Augmentation of ADCC in mice by microbial fractions

Richman, Stephen P.; Chism, V. T.; Murphy, Samuel G.

doi:10.1007/bf00199496

Cited by 3 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tumor cells can be eliminated in the presence of specific antibody [23], and antibody-mediated cytotoxicity is augmented by microbial agents [2,21]. Since most PBAs induce differentiation of B lymphocytes into antibody-producing cells [5,12], MA could accentuate the B cell response to weakly immunogenic molecules such as tumor-associated antigens by triggering appropriate clones of antibody-producing cells.…”

Section: Discussionmentioning

confidence: 99%

Menningococcal antigens (MA): A novel immune stimulant in experimental neoplasia

Teodorczyk-Injeyan

Sparkes²,

Dupuy

et al. 1983

Cancer Immunol Immunother

View full text Add to dashboard Cite

An extract of the meningococcus antigens (MA) prepared from N. meningitidis was tested for an anti-tumor effect in rat and murine metastasizing tumor models. Effectiveness of MA in each model varied with dose and was manifested as significantly improved survival of the treated animals. Growth of the primary Fischer bladder carcinoma (FBCa) and metastases to lungs and lymph nodes were significantly inhibited in F344 rats treated weekly with 1 mg MA. Administration of MA at 100 micrograms per animal significantly prolonged survival of P815 mastocytoma-inoculated DBA/2 mice. Survival of C-26 colon adenocarcinoma-bearing Balb/c mice was significantly improved in animals that received weekly injections of 20 micrograms MA, without significant effect on the development of local tumor. The meningococcal antigens demonstrate strong mitogenic activity in B-cell-enriched murine spleen cultures. Thus the immunostimulatory activity of MA in experimental malignancy could involve, directly or indirectly, activation of B lymphocytes.

show abstract

Section: Discussionmentioning

confidence: 99%