Auditory Steady State Responses in Normal-Hearing and Hearing-Impaired Adults

Wilding, Timothy; McKay, Colette M.; Baker, Richard J.; Kluk, Karolina

doi:10.1097/aud.0b013e318230bba0

Cited by 23 publications

(21 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the anatomical dissociations in the effects of SNHL on cortical envelope coding metrics identified in the present study suggest some influence of SNHL on central auditory processing. Specifically, the functional asymmetry in the right-lateralized enhanced envelope coding shown here presumably occurs at the cortical level ( Poeppel, 2003 ; Luo and Poeppel, 2007 ), adding to the increasing evidence that auditory pathology results in changes in the central auditory system ( Morita et al, 2003 ; Wienbruch et al, 2006 ; Wilding et al, 2012 ; Alain et al, 2014 ; Auerbach et al, 2014 ).…”

Section: Discussionmentioning

confidence: 58%

“…The present study establishes a link between the amplitude of the cortical phase-locked response to modulated sounds (envelope coding) and speech identification in the presence of modulated background noise. Both the amplitude ( Wilding et al, 2012 ) and the fidelity ( Presacco et al, 2016 ) of cortical envelope coding were enhanced in listeners with sensorineural hearing loss (SNHL). Our results show that SNHL exerts differential effects on envelope coding in left and right auditory cortices and posteromedial and posterolateral auditory cortices.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Magnified Neural Envelope Coding Predicts Deficits in Speech Perception in Noise

et al. 2017

View full text Add to dashboard Cite

Verbal communication in noisy backgrounds is challenging. Understanding speech in background noise that fluctuates in intensity over time is particularly difficult for hearing-impaired listeners with a sensorineural hearing loss (SNHL). The reduction in fast-acting cochlear compression associated with SNHL exaggerates the perceived fluctuations in intensity in amplitude-modulated sounds. SNHL-induced changes in the coding of amplitude-modulated sounds may have a detrimental effect on the ability of SNHL listeners to understand speech in the presence of modulated background noise. To date, direct evidence for a link between magnified envelope coding and deficits in speech identification in modulated noise has been absent. Here, magnetoencephalography was used to quantify the effects of SNHL on phase locking to the temporal envelope of modulated noise (envelope coding) in human auditory cortex. Our results show that SNHL enhances the amplitude of envelope coding in posteromedial auditory cortex, whereas it enhances the fidelity of envelope coding in posteromedial and posterolateral auditory cortex. This dissociation was more evident in the right hemisphere, demonstrating functional lateralization in enhanced envelope coding in SNHL listeners. However, enhanced envelope coding was not perceptually beneficial. Our results also show that both hearing thresholds and, to a lesser extent, magnified cortical envelope coding in left posteromedial auditory cortex predict speech identification in modulated background noise. We propose a framework in which magnified envelope coding in posteromedial auditory cortex disrupts the segregation of speech from background noise, leading to deficits in speech perception in modulated background noise.SIGNIFICANCE STATEMENT People with hearing loss struggle to follow conversations in noisy environments. Background noise that fluctuates in intensity over time poses a particular challenge. Using magnetoencephalography, we demonstrate anatomically distinct cortical representations of modulated noise in normal-hearing and hearing-impaired listeners. This work provides the first link among hearing thresholds, the amplitude of cortical representations of modulated sounds, and the ability to understand speech in modulated background noise. In light of previous work, we propose that magnified cortical representations of modulated sounds disrupt the separation of speech from modulated background noise in auditory cortex.

show abstract

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Magnified Neural Envelope Coding Predicts Deficits in Speech Perception in Noise

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The difference of the high-response region might be derived from shape and/or volume differences of the brain between rats and human because volume conduction effects enable ECoG recording 17 . Indeed, threshold differences in bone-conduction ASSR between post-term infants and adults has been suggested to be due to skull maturation 8,30 . By using the switchable pedestal, we revealed the detectable signal from rat ASSR in temporal cortex, and difference of ASSR between rats and human.…”

Section: Discussionmentioning

confidence: 99%

Auditory Steady State Response; nature and utility as a translational science tool

