Augmentation in anterior cruciate ligament reconstruction—a histological and biomechanical study on goats

Buma, P.; Kok, H. J.; Blankevoort, Leendert; Kuijpers, W.; Huiskes, R.; Kampen, A. van

doi:10.1007/s00264-003-0515-0

Cited by 31 publications

(19 citation statements)

References 19 publications

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“…To circumvent this limitation, a matrix composed of twisted silk fibers has recently been developed as a tissue engineered structure [80][81][82][83][84]. This structure mimics the arrangement of collagen fibers in the ligament and tendon, which has collagen fibers arranged to form fascicles, the fascicles then combine to form the ligament.…”

Section: Methodsmentioning

confidence: 99%

Bioactive scaffolds for bone and ligament tissue

Guarino¹,

Causa²,

Ambrosio³

2007

Expert Review of Medical Devices

211

149

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Bone and ligament injuries present the greatest challenges in connective tissue regeneration. The design of materials for these applications lies at the forefront of material science and is the epitome of its current ambition. Indeed, its goal is to design and fabricate reproducible, bioactive and bioresorbable 3D scaffolds with tailored properties that are able to maintain their structure and integrity for predictable times, even under load-bearing conditions. Unfortunately, the mechanical properties of today's available porous scaffolds fall short of those exhibited by complex human tissues, such as bone and ligament. The manipulation of structural parameters in the design of scaffolds and their bioactivation, through the incorporation of soluble and insoluble signals capable of promoting cell activities, are discussed as possible strategies to improve the formation of new tissues both in vitro and in vivo. This review focuses on the different approaches adopted to develop bioactive composite systems for use as temporary scaffolds for bone and anterior ligament regeneration.

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Section: Methodsmentioning

confidence: 99%

Bioactive scaffolds for bone and ligament tissue

Guarino¹,

Causa²,

Ambrosio³

2007

Expert Review of Medical Devices

211

149

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“…Rapid degradation and loss of mechanical Strength, biologically inert. Acidic degradation By product PDS [95] Common FDA-approved suture material Easily manufactured into diferent forms.…”

Section: Synthetic Polymersmentioning

confidence: 99%

“…Guidoin et al published that ABC surgicraft prostheses were well encapsulated by collagenous tissue which penetrated to the core of the ligament but after surgery it appears to be Anterior Cruciate Ligament Reconstruction associated with high failure rate. The graft was implanted by two diferent techniques and studies have shown that there is no signiicant diference between two graft replacements [95,109] . synovitis and stifness problem was noticed due to particulate debris [96,97,110,111] .…”

Section: Abc Surgicraftmentioning

confidence: 99%

A Systematic Review for Anterior Cruciate Ligament Reconstruction

Haque¹,

Wahed²,

Boughton³

et al. 2016

JAS

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Anterior cruciate ligament rupture is more common nowadays and it can lead to cartilage degeneration and osteoarthritis [1]. Anterior cruciate ligament reconstruction is frequent [2] and one of the challenging work in tissue engineering [3]. Anterior cruciate ligament is important for maintenance of knee movement [4]. ACL do not heal itself because of its intrinsically poor healing potential and surgical mediation is usually required [5,6]. Allograft and autograft were used for ACL reconstruction [7,8]. Due to several drawbacks of allograft and autograft synthetic grafts are the main option for ACL reconstruction [9]. Ligaments are made of bands of strong collagenous connective tissue. These paralleled collagen bundles attached to each other by crosslinking [10]. Mesenchymal cells produce this type of tissue; it can diferentiate into ibroblast cells. These ibroblast cells again diferentiate into ibrocytes cells. After maturation of ibrocytes they become inactive and produce ligaments. Ligaments attach two bones together at a joint, prevent dislocations of the joints, and restrain the movements of the joints. Ligaments contain two-thirds water and one-third solid. Collagen is the solid component of the ligament basically collagen types I and rests of the types are III, VI, XI and XIV. To maintain a considerable range of mechanical and biological properties of soft tissues, related organ systems, and bone collagen plays a vital role [11]. Structure of ACL ACL is not isometric [12]. ACL is made of collagen bundles which are paralleled and cross linked to each other. These bundles vary the tension among the ibers of the ligament [13]. Fibroblasts are joined to the bundles individually. It can produce new

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“…Sung and colleagues demonstrated fibroblast attachment and proliferation on scaffolds composed of braided polyglycolic acid (PGA) sutures coated with polycaprolactone (PCL) . Later, a braided polydioxanone (PDS) construct was evaluated in a caprine model but was found to be unsuitable because of the rapid loss of mechanical properties . Lu et al compared braided scaffolds composed of poly l ‐lactic acid (PLLA), PGA, and polylactic‐ co ‐glycolic acid (PLGA).…”

Section: Biomaterials Scaffoldsmentioning

confidence: 99%

“…41 Later, a braided polydioxanone (PDS) construct was evaluated in a caprine model but was found to be unsuitable because of the rapid loss of mechanical properties. 40 Lu et al compared braided scaffolds composed of poly L-lactic acid (PLLA), PGA, and polylactic-co-glycolic acid (PLGA). They concluded that PLLA scaffolds supported the highest rates of ACL fibroblast proliferation and had the most favorable mechanical properties for an ACL substitute.…”

Section: Pcl 43mentioning

confidence: 99%

Current tissue engineering strategies in anterior cruciate ligament reconstruction

Leong

Petrigliano

McAllister

2013

J Biomedical Materials Res

121

108

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Rupture of the anterior cruciate ligament (ACL) is one of the most common ligamentous injuries of the knee. Limitations of allografts and autografts in ACL reconstruction as well as recent advancements in biology and materials science have spurred interest in developing tissue-engineered ACL replacements that have the potential to mimic the native ACL in terms of both biological and mechanical properties. This article reviews the current literature regarding contemporary tissue engineering strategies. The four basic components of tissue engineering, biomaterial scaffolds, cell sources, growth factors, and mechanical stimuli, as applied to the development of tissue-engineered ACL replacement grafts, will be systematically addressed. In addition, animal models that have been used to test these tissue-engineered ACL replacements will also be reviewed. To date, there is no tissue-engineered ACL construct that has been successfully implanted in humans. We expect that continued progress in designing a viable tissue-engineered ACL replacement will accompany rapidly advancing techniques in materials science and biology.

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Augmentation in anterior cruciate ligament reconstruction—a histological and biomechanical study on goats

Cited by 31 publications

References 19 publications

Bioactive scaffolds for bone and ligament tissue

Bioactive scaffolds for bone and ligament tissue

A Systematic Review for Anterior Cruciate Ligament Reconstruction

Current tissue engineering strategies in anterior cruciate ligament reconstruction

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