Augmented Anabolic Responses after 8-wk Cycling with Blood Flow Restriction

Conceição, Miguel Soares; M, Edson M.; Telles, Guilherme Defante; Libardi, Cleiton Augusto; Castro, Álex; Andrade, André; Brum, Patrícia Chakur; Urias, Ursula; Kurauti, Mirian Ayumi; Costa, J. Pinto da; Boschero, Antônio Carlos; Cavaglieri, Cláudia Regina; Camera, Donny M.; Chacon-Mikahil, Mara Patrícia Traina

doi:10.1249/mss.0000000000001755

Cited by 45 publications

(90 citation statements)

References 28 publications

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“…Conceição et al., ). Furthermore, several studies demonstrate that reduced blood flow to the exercising limbs produces beneficial adaptive responses that are likely to be responsible for speeded

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kinetics, such as increased muscle oxidative enzyme activity, capillary density in quadriceps (Conceição et al., ; Esbjörnsson et al., ) and enhanced microvascular filtration capacity in humans (as an index of capillarity; Evans et al., ). Together, these factors might be responsible for speeding

{\dot{V}}_{{normalO}_{2}}

kinetics (Rossiter, ) and increasing

{\dot{V}}_{O_{2} peak}

and exercise tolerance (Abe et al., ; Kancin & Strazar, 2011; Christiansen et al., ; de Oliveira et al., ).…”

Section: Discussionmentioning

confidence: 99%

Speeding of oxygen uptake kinetics is not different following low‐intensity blood‐flow‐restricted and high‐intensity interval training

Corvino

Oliveira

Denadai

et al. 2019

Experimental Physiology

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New Findings What is the central question of this study? Can interval blood‐flow‐restricted (BFR) cycling training, undertaken at a low intensity, promote a similar adaptation to oxygen uptake (V̇normalO2) kinetics to high‐intensity interval training? What is the main finding and its importance? Speeding of pulmonary V̇normalO2 on‐kinetics in healthy young subjects was not different between low‐intensity interval BFR training and traditional high‐intensity interval training. Given that very low workloads are well tolerated during BFR cycle training and speed V̇normalO2 on‐kinetics, this training method could be used when high mechanical loads are contraindicated. Abstract Low‐intensity blood‐flow‐restricted (BFR) endurance training is effective to increase aerobic capacity. Whether it speeds pulmonary oxygen uptake (V̇O2normalp), CO2 output (V̇normalCO2normalp) and ventilatory (V̇ Ep ) kinetics has not been examined. We hypothesized that low‐intensity BFR training would reduce the phase 2 time constant (τp) of V̇O2normalp, V̇normalCO2normalp and V̇ Ep by a similar magnitude to traditional high‐intensity interval training (HIT). Low‐intensity interval training with BFR served as a control. Twenty‐four participants (25 ± 6 years old; maximal V̇normalO2 46 ± 6 ml kg−1 min−1) were assigned to one of the following: low‐intensity BFR interval training (BFR; n = 8); low‐intensity interval training without BFR (LOW; n = 7); or high‐intensity interval training without BFR (HIT; n = 9). Training was 12 sessions of two sets of five to eight × 2 min cycling and 1 min resting intervals. LOW and BFR were conducted at 30% of peak incremental power (Ppeak), and HIT was at ∼103% Ppeak. For BFR, cuffs were inflated on both thighs (140–200 mmHg) during exercise and deflated during rest intervals. Six moderate‐intensity step transitions (30% Ppeak) were averaged for analysis of pulmonary on‐kinetics. Both BFR (pre‐ versus post‐training τp = 18.3 ± 3.2 versus 14.5 ± 3.4 s; effect size = 1.14) and HIT (τp = 20.3 ± 4.0 versus 13.1 ± 2.9 s; effect size = 1.75) reduced the V̇O2normalp τp (P < 0.05). As expected, there was no change in LOW (V̇O2normalp τp = 17.9 ± 6.2 versus 17.7 ± 4.3 s; P = 0.9). The kinetics of V̇normalCO2normalp and V̇ Ep were speeded only after HIT (38.5 ± 10.6%, P < 0.001 and 31.2 ± 24.7%, P = 0.004, respectively). Both HIT and low‐intensity BFR training were effective in speeding moderate‐intensity V̇O2normalp kinetics. These data support the findings of others that low‐intensity cycling training with BFR increases muscle oxidative capacity.