Kozono

Honda

Tada

et al. 2019

Sci Rep

View full text Add to dashboard Cite

The auditory steady-state response (ASSR) has been used to detect auditory processing deficits in patients with psychiatric disorders. However, the methodology of ASSR recording from the brain surface has not been standardized in preclinical studies, limiting its use as a translational biomarker. The sites of maximal ASSR in humans are the vertex and/or middle frontal area, although it has been suggested that the auditory cortex is the source of the ASSR. We constructed and validated novel methods for ASSR recording using a switchable pedestal which allows ASSR recording alternatively from temporal or parietal cortex with a wide range of frequencies in freely moving rats. We further evaluated ASSR as a translational tool by assessing the effect of ketamine. The ASSR measured at parietal cortex did not show clear event-related spectral perturbation (ERSP) or inter-trial coherence (ITC) in any frequency bands or a change with ketamine. In contrast, the ASSR at temporal cortex showed clear ERSP and ITC where 40 Hz was maximal in both gamma-band frequencies. Ketamine exerted a biphasic effect in ERSP at gamma bands. These findings suggest that temporal cortex recording with a wide frequency range is a robust methodology to detect ASSR, potentially enabling application as a translational biomarker in psychiatric and developmental disorders.

show abstract

“…The adaptation of ASSR might have implications in the clinical practice, especially when recording protocols are based on averaging a reduced number of sequentially acquired epochs [6, 28, 29]. In such a practical situation, the ASSR computed after the completion of the averaging might be strongly influenced by the adaptation of the response.…”

Section: Introductionmentioning

confidence: 99%

“…Both weighted and sorted averaging have been applied to the analysis of ASSR. Weighted averaging is already available in commercial ASSR systems, and it is commonly used for research purposes [6, 25, 38]. Sorted averaging has only been tested experimentally [39], probably due to the relatively high computational cost of storing and sorting a large number of epochs during the online estimation of ASSRs.…”

Section: Introductionmentioning

confidence: 99%

Estimation of auditory steady-state responses based on the averaging of independent EEG epochs

et al. 2019

View full text Add to dashboard Cite

The amplitude of auditory steady-state responses (ASSRs) generated in the brainstem of rats exponentially decreases over the sequential averaging of EEG epochs. This behavior is partially due to the adaptation of the ASSR induced by the continuous and monotonous stimulation. In this study, we analyzed the potential clinical relevance of the ASSR adaptation. ASSR were elicited in eight anesthetized adult rats by 8-kHz tones, modulated in amplitude at 115 Hz. We called independent epochs to those EEG epochs acquired with sufficiently long inter-stimulus interval, so the ASSR contained in any given epoch is not affected by the previous stimulation. We tested whether the detection of ASSRs is improved when the response is computed by averaging independent EEG epochs, containing only unadapted auditory responses. The improvements in the ASSR detection obtained with standard, weighted and sorted averaging were compared. In the absence of artifacts, when the ASSR was elicited by continuous acoustic stimulation, the computation of the ASSR amplitude relied upon the averaging method. While the adaptive behavior of the ASSR was still evident after the weighting of epochs, the sorted averaging resulted in under-estimations of the ASSR amplitude. In the absence of artifacts, the ASSR amplitudes computed by averaging independent epochs did not depend on the averaging procedure. Averaging independent epochs resulted in higher ASSR amplitudes and halved the number of EEG epochs needed to be acquired to achieve the maximum detection rate of the ASSR. Acquisition protocols based on averaging independent EEG epochs, in combination with appropriate averaging methods for artifact reduction might contribute to develop more accurate hearing assessments based on ASSRs.

show abstract

Auditory Steady State Responses in Normal-Hearing and Hearing-Impaired Adults

Cited by 23 publications

References 20 publications

Magnified Neural Envelope Coding Predicts Deficits in Speech Perception in Noise

Magnified Neural Envelope Coding Predicts Deficits in Speech Perception in Noise

Auditory Steady State Response; nature and utility as a translational science tool

Estimation of auditory steady-state responses based on the averaging of independent EEG epochs

Contact Info

Product

Resources

About