Auditory system dysfunction in patients with vitiligo: is it a part of a systemic autoimmune process?

Mohamed, Enass Sayed; Said, Eman Abdel-Fattah; Sayed, Doaa S.; Awad, Sara M.; Ahmed, Mahrous

doi:10.4103/ejo.ejo_6_17

Cited by 11 publications

(8 citation statements)

References 28 publications

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“…Vitiligo is an acquired skin disorder characterized by a progressive loss in skin pigmentation due to the loss of melanocytes, the pigment producing cells in the skin. Among other tissues, melanocytes are present in the inner ear, eye and mucosal membranes [1][2][3] and, are therefore, also affected due to vitiligo [4]. Vitiligo affects around 0.5% of the global population and, although all ethnic groups are similarly affected, it is more noticeable and more severe in darkskinned individuals [5,6].…”

Section: Introductionmentioning

confidence: 99%

The relationship between stress and vitiligo: Evaluating perceived stress and electronic medical record data

et al. 2020

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Vitiligo is a T-cell mediated skin disorder characterized by progressive loss of skin color. In individuals genetically predisposed to the disease, various triggers contribute to the initiation of vitiligo. Precipitating factors can stress the skin, leading to T-cell activation and recruitment. Though hereditary factors are implicated in the pathogenesis of vitiligo, it is unknown whether precipitating, stressful events play a role in vitiligo. To understand this, we utilized a validated perceived stress scale (PSS) to measure this parameter in vitiligo patients compared to persons without vitiligo. Additionally, we probed a clinical database, using a knowledge linking software called ROCKET, to gauge stress-related conditions in the vitiligo patient population. From a pool of patients in an existing database, a hundred individuals with vitiligo and twenty-five age-and sex-matched comparison group of individuals without vitiligo completed an online survey to quantify their levels of perceived stress. In parallel, patients described specifics of their disease condition, including the affected body sites, the extent, duration and activity of their vitiligo. Perceived stress was significantly higher among vitiligo individuals compared to those without vitiligo. ROCKET analyses suggested signs of metabolic-related disease (i.e., 'stress') preceding vitiligo development. No correlation was found between perceived stress and the stage or the extent of disease, suggesting that elevated stress may not be a consequence of pigment loss alone. The data provide further support for stress as a precipitating factor in vitiligo development.

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Section: Introductionmentioning

confidence: 99%

The relationship between stress and vitiligo: Evaluating perceived stress and electronic medical record data

et al. 2020

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“…Sensorineural hearing loss has been reported in 4 to 37% of patients with vitiligo. [3][4][5][6][7][8][9] In the present study, 10 patients (19.2%) had SNHL. These patients were asymptomatic but, on audiological evaluation, were diagnosed with hearing loss.…”

Section: Discussionmentioning

confidence: 76%

“…Similar to other studies, we could not find any significant association between SNHL and duration of vitiligo. 4,9,20 According to Mahdi et al, 20 this could be explained by the possibility that otic melanocytes are affected at the start of vitiligo and then stabilize afterwards. However, in contrast to this, Aslan et al 8 and Ardic et al 16 found a statistically significant association between the duration of vitiligo and hearing loss.…”

Section: Discussionmentioning

confidence: 99%

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Audiological Abnormalities in Vitiligo Patients: A Hospital-Based Cross-Sectional Study

Prabha

Arora

Chhabra

et al. 2019

Int Arch Otorhinolaryngol

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Introduction There are some discrepancies in the literature about the influence of vitiligo on auditory functions. According to some authors, vitiligo influences hearing, whereas others question such influence. Therefore, we conducted a study to evaluate audiological functions in vitiligo patients. Objectives To determine the effect of vitiligo on auditory functions. Methods A hospital-based observational study was done from January 2017 to July 2017. Clinically diagnosed cases of vitiligo were enrolled for the study. A complete otological examination was conducted in all patients. Results Fifty-two patients (male: female 28:24) were included in the study. Ten patients (19.2%) had sensorineural hearing loss (SNHL). Seven patients (13.5%) had bilateral and 3 (5.7%) had unilateral SNHL. High frequency loss was seen in 17 out of 20 ears (10 affected patients), 6 ears had both low and high-frequency hearing loss. Of 12 ears with speech frequency involvement, mild hearing loss was seen in 5 and moderate to severe in 1 ear. Most cases of SNHL were detected in the age group 41 to 60 years old (63.6%), which was statistically significant (p-value 0.00). Conclusion The results of this study suggest that vitiligo patients require routine monitoring for auditory functions for early identification of SNHL. Older subjects with vitiligo might be at a higher risk for audiological abnormalities. These patients should also be informed regarding the associated risk with noise and ototoxic drug exposure.

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“…29 For example, a hearing threshold of > 0 dB was defined as hearing loss in one study included in the previous systematic review, 30 while a hearing threshold of > 25-30 dB was defined as hearing loss in other included studies. 7,21,[31][32][33] In our meta-analysis, the PTTs at various frequencies were compared to investigate which frequencies of hearing impairment was more commonly seen in vitiligo patients than controls. As shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

Association of vitiligo with high‐frequency sensorineural hearing loss: a systematic review and meta‐analysis

Lien

Ger

Chi

2021

Acad Dermatol Venereol

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The association between vitiligo and hearing loss has been noted but the specific frequencies and degrees of hearing impairment remain unclear. The objective of this systematic review was to investigate the relationship between vitiligo and hearing thresholds at various specific frequencies. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched MEDLINE and Embase for relevant studies from inception to 10th April 2021. Case-control studies, cross-sectional, or cohort studies that compared the frequency-specific hearing thresholds between vitiligo patients and age-matched non-vitiligo controls were included. There were neither language nor geographic limitations. We used the Newcastle-Ottawa Scale to assess the risk of bias of included studies.The DerSimonian and Laird random-effects model was utilized in meta-analyses due to expected clinical heterogeneity.We included 9 case-control studies with 371 vitiligo patients and 349 controls, which were rated with low or unclear risk.We found neither relevant cross-sectional nor cohort studies. The meta-analysis showed that when compared with controls, vitiligo patients had significantly higher pure-tone hearing thresholds at 2000, 4000, and 8000 Hz. In conclusions, vitiligo patients are prone to high-frequency sensorineural hearing loss.

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Auditory system dysfunction in patients with vitiligo: is it a part of a systemic autoimmune process?

Cited by 11 publications

References 28 publications

The relationship between stress and vitiligo: Evaluating perceived stress and electronic medical record data

The relationship between stress and vitiligo: Evaluating perceived stress and electronic medical record data

Audiological Abnormalities in Vitiligo Patients: A Hospital-Based Cross-Sectional Study

Association of vitiligo with high‐frequency sensorineural hearing loss: a systematic review and meta‐analysis

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