Auditory Thalamocortical Transformations

Imaizumi, Kazuo

doi:10.1007/978-1-4614-6675-8_102

Cited by 2 publications

(3 citation statements)

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“…Its projections target the cerebral cortex primarily, but also extend to subcortical sites, such as the amygdala (LeDoux et al, 1991 ; Bordi and LeDoux, 1994 ) and TRN (Crabtree, 1998 ; Lee and Imaizumi, 2013 ). Classically, the MGB can be divided into three main divisions based on cytoarchitectural, connectional, and physiological criteria (Calford and Aitkin, 1983 ; Calford, 1983 ; Imig and Morel, 1985 ; Clerci and Coleman, 1990 ; Hashikawa et al, 1991 ; Smith et al, 2012 ; Imaizumi and Lee, 2015 ): the ventral (MGBv), dorsal (MGBd), and medial (MGBm) divisions (Winer, 1984 ; Rouiller et al, 1989 ); although, further subdivisions are proposed in some species, particularly within the dorsal division (Jones, 2007 ; Lee and Winer, 2011b ).…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, the dorsal division nuclei are non-tonotopically organized and are connectionally affiliated with corresponding non-tonotopically organized regions of the midbrain (dorsal division of the IC; ICd) and auditory cortex (e.g., secondary auditory cortex (AII); Huang and Winer, 2000 ; Smith et al, 2012 ). Finally, and perhaps most enigmatic, the medial division of the MGB receives polymodal inputs from the IC and projects broadly across many tonotopic, non-tonotopic, multimodal and limbic cortical areas (Lee and Winer, 2008a ; Imaizumi and Lee, 2015 ), terminating notably in cortical layers 1 and 6 (Huang and Winer, 2000 ) and also in the amygdala (LeDoux et al, 1991 ).…”

Section: Introductionmentioning

confidence: 99%

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Exploring functions for the non-lemniscal auditory thalamus

Lee

2015

Front. Neural Circuits

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The functions of the medial geniculate body (MGB) in normal hearing still remain somewhat enigmatic, in part due to the relatively unexplored properties of the non-lemniscal MGB nuclei. Indeed, the canonical view of the thalamus as a simple relay for transmitting ascending information to the cortex belies a role in higher-order forebrain processes. However, recent anatomical and physiological findings now suggest important information and affective processing roles for the non-primary auditory thalamic nuclei. The non-lemniscal nuclei send and receive feedforward and feedback projections among a wide constellation of midbrain, cortical, and limbic-related sites, which support potential conduits for auditory information flow to higher auditory cortical areas, mediators for transitioning among arousal states, and synchronizers of activity across expansive cortical territories. Considered here is a perspective on the putative and unresolved functional roles of the non-lemniscal nuclei of the MGB.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring functions for the non-lemniscal auditory thalamus

Lee

2015

Front. Neural Circuits

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“…The ACx possess a heterogeneous cytoarchitecture, connectivity and spiking activity, and it keeps the classical cortical layered architecture. Cortical neurons from the layers I recorded (~II/III to IV) receive thalamic inputs and inputs from other cortical cells (Imaizumi and Lee, 2015). The importance of cortical demyelination has been highlighted in MS patients, as an added culprit of the neurological manifestations of this disease (Kutzelnigg et al, 2005).…”

Section: Cortical-specific Myelin Loss Impairs Response Amplitudesmentioning

confidence: 99%

The role of oligodendrocytes in higher-order circuit functions

Corona¹,

Yared²

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The historical conception of glial cells as the 'glue' that holds the brain together has dramatically changed in the last years. The glia plays an active role in several mechanisms related to information processing in the brain and thus can change and shape circuits during development, adulthood and in an experience-dependent manner. Due to the recently described novel characteristics and roles that these cells have in brain function, we currently face ourselves with the necessity of widening the 'neuro' in neurosciences and give them the appropriate place they deserve.Focusing on oligodendroglia, the better-known function of these cells is to wrap axons in the central nervous system to facilitate propagation of action potentials along axons. There is also evidence for a role in metabolic support of the axons they wrap that is partially independent of myelination per se. Furthermore, nowadays we know this wrapping process is extraordinarily complex and prone to plastic modifications for the adaptation of information transmission, and vulnerable to injury. The study of sensory and cognitive abnormalities in patients with myelin lesions has provided evidence to understand the function of myelin in information processing. Nevertheless, due to the substantial heterogeneity of these myelin lesions within the study populations, the correlation of specific dysfunctions with an observed phenotype results in a difficult task. Additionally, the complexity of the contact, communication, and maintenance between axons and oligodendrocytes makes it difficult to dissect the partially independent roles that these cells have in information processing.Studies for the dynamic in vivo assessment of combined neuronal and oligodendrocyte functions are very scarce in the field and have only very recently begun to emerge. In this study, I assessed axonal auditory cortical function in mutant mice with either dysmyelination phenotypes or reduced metabolic axo-glial support to the axons. I found that dysmyelination generated deficits in temporal sound processing known to be essential for speech understanding. The perceptual deficits correlated with defects seen in the spiking activity of cortical cells. Together, they could not be explained by a loss in conduction velocity alone, suggesting that mechanisms that are secondary to the loss of myelin per se, are accounting for the diverse effects observed. Indeed, mice with oligodendrocyte-specific deficits in metabolic processes but relatively minor deficits in myelination showed similar impairments to those found with dysmyelination. A parallel study of the role of myelin in task-

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Auditory Thalamocortical Transformations

Cited by 2 publications

References 124 publications

Exploring functions for the non-lemniscal auditory thalamus

Exploring functions for the non-lemniscal auditory thalamus

The role of oligodendrocytes in higher-order circuit functions

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