1999
DOI: 10.1159/000008718
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Augmentative Effect of Cyclosporin A on Rat Liver Regeneration: Influence on Hepatocyte Growth Factor and Transforming Growth Factor-β<sub>1</sub>

Abstract: We investigated the effect of cyclosporin A (CsA) on rat liver regeneration following partial hepatectomy with reference to cytokine production. Rats were divided into two groups: those without CsA pretreatment (group 1) and those with CsA pretreatment (group 2). Animals were given olive oil vehicle or CsA (10 mg/kg) dissolved in olive oil daily by gavage from 4 to 1 days before hepatectomy. The ratio of regenerating liver weight to initial body weight in group 2 was significantly higher than that in group 1 a… Show more

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Cited by 11 publications
(9 citation statements)
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“…This effect may contribute to accelerate the development of hepatocellular carcinomas in rats fed a CsA diet. As previously obser ved with BR 931, a hypolipidemic peroxisome proliferator, stimulation of liver cell growth by CsA does not entail changes in the production of HGF, TGF or TGF1 [63] . In conclusion, immunosuppressive molecules such as CsA, when co-administrated with TAA-treated liver, inhibited TGF- activation by a mechanism that may involve down regulation of transglutaminase and collagen expression.…”
Section: Discussionsupporting
confidence: 70%
See 1 more Smart Citation
“…This effect may contribute to accelerate the development of hepatocellular carcinomas in rats fed a CsA diet. As previously obser ved with BR 931, a hypolipidemic peroxisome proliferator, stimulation of liver cell growth by CsA does not entail changes in the production of HGF, TGF or TGF1 [63] . In conclusion, immunosuppressive molecules such as CsA, when co-administrated with TAA-treated liver, inhibited TGF- activation by a mechanism that may involve down regulation of transglutaminase and collagen expression.…”
Section: Discussionsupporting
confidence: 70%
“…[60] ). Previous studies showed that the immunosuppressive agent CsA modulates the MDR protein P-gp and exerts a hepatotrophic influence in the regenerating liver [61][62][63] . CsA has an additive effect on the expression of P-gp during liver regeneration in the rat.…”
Section: Discussionmentioning
confidence: 99%
“…31 On the other hand, cyclosporine and tacrolimus are known to directly stimulate hepatic regeneration, and the question has been raised whether HCC might be similarly stimulated. 32 The new agent, sirolimus (rapamycin), has been shown to inhibit hepatic regeneration, 33 and it has been proposed on this basis that it may be a rational immunosuppressive agent for patients transplanted with HCC.…”
Section: Hcc and Posttransplant Immunosuppressionmentioning
confidence: 99%
“…Group 2 animals received 5 mg/kg CyA (Neoral ® , Novartis Pharma, Basel) and group 3 animals received 5 or 10 mg/kg CyA. These CyA doses were selected based on the results reported by Morii et al [6] . In each group, five rats were killed before and at day 1, 3, 7 and 14 after the hepatectomy.…”
Section: Surgical Proceduresmentioning
confidence: 99%