Auditory steady state response in hearing assessment in infants with cytomegalovirus

Abstract

OBJECTIVE: To report an infant with congenital cytomegalovirus and progressive sensorineural hearing loss, who was assessed by three methods of hearing evaluation. CASE DESCRIPTION: In the first audiometry, at four months of age, the infant showed abnormal response in Otoacoustic Emissions and normal Auditory Brainstem Response (ABR), with electrophysiological threshold in 30dBnHL, in both ears. With six months of age, he showed bilateral absence of the ABR at 100dBnHL. The behavioral observational audiometry was impaired due to the delay in neuropsychomotor development. At eight months of age, he was submitted to Auditory Steady State Response (ASSR) and the thresholds were 50, 70, absent in 110 and in 100dB, respectively for 500, 1,000, 2,000 and 4,000Hz in the right ear, and 70, 90, 90 and absent in 100dB, respectively for 500, 1,000, 2,000 and 4,000Hz in the left ear. COMMENTS: In the first evaluation, the infant had abnormal Otoacoustic Emission and normal ABR, which became altered at six months of age. The hearing loss severity could be identified only by the ASSR, which allowed the best procedure for hearing aids adaptation. The case description highlights the importance of the hearing status follow-up for children with congenital cytomegalovirus.

Improved Transient Response Estimations in Predicting 40 Hz Auditory Steady-State Response Using Deconvolution Methods

“…The auditory steady-state response (ASSR) elicited by periodical auditory stimulation is a major approach in clinic for hearing screening and frequency-specific hearing assessment (e.g., Silva et al, 2013 ; Francois et al, 2016 ). Recently, increasing number of studies have found abnormalities of ASSR in psychiatric disorders such as schizophrenia (O'Donnell et al, 2013 ; Thune et al, 2016 ), autism (Gandal et al, 2010 ), and bipolar disorder (Rass et al, 2010 ; Oda et al, 2012 ; Isomura et al, 2016 ).…”

Newborn hearing screening program in China: a narrative review of the issues in screening and management

“…Studies have shown that 10% of children with cCMV present with obvious clinical symptoms at birth and 90% are born without specific clinical signs or symptoms. Approximately 30%–60% of children with symptomatic infection and 10%–15% of children with asymptomatic infection develop SNHL, so the early detection of such infections in children is particularly important ( 101 ). The diagnostic rate of bilateral profound SNHL using a combined genetic deafness test and CMV DNA detection test was reported to be 46.4% ( 102 ).…”