Augmentation of cellular immunity and protection against influenza virus infection by bovine late colostrum in mice

Uchida, Kenji; Hiruta, Naoyuki; Yamaguchi, Hiroshi; Yamashita, Kousaku; Fujimura, Katsuyuki; Yasui, Hisako

doi:10.1016/j.nut.2011.07.021

Cited by 12 publications

(7 citation statements)

References 25 publications

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“…Uchida et al (2010) reported that treatments with SCBLC could shorten the duration of the disease in the upper respiratory tract caused by a virus (i.e., rhinovirus, coronavirus, and influenza virus) in clinical trials. Oral administration of SCBLC protects against influenza viral infection by activation of cellular immunity in vivo using a mouse model and in vitro using Murine Peyer's patch cells (Uchida et al, 2012). These findings support the hypothesis that ingestion of SCBLC can protect against various viral infections.…”

supporting

confidence: 76%

“…Skimmed and concentrated bovine late colostrum has been reported to be effective in protecting against several types of viral infections (Murakami et al, 2010;Uchida et al, 2010Uchida et al, , 2012. For example, Murakami et al (2010) demonstrated that SCBLC reduced the binding of virus-like particles of norovirus (Ueno-7k strain) and sapovirus (NK24 strain) to human intestinal Caco-2 cells in a concentration-dependent manner.…”

mentioning

confidence: 99%

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Multiple-dose therapy with bovine colostrum confers significant protection against diarrhea in a mouse model of human rotavirus-induced gastrointestinal disease

Inagaki

Yamamoto

Cairangzhuoma

et al. 2013

Journal of Dairy Science

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Rotavirus is the most important etiologic agent of severe gastroenteritis. Previously, we reported that skimmed and concentrated bovine late colostrum (SCBLC) obtained from normal unimmunized cows at 6 to 7d after parturition effectively prevented against human rotavirus (HRV)-induced severe gastroenteritis in vivo, when administered as a single dose 60 min before viral inoculation. In the present study, we examined the efficacy of multiple administrations of SCBLC at smaller dosages after viral inoculation in vivo. We demonstrate that multiple administrations within 24h after virus inoculation resulted in earlier recovery from diarrheal symptoms, in an administration frequency-dependent manner. Furthermore, we investigated whether isolated IgG anti-HRV activity in SCBLC was equivalent to that of IgG isolated from bovine mature milk as measured by in vitro activity assays. We found that IgG-containing fractions from SCBLC and mature milk exhibited approximately the same level of anti-HRV activity. We concluded that the SCBLC contains a high level of IgG against HRV-induced severe gastroenteritis, which will be possible to use in protective effects in immunocompromised hosts, such as children and the elderly. Multiple doses of SCBLC during the early stages of infection or lower dosage of SCBLC given as a single dose both resulted in relief of diarrheal symptoms.

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supporting

confidence: 76%

mentioning

confidence: 99%

Multiple-dose therapy with bovine colostrum confers significant protection against diarrhea in a mouse model of human rotavirus-induced gastrointestinal disease

Inagaki

Yamamoto

Cairangzhuoma

et al. 2013

Journal of Dairy Science

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“…Experiments in murine animal models have also found increased NKT in mice that ingested colostrum containing LPS-specific bovine IgGs ( 176 ). Similarly, increased NK activity was reported in spleen and Peyer's patch of mice that ingested bovine hyperimmune colostrum ( 121 , 143 , 177 ). It is not clear at present if these NK cells are induced by IgG or by other factors present in colostrum.In summary, Figure 2 shows the mechanism of action of bovine IgG on the immune system.…”

