Auditory stimulus discrimination recorded in dogs, as indicated by mismatch negativity (MMN)

Howell, Tiffani J.; Conduit, Russell; Toukhsati, Samia Rachael; Bennett, Pauleen

doi:10.1016/j.beproc.2011.09.009

Cited by 30 publications

(25 citation statements)

References 40 publications

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“…Previously researchers have made the case that physiological measures of canine cognition are required to complement behavioral studies, and have used non-invasive electroencephalography (EEG) to measure neural responses to auditory stimulus discrimination [71] and visual stimuli (specifically dog and human faces) [72], [73]. This work follows in their footsteps by incorporating fMRI as a non-invasive measure of brain function.…”

Section: Discussionmentioning

confidence: 99%

Functional MRI of the Olfactory System in Conscious Dogs

et al. 2014

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We depend upon the olfactory abilities of dogs for critical tasks such as detecting bombs, landmines, other hazardous chemicals and illicit substances. Hence, a mechanistic understanding of the olfactory system in dogs is of great scientific interest. Previous studies explored this aspect at the cellular and behavior levels; however, the cognitive-level neural substrates linking them have never been explored. This is critical given the fact that behavior is driven by filtered sensory representations in higher order cognitive areas rather than the raw odor maps of the olfactory bulb. Since sedated dogs cannot sniff, we investigated this using functional magnetic resonance imaging of conscious dogs. We addressed the technical challenges of head motion using a two pronged strategy of behavioral training to keep dogs' head as still as possible and a single camera optical head motion tracking system to account for residual jerky movements. We built a custom computer-controlled odorant delivery system which was synchronized with image acquisition, allowing the investigation of brain regions activated by odors. The olfactory bulb and piriform lobes were commonly activated in both awake and anesthetized dogs, while the frontal cortex was activated mainly in conscious dogs. Comparison of responses to low and high odor intensity showed differences in either the strength or spatial extent of activation in the olfactory bulb, piriform lobes, cerebellum, and frontal cortex. Our results demonstrate the viability of the proposed method for functional imaging of the olfactory system in conscious dogs. This could potentially open up a new field of research in detector dog technology.

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Section: Discussionmentioning

confidence: 99%

Functional MRI of the Olfactory System in Conscious Dogs

et al. 2014

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“…Here, however, we will focus on translation to rodent (rat and mouse) models, even though analogues of MMN have also been investigated in monkeys (Fishman and Steinschneider, 2012;Javitt et al, 1996), dogs (Howell et al, 2012)and birds (Schall et al, 2015). Rats and mice are the predominant speciesfor modelling schizophrenia because they can be bred in large numbers relatively quickly and pharmacological and highly selective neurobiological manipulations (e.g.…”

Section: The Need For Animal Modelsmentioning

confidence: 98%

Criteria for determining whether mismatch responses exist in animal models: Focus on rodents

Harms

Michie

Näätänen

2016

Biological Psychology

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“…However research on dog behavior has so far focused almost exclusively on awake functioning. Recent advances in the field have attempted to complement behavioral data with recording dog electroencephalogram in order to study awake brain activity, but these techniques were either minimally invasive (used needle electrodes : Howell et al 2011: Howell et al , 2012 or required extensive prior training (1.5 years: Kujala et al 2013;Törnqvist et al 2013). …”

Section: Introductionmentioning

confidence: 99%

Development of a non-invasive polysomnography technique for dogs (Canis familiaris)

Kis¹,

Szakadát²,

Kovács³

et al. 2014

Physiology & Behavior

161

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Recently dogs (Canis familiaris) have been demonstrated to be a promising model species for studying human behavior as they have adapted to the human niche and developed human-like socio-cognitive skills. Research on dog behavior, however, has so far almost exclusively focused on awake functioning.Here we present a self-developed non-invasive easily replicable canine polysomnography method. N=22 adult pet dogs (with their owners present) and N=12 adult humans participated in Study I. From these subjects N=7 dogs returned on two more occasions for Study II.In Study I. we give a descriptive analysis of the sleep electroencephalogram of the dog and compare it to human data. In order to validate our canine polysomnography method in Study II. we compare the sleep macrostructure and the EEG spectrum of dogs after a behaviorally active versus passive day.In Study I. we found that dogsʼ sleep EEG resembled that of human subjects and was generally in accordance with previous literature using invasive technology. In Study II. we show that similarly to previous results on humans daytime load of novel experiences affects the macrostructural and spectral aspects of subsequent sleep.Our results validate the family dog as a model species for studying the effects of pre-sleep activities on the EEG pattern under natural conditions and thus broaden the perspectives of the rapidly growing fields of canine cognition and sleep research.

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Auditory stimulus discrimination recorded in dogs, as indicated by mismatch negativity (MMN)

Cited by 30 publications

References 40 publications

Functional MRI of the Olfactory System in Conscious Dogs

Functional MRI of the Olfactory System in Conscious Dogs

Criteria for determining whether mismatch responses exist in animal models: Focus on rodents

Development of a non-invasive polysomnography technique for dogs (Canis familiaris)

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