Augmentation of thyrotropin responses to thyrotropin-releasing hormone following inorganic iodide.

Inhibitory effect of low-dose inorganic iodine on thyroidal radioactive iodine uptake in healthy Japanese adults

“…In our study slight elevation of serum TSH concentration with stable serum thyroid hormone levels was observed in heathy adults after the administration of 10 mg iodine for 2 weeks. This observation consists with previous reports [13,19]. Ikeda et al reported that under seaweed restricted diet, 10 mg KI daily for one week in 8 Japanese adults increased slightly serum TSH level without significant changes in serum T4 and T3 levels [19].…”

“…This observation consists with previous reports [13,19]. Ikeda et al reported that under seaweed restricted diet, 10 mg KI daily for one week in 8 Japanese adults increased slightly serum TSH level without significant changes in serum T4 and T3 levels [19]. However, in the present study, subclinical hypothyroidism occurred in three participants, suggesting the risk of iodine side effects might be present if administered repeatedly even in a small dose.…”

Relationship of Iodide-Induced Increase in TSH Response to TRH to Changes in Serum Thyroid Hormones

“…Our failure to find a fall in serum T3 after iodide or to find a direct correlation between the changes in serum T4 and TSH might have been due to the larger dose of iodide used in our study compared to previous ones (1,2); however, a recent report (8) has also found a poor correlation between serum thyroid hormones and TSH after using only a small dose of iodide. Most likely, serum thyroid hormones did fall in our subjects after iodide was given but were brought back to or toward normal by the rise in TSH.…”

Thyroid-Stimulating Hormone: Neuroregulation and Clinical Applications: PART 1

“…Just as small increases in serum T, and T, levels reduce basal and TRH-stimulated levels, small decreases in T, and T, levels induced by short-term administration of pharmacological doses of iodide lead to elevation in basal and TRH-stimulated TSH levels (Saberi & Utiger, 1975;Ikeda & Nagataki, 1976;Jubiz, Carlile & Lagerquist, 1977).…”