistent with a PPTg-to-DA transmission of information. However, unlike DA cells, PPTg responses were almost entirely independent of whether signals were associated with rewards. Second, DA neuron responses to the cues were recorded in free-moving rats during reversible inactivation of the PPTg by microinfusion of local anesthetic. The results showed clear suppression of conditioned sensory responses of DA neurons after PPTg inactivation that was not seen after saline infusion or in non-DA cells. We propose that the PPTg relays information about the precise timing of attended sensory events, which is integrated with information about reward context by DA neurons.

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Section: Discussionmentioning

confidence: 86%

Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Pan

Hyland²

2005

J. Neurosci.

184

170

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Section: Compensatory Changesmentioning

confidence: 99%

“…Filtering of repetitive auditory stimulation has also been observed in the pontine reticular formation (PRF) (Bickford et al, 1993;Moxon et al, 1999), in the medial septum (Moxon et al, 1999), in the reticular thalamic nucleus (RTN) (Krause et al, 2003) and in the amygdala (Cromwell et al, 2005). In addition, hippocampal auditory gating is influenced by stimulation of both the PRF and nucleus of the lateral lemniscus (NLL) (Bickford et al, 1993). All but one of these brain regions, the PRF, appear to express the α7 nicotinic receptor (Arimatsu and Seto, 1982;Azam et al, 2003;Breese et al, 1997;Happe and Morley, 2004;Hellstrom-Lindahl et al, 1998;Henderson et al, 2005;Seguela et al, 1993;Thinschmidt et al, 2005;Whiteaker et al, 1999;Zhang et al, 1998).…”

Section: Compensatory Changesmentioning

confidence: 99%

Altered hippocampal circuit function in C3H α7 null mutant heterozygous mice

et al. 2008

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The α7 subtype of nicotinic receptor is highly expressed in the hippocampus where it is purported to modulate release of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). The α7 receptormediated release of GABA is thought to contribute to hippocampal inhibition (gating) of response to repetitive auditory stimulation. This hypothesis is supported by observations of hippocampal auditory gating deficits in mouse strains with low levels of hippocampal α7 receptors compared to strains with high levels of hippocampal α7 receptors. The difficulty with comparisons between mouse strains, however, is that different strains have different genetic backgrounds. Thus, the observed interstrain differences in hippocampal auditory gating might result from factors other than interstrain variations in the density of hippocampal α7 receptors. To address this issue, hippocampal binding of the α7 receptor-selective antagonist α-bungarotoxin as well as hippocampal auditory gating characteristics were compared in C3H wild type and C3H α7 receptor null mutant heterozygous mice. The C3H α7 heterozygous mice exhibited significant reductions in hippocampal α7 receptors levels and abnormal hippocampal auditory gating compared to the C3H wild type mice. In addition, a general increase in CA3 pyramidal neuron responsivity was observed in the heterozygous mice compared to the wild type mice. These data suggest that decreasing hippocampal α7 receptor density results in a profound alteration in hippocampal circuit function.

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“…In the hippocampus, both lemniscal and nonlemniscal auditory pathways converge, resulting in a gated response to auditory stimuli in the CA3 region (Adler et al 1998). A modulatory action on hippocampal activity by the brain stem has been demonstrated (Vertes and Kocsis 1997) and is thought to contribute to auditory gating in this brain region (Bickford et al 1993;Vertes and Kocsis 1997). But how do these auditory pathways relate to the nRT and how do they contribute to auditory gating in this thalamic region?…”

Section: Mechanisms Underlying Auditory Gating: Lemniscal Versus Nonlmentioning

confidence: 99%

Auditory sensory gating in hippocampus and reticular thalamic neurons in anesthetized rats

Krause¹,

Hoffmann²,

Hajós³

2003

Biological Psychiatry

119

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Auditory sensory gating in the rat hippocampus: modulation by brainstem activity

Cited by 60 publications

References 15 publications

Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Altered hippocampal circuit function in C3H α7 null mutant heterozygous mice

Auditory sensory gating in hippocampus and reticular thalamic neurons in anesthetized rats

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