Section: Bovine Immunoglobulins: Putative Mechanism Of Actionsupporting

confidence: 55%

Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection

et al. 2018

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This review aims to provide an in depth overview of the current knowledge of the effects of bovine immunoglobulins on the human immune system. The stability and functional effects of orally ingested bovine immunoglobulins in milk products are described and potential mechanisms of action are discussed. Orally ingested bovine IgG (bovine IgG) can be recovered from feces, ranging from very low levels up to 50% of the ingested IgG that has passed through the gastrointestinal tract. In infants the recovered levels are higher than in adults most likely due to differences in stomach and intestinal conditions such as pH. This indicates that bovine IgG can be functionally active throughout the gastrointestinal tract. Indeed, a large number of studies in infants and adults have shown that bovine IgG (or colostrum as a rich source thereof) can prevent gastrointestinal tract infections, upper respiratory tract infections, and LPS-induced inflammation. These studies vary considerably in target group, design, source of bovine IgG, dosage, and endpoints measured making it hard to draw general conclusions on effectiveness of bovine immunoglobulin rich preparations. Typical sources of bovine IgG used in human studies are serum-derived IgG, colostrum, colostrum-derived IgG, or milk-derived immunoglobulins. In addition, many studies have used IgG from vaccinated cows, but studies using IgG from nonimmunized animals have also been reported to be effective. Mechanistically, bovine IgG binds to many human pathogens and allergens, can neutralize experimental infection of human cells, and limits gastrointestinal inflammation. Furthermore, bovine IgG binds to human Fc receptors which, enhances phagocytosis, killing of bacteria and antigen presentation and bovine IgG supports gastrointestinal barrier function in in vitro models. These mechanisms are becoming more and more established and explain why bovine IgG can have immunological effects in vivo. The inclusion of oral bovine immunoglobulins in specialized dairy products and infant nutrition may therefore be a promising approach to support immune function in vulnerable groups such as infants, children, elderly and immunocompromised patients.

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“…Similarly, the oligosaccharides in the milk can act as a decoy receptor preventing the binding of the influenza virus to the sialylated glycans on the cells [190,191]. Ruminant biological fluids/components such as bovine colostrum, amniotic fluid, mucoprotein from bovine submaxillary glands also could interfere with biological properties of influenza [192,193,194,195,196,197]. A consumable low-molecular-weight fraction (CLMWF) of immunoglobulin-depleted bovine colostrum whey, exhibited antibacterial (Streptococcus) and antiviral (influenza) immune defense in vivo, by aiding the maturation of the antigen presenting cells [198].…”

Section: Host Restriction Factors In Bovines: Sensitivity Of Influmentioning

confidence: 99%

Influenza A in Bovine Species: A Narrative Literature Review

Sreenivasan

Thomas

Kaushik

et al. 2019

Viruses

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It is quite intriguing that bovines were largely unaffected by influenza A, even though most of the domesticated and wild animals/birds at the human–animal interface succumbed to infection over the past few decades. Influenza A occurs on a very infrequent basis in bovine species and hence bovines were not considered to be susceptible hosts for influenza until the emergence of influenza D. This review describes a multifaceted chronological review of literature on influenza in cattle which comprises mainly of the natural infections/outbreaks, experimental studies, and pathological and seroepidemiological aspects of influenza A that have occurred in the past. The review also sheds light on the bovine models used in vitro and in vivo for influenza-related studies over recent years. Despite a few natural cases in the mid-twentieth century and seroprevalence of human, swine, and avian influenza viruses in bovines, the evolution and host adaptation of influenza A virus (IAV) in this species suffered a serious hindrance until the novel influenza D virus (IDV) emerged recently in cattle across the world. Supposedly, certain bovine host factors, particularly some serum components and secretory proteins, were reported to have anti-influenza properties, which could be an attributing factor for the resilient nature of bovines to IAV. Further studies are needed to identify the host-specific factors contributing to the differential pathogenetic mechanisms and disease progression of IAV in bovines compared to other susceptible mammalian hosts.

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Augmentation of cellular immunity and protection against influenza virus infection by bovine late colostrum in mice

Cited by 12 publications

References 25 publications

Multiple-dose therapy with bovine colostrum confers significant protection against diarrhea in a mouse model of human rotavirus-induced gastrointestinal disease

Multiple-dose therapy with bovine colostrum confers significant protection against diarrhea in a mouse model of human rotavirus-induced gastrointestinal disease

Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection

Influenza A in Bovine Species: A Narrative Literature Review

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