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{\dot{V}}_{O_{2} normalp}

{\dot{V}}_{{normalO}_{2}}

kinetics (Rossiter, ) and increasing

{\dot{V}}_{O_{2} peak}

and exercise tolerance (Abe et al., ; Kancin & Strazar, 2011; Christiansen et al., ; de Oliveira et al., ).…”

Section: Discussionmentioning

confidence: 99%

Speeding of oxygen uptake kinetics is not different following low‐intensity blood‐flow‐restricted and high‐intensity interval training

Corvino

Oliveira

Denadai

et al. 2019

Experimental Physiology

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“…There is a lack of studies investigating whether different occlusion pressures could interfere on muscle and cardiorespiratory adaptations when undergoing ET‐BFR. Our study suggested that 80% of individual's arterial blood pressure is effective to increase muscle strength, hypertrophy, and VO 2 max after a ET‐BFR protocol …”

Section: Training Guidelinesmentioning

confidence: 68%

“…Our study suggested that 80% of individual's arterial blood pressure is effective to increase muscle strength, hypertrophy, and VO 2 max after a ET-BFR protocol. 48 Although cuff width may change the relative pressure, our meta-analysis showed that using wide or narrow cuffs in a RT-BFR protocol produces similar muscle hypertrophy compared with high RT. 42 Regarding the number of sets and repetitions in a typical RT-BFR session, the standard protocol is performing four sets (1st set-30 repetitions, 2nd set-15 repetitions, 3rd set-15 repetitions, and 4th set-15 repetitions) 28,40 with 30-60 s of interval between sets.…”

Section: Training Guidelinesmentioning

confidence: 72%

“…However, when ET is performed with BFR (ET‐BFR), there is a significant increase in aerobic power (i.e. maximum oxygen consumption

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O 2 max), as well as increases in muscle strength and hypertrophy . In young subjects (~23 years), Abe et al .…”

Section: Rationale To the Application Of Partial Blood Flow Restrictimentioning

confidence: 99%

“…maximum oxygen consumption _ VO 2 max), as well as increases in muscle strength and hypertrophy. [45][46][47][48] In young subjects (~23 years), Abe et al 45 reported that 24 ET-BFR sessions (15 min cycling at 40% of _ VO 2 max) increased muscle strength by 7.7%, muscle hypertrophy by 5.1%, and _ V O 2 max by 6.4%, suggesting BFR caused the metabolic disruption required to enhance exercise-induced adaptations. Additionally, we compared the effects of three training interventions-low intensity ET-BFR and high intensity RT and ET -on muscle strength and hypertrophy, and aerobic power ( _ VO 2 max).…”

mentioning

confidence: 99%

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Exercise with blood flow restriction: an effective alternative for the non‐pharmaceutical treatment for muscle wasting

Conceição

Ugrinowitsch

2019

J cachexia sarcopenia muscle

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Significant muscle wasting is generally experienced by ill and bed rest patients and older people. Muscle wasting leads to significant decrements in muscle strength, cardiorespiratory, and functional capacity, which increase mortality rates. As a consequence, different interventions have been tested to minimize muscle wasting. In this regard, blood flow restriction (BFR) has been used as a novel therapeutic approach to mitigate the burden associated with muscle waste conditions. Evidence has shown that BFR per se can counteract muscle wasting during immobilization or bed rest. Moreover, BFR has also been applied while performing low intensity resistance and endurance exercises and produced increases in muscle strength and mass. Endurance training with BFR has also been proved to increase cardiorespiratory fitness. Thus, frail patients can benefit from exercising with BFR due to the lower cardiovascular and join stress compared with traditional high intensity exercises. Therefore, low intensity resistance and endurance training combined with BFR may be considered as a novel and attractive intervention to counteract muscle wasting and to decrease the burden associated with this condition.

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