Augmented Activity of Cyclooxygenase‐2 in Tissue and Serum of Patients With Cervical Cancer

Jawanjal, Poonam; Salhan, Sudha; Dhawan, Indrani; Das, Nirmalendu; Aggarwal, Ruby; Tripathi, Richa; Rath, Goutam

doi:10.1002/jcla.22003

Cited by 8 publications

(3 citation statements)

References 39 publications

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“…12 An accumulation of evidence indicates that the overexpression of COX-2 in cervical carcinoma tissues is involved in the pathogenesis of cervical cancer. 13 This is consistent with a previous study, in which the polysaccharide obtained from G. lucidum regulated Bcl-2, Bax, and cleaved caspase-3 protein expression and exerted antitumor activity against HL-60 acute leukemia cells. 14 Therefore, we speculated that EGLP may inhibit tumor development via an increase in the expression of Bax and cleaved caspase-3, and a decrease in the expression of Bcl-2 and COX-2.…”

Section: Discussionsupporting

confidence: 93%

Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma–bearing mice

Kong

Yao

Zhang

2019

Int J Immunopathol Pharmacol

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Polysaccharides from Ganoderma lucidum have been demonstrated to possess diverse biological activities. Despite lots of studies on the biological activities of Ganoderma lucidum polysaccharide (GLP), little is known regarding the medicinal potential of low–molecular weight enzymatically hydrolyzed Ganoderma lucidum polysaccharide (EGLP). EGLP was prepared by enzymatic degradation and its potential effects in U14 cervical tumor–bearing mice were evaluated. Both GLP and EGLP delayed tumor growth of the tumor xenograft. The EGLP was superior to native polysaccharide. Moreover, EGLP treatment could effectively protect the immune organs of U14 cervical carcinoma–bearing mice. In addition, the EGLP treatment ameliorated oxidative stress as compared with cyclophosphamide (CTX). Compared with the MC group, the expression of Bcl-2 and COX-2 was obviously decreased by EGLP treatment, whereas the expression of Bax and cleaved caspase-3 was obviously increased. These results indicated that EGLP showed stronger antitumor activity with lower toxic effects and had the potential to be a novel antitumor agent.

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Section: Discussionsupporting

confidence: 93%

Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma–bearing mice

Kong

Yao

Zhang

2019

Int J Immunopathol Pharmacol

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“…In recent years, attention has been focused on understanding the role of inflammation in tumour biology. It is known that COX-2 plays an important role for the induction of inflammation either individually or through sustained production of PGE 2 [ 18 ]. The overexpression of COX-2 is reported in numerous human malignancies including colon, breast, lung, and prostate [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

The Prostaglandin EP3 Receptor Is an Independent Negative Prognostic Factor for Cervical Cancer Patients

Heidegger

Dietlmeier

et al. 2017

IJMS

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We know that one of the main risk factors for cervical cancer is an infection with high-risk human papillomavirus (HR-HPV). Prostaglandins and their receptors are very important for the tumour growth and tumour-associated angiogenesis. Little is known about the expression of the Prostaglandin E receptor type 3 (EP3) or the Prostaglandin (PG)E2-EP3 signalling in cervical cancer, so the aim of the study was to analyse the expression of the EP3 receptor in cervical cancer and find prognostic factors in relation to survival; EP3 immunohistological staining of 250 cervical cancer slides was performed and analysed with a semi-quantitative score. The statistical evaluation was performed with Statistical Package for the Social Sciences (SPSS) to evaluate the staining results and the survival analyses of the cervical cancer cases. A significant difference was observed in EP3 expression in Fédération Internationale de Gynécologie et d’Obstétrique (FIGO) stadium I versus FIGO stadium II–IV cases. High expression of EP3 (IRS ≥ 1.5) in cervical cancer patients was correlated with poor prognosis in overall survival rates. Survival in adenocarcinoma (AC) of the cervix was lower than in squamous cell carcinoma (SCC). Cox regression analysis shows that EP3 is an independent prognosticator. In this study we could show that the membrane-bound prostaglandin receptor EP3 is an independent prognosticator for cervical cancer patient survival. Targeting the EP3 receptor seems to be an interesting candidate for endocrine therapy. Therefore, more research is needed on the influence of the receptor system and its influence on cervical cancer growth.

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“…COX-2 inhibitors may participate in the occurrence and development of tumors through enhancing tumor nourishing angiogenesis, inhibiting immune surveillance, promoting cell proliferation, enhancing tumor invasion/metastasis or inhibiting apoptosis and therefore they are associated with the prognosis of patients with tumors (8). Studies have demonstrated that COX-2 is not expressed in normal cervical tissues, but that its expression in CC is significantly increased (9). Consequently, COX-2 inhibitors have become a focus of CC therapies (10).…”

Section: Introductionmentioning

confidence: 99%

Effect of photodynamic therapy combined with Celecoxib on expression of cyclooxygenase-2 protein in HeLa cells

Mao

Wang

et al. 2018

Oncol Lett

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Abstract. The present study assessed the effect of photodynamic therapy (PDT) combined with Celecoxib (Cel) on cervical cancer HeLa cells. An MTT assay was performed to detect the inhibitory effects of Cel with different concentrations (10, 50, 100, 150, 200, 250 and 300 µg/ml) on the proliferation of HeLa cells. Subsequently, HeLa cells were divided into control group (group H), 50 g/ml Celecoxib group (group C), PDT group (group P), 50 g/ml Cel + PDT group (group P + C) and western blotting and immunohistochemistry were performed to detect the expression of cyclooxygenase-2 (COX-2) protein in the different groups. Cel inhibited HeLa cells proliferation 24 h following administration, among which 200 µg/ml induced a 50% inhibition rate; the relative expression level of COX-2 protein in group P + C was significantly decreased compared with that in either group C or group P (P<0.05). Cel inhibited the proliferation of human cervical cancer cells in a concentration-dependent manner, and combined PDT therapy may improve treatment outcomes.

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Augmented Activity of Cyclooxygenase‐2 in Tissue and Serum of Patients With Cervical Cancer

Abstract: Augmented Cox-2 activity is implicated in the pathogenesis of cervical cancer, and its serum level could serve a potential to distinguish this malignancy. Therefore, it is suggested that serum Cox-2 may be useful in monitoring the diagnosis and treatment outcome of patients.

Cited by 8 publications

References 39 publications

Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma–bearing mice

Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma–bearing mice

The Prostaglandin EP3 Receptor Is an Independent Negative Prognostic Factor for Cervical Cancer Patients

Effect of photodynamic therapy combined with Celecoxib on expression of cyclooxygenase-2 protein in HeLa cells

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