Augmentation of serotonin in the developing superior colliculus alters the normal development of the uncrossed retinotectal projection

Mooney, Richard; Crnko-Hoppenjans, Tracy A.; Ke, Min; Bennett‐Clarke, Carol A.; Lane, Richard D.; Chiaia, Nicolas L.; Rhoades, Robert W.

doi:10.1002/(sici)1096-9861(19980330)393:1<84::aid-cne8>3.0.co;2-m

Cited by 20 publications

(3 citation statements)

References 26 publications

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“…Numerous studies have suggested that, in addition to its actions as a neuromodulator in adult nervous systems, serotonin plays important roles in the development of neuronal circuits. For example, serotonin influences process outgrowth and synapse formation (Haydon et al, 1984;Goldberg and Kater, 1989;Diefenbach et al, 1995;Mercer et al, 1996), and the manipulation of serotonin levels during development alters the structure and function of identified neurons and connections (Mooney et al, 1998;Persico et al, 2000;Sullivan et al, 2000;Benton and Beltz, 2001). This suggests that serotonin might play a developmental role in the stomatogastric nervous system at the time it first appears, around the second larval stage.…”

Section: Introductionmentioning

confidence: 99%

Serotonin in the developing stomatogastric system of the lobster, Homarus americanus

et al. 2002

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We studied the development of the serotonergic modulation of the stomatogastric nervous system of the lobster, Homarus americanus. Although the stomatogastric ganglion (STG) is present early in embryonic development, serotonin immunoreactivity is not visible in the STG until the second larval stage. However, incubation of the STG with exogenous serotonin showed that a serotonin transporter is present in embryonic and early larval stages. Serotonin uptake was blocked by paroxetine and 0% Na(+) saline. The presence of a serotonin transporter in the embryonic STG suggests that hormonally liberated serotonin could be taken up by the STG, and potentially released as a "borrowed transmitter". Consistent with a potential hormonal role, serotonin is found in the pericardial organs, a major neurosecretory structure, by midembryonic development. The rhythmic motor patterns produced by embryonic and larval STGs were decreased in frequency by serotonin. Lateral Pyloric (LP) neuron-evoked excitatory junctional potentials (EJPs) in the embryos and the first larval stage (LI) were larger, slower, and more variable than those in the adult. The amplitude of adult LP neuron-evoked EJPs was increased more than twofold in serotonin, but in embryos and LI preparations this effect was negligible. In embryos and LI preparations, serotonin increased the occurrence of muscle fiber action potentials and altered the EJP wave-form. These data demonstrate that serotonin receptors are present in the stomatogastric nervous system early in development, and suggest that the role of serotonin changes from modulation of muscle fiber excitability early in development to enhancement of neurally evoked EJPs in the adult.

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Section: Introductionmentioning

confidence: 99%

Serotonin in the developing stomatogastric system of the lobster, Homarus americanus

et al. 2002

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“…For this reason, it would be valuable to distinguish hippocampal connections using in vivo imaging methods. This rationale is reinforced by tracer studies in animals showing that individual hippocampal neurons rarely contribute axons to both the precommissural and postcommissural fornix ( Donovan and Wyss, 1983 , Naber and Witter, 1998 ).…”

Section: Discussionmentioning

confidence: 99%

The status of the precommissural and postcommissural fornix in normal ageing and mild cognitive impairment: An MRI tractography study

et al. 2016

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The fornix connects the hippocampal formation with structures beyond the temporal lobe. Previous tractography studies have typically reconstructed the fornix as one unified bundle. However, the fornix contains two rostral divisions: the precommissural fornix and the postcommissural fornix. Each division has distinct anatomical connections and, hence, potentially distinct functions. Diffusion weighted MRI and spherical deconvolution based tractography were employed to reconstruct these separate fornix divisions and to examine their microstructural properties in both healthy ageing and Mild Cognitive Impairment (MCI). Reliable reconstructions of precommissural and postcommissural fibres were achieved in both groups, with their fibres retaining largely separate locations within the anterior body of the fornix. Ageing and MCI had comparable effects on the two segments. Ageing was associated with changes in mean, axial and radial diffusivity but not with alterations of fibre population-specific diffusion properties, estimated with the hindrance modulated orientational anisotropy (HMOA). Individual HMOA variation in postcommissural, but not precommissural, fibres correlated positively (and unrelated to age) with visual recall performance. This provides novel evidence for a role of postcommissural fibres, which connect structures of the extended hippocampal network, in episodic memory function. Separating the fornix into its two principal divisions brings new opportunities for distinguishing different hippocampal networks.

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“…The serotonergic transmitter system modulates many physiological functions such as mood, sexual behavior, feeding, sleep/wake cycle, memory, cognition, blood pressure regulation, breathing, and reproductive success (Mooney et al, 1998; Abrams et al, 2004; Lechin et al, 2006; Lerch-Haner et al, 2008; McDevitt and Neumaier, 2011). Because of the complexity and variety of the different behaviors modulated by serotonin, it is expected that modulatory signals from other brain areas including sensory information is integrated by GPCR signals in nuclei containing 5-HT neurons using a high diversity of GPCRs.…”

Section: Integration and Signal Processing Of Modulatory Information mentioning

confidence: 99%

Modulation of firing and synaptic transmission of serotonergic neurons by intrinsic G protein-coupled receptors and ion channels

Maejima¹,

Masseck²,

Mark³

et al. 2013

Front. Integr. Neurosci.

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Serotonergic neurons project to virtually all regions of the central nervous system and are consequently involved in many critical physiological functions such as mood, sexual behavior, feeding, sleep/wake cycle, memory, cognition, blood pressure regulation, breathing, and reproductive success. Therefore, serotonin release and serotonergic neuronal activity have to be precisely controlled and modulated by interacting brain circuits to adapt to specific emotional and environmental states. We will review the current knowledge about G protein-coupled receptors and ion channels involved in the regulation of serotonergic system, how their regulation is modulating the intrinsic activity of serotonergic neurons and its transmitter release and will discuss the latest methods for controlling the modulation of serotonin release and intracellular signaling in serotonergic neurons in vitro and in vivo.

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Augmentation of serotonin in the developing superior colliculus alters the normal development of the uncrossed retinotectal projection

Cited by 20 publications

References 26 publications

Serotonin in the developing stomatogastric system of the lobster, Homarus americanus

Serotonin in the developing stomatogastric system of the lobster, Homarus americanus

The status of the precommissural and postcommissural fornix in normal ageing and mild cognitive impairment: An MRI tractography study

Modulation of firing and synaptic transmission of serotonergic neurons by intrinsic G protein-coupled receptors and ion channels

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