Augmented cAMP Signaling by Co-Administration of Resvera-trol and Curcumin: A Cellular Biosensor Kinetic Assessment

Safavifar, Farnaz; Saadat, Farshid; Jalali, Seyedeh Zohreh; Khoramizadeh, Mohammad Reza

doi:10.18502/ijph.v48i7.2958

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…High levels of cAMP, which maintains oocytes in a meiotic arrested state within follicular. Importantly, there exists reciprocal relationship between cAMP and SIRT1, whereby cAMP enhances SIRT1 signaling, While SIRT1 ensures the maintenance of high cAMP levels 141 , 142 .…”

Section: Srt2104 In Female Reproductive System Diseasesmentioning

confidence: 99%

Emerging roles of SIRT1 activator, SRT2104, in disease treatment

Chang,

Li,

Lin

et al. 2024

Sci Rep

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Silent information regulator 1 (SIRT1) is a NAD+-dependent class III deacetylase that plays important roles in the pathogenesis of numerous diseases, positioning it as a prime candidate for therapeutic intervention. Among its modulators, SRT2104 emerges as the most specific small molecule activator of SIRT1, currently advancing into the clinical translation phase. The primary objective of this review is to evaluate the emerging roles of SRT2104, and to explore its potential as a therapeutic agent in various diseases. In the present review, we systematically summarized the findings from an extensive array of literature sources including the progress of its application in disease treatment and its potential molecular mechanisms by reviewing the literature published in databases such as PubMed, Web of Science, and the World Health Organization International Clinical Trials Registry Platform. We focuses on the strides made in employing SRT2104 for disease treatment, elucidating its potential molecular underpinnings based on preclinical and clinical research data. The findings reveal that SRT2104, as a potent SIRT1 activator, holds considerable therapeutic potential, particularly in modulating metabolic and longevity-related pathways. This review establishes SRT2104 as a leading SIRT1 activator with significant therapeutic promise.

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Section: Srt2104 In Female Reproductive System Diseasesmentioning

confidence: 99%

Emerging roles of SIRT1 activator, SRT2104, in disease treatment

Chang,

Li,

Lin

et al. 2024

Sci Rep

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show abstract

“…In the arteriovenous shunt model, salvianolic acid A significantly inhibited the activation and aggregation of platelets stimulated by various agonists, and its underlying mechanism may involve the induction of cAMP [ 45 ]. Similarly, dimethyl fumarate, resveratrol, and curcumin have been shown to regulate cAMP levels [ 46 , 47 ].…”

Section: The Mechanisms Underlying the Antiplatelet Effect Of Pbcrbscmmentioning

confidence: 99%

Combined Therapy with Traditional Chinese Medicine and Antiplatelet Drugs for Ischemic Heart Disease: Mechanism, Efficacy, and Safety

Zhang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Ischemic heart disease is a significant risk factor that threatens human health, and antiplatelet drugs are routinely used to treat cases in clinical settings. Chinese medicine for promoting blood circulation and removing blood stasis (PBCRBSCM) can often be combined with antiplatelet drugs to treat ischemic heart disease. PBCRBSCM can inhibit platelet adhesion, activation, and aggregation; moreover, PBCRBSCM in combination with antiplatelet drugs exerts antiplatelet effects. The mechanism is related to several factors, including the inhibition of platelet activation and aggregation, improvement of the hemodynamic status and coagulation function, and correction of metabolism and inflammation. PBCRBSCM can also regulate the absorption and metabolism of conventional antiplatelet drugs and protect the gastric mucosal epithelial cells against damage induced by conventional antiplatelet drugs. Randomized controlled trials have confirmed that PBCRBSCM preparations and the active ingredients in these preparations can reduce resistance to aspirin and clopidogrel so that the combination of these drugs can exert their antiplatelet effects. In the perioperative treatment of patients with stable angina pectoris, unstable angina pectoris, and acute coronary syndrome undergoing percutaneous coronary intervention therapy, preparations of the active ingredients of PBCRBSCM combined with antiplatelet drugs and other conventional Western medicine treatments have been proven effective. The efficacy and safety of such combinations have also been extensively verified. Considerable progress has been made to understand the antiplatelet mechanism of PBCRBSCM. However, most clinical studies had problems, such as limited sample size and inappropriate research design, which has limited the translational use of PBCRBSCM in antiplatelet therapy. A large-scale, multicenter, randomized controlled study with cardiovascular events as the endpoint is still to be conducted to provide evidence for the combined application of PBCRBSCM and antiplatelet drugs in the prevention and treatment of ischemic heart disease.

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“…In addition, it is reported the involvement of endoplasmic reticulum-stress in curcumin-dependent apoptosis of HL-60 cells [ 142 ] and the induction of unfolded protein response (UPR) components promoting apoptosis after the curcumin treatment in activated human CD4 + T cells promoting apoptosis [ 140 ]. It is also observed that, with the treatment of HEK-293T cells at 10 µM concentration, curcumin upregulated cAMP signaling [ 143 ].…”

Section: The Camp Signalling In the Regulation Of Mitochondrial Acmentioning

confidence: 99%

Mitochondria, Oxidative Stress, cAMP Signalling and Apoptosis: A Crossroads in Lymphocytes of Multiple Sclerosis, a Possible Role of Nutraceutics

et al. 2020

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Multiple sclerosis (MS) is a complex inflammatory and neurodegenerative chronic disease that involves the immune and central nervous systems (CNS). The pathogenesis involves the loss of blood–brain barrier integrity, resulting in the invasion of lymphocytes into the CNS with consequent tissue damage. The MS etiology is probably a combination of immunological, genetic, and environmental factors. It has been proposed that T lymphocytes have a main role in the onset and propagation of MS, leading to the inflammation of white matter and myelin sheath destruction. Cyclic AMP (cAMP), mitochondrial dysfunction, and oxidative stress exert a role in the alteration of T lymphocytes homeostasis and are involved in the apoptosis resistance of immune cells with the consequent development of autoimmune diseases. The defective apoptosis of autoreactive lymphocytes in patients with MS, allows these cells to perpetuate, within the CNS, a continuous cycle of inflammation. In this review, we discuss the involvement in MS of cAMP pathway, mitochondria, reactive oxygen species (ROS), apoptosis, and their interaction in the alteration of T lymphocytes homeostasis. In addition, we discuss a series of nutraceutical compounds that could influence these aspects.

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Augmented cAMP Signaling by Co-Administration of Resvera-trol and Curcumin: A Cellular Biosensor Kinetic Assessment

Cited by 3 publications

References 29 publications

Emerging roles of SIRT1 activator, SRT2104, in disease treatment

Emerging roles of SIRT1 activator, SRT2104, in disease treatment

Combined Therapy with Traditional Chinese Medicine and Antiplatelet Drugs for Ischemic Heart Disease: Mechanism, Efficacy, and Safety

Mitochondria, Oxidative Stress, cAMP Signalling and Apoptosis: A Crossroads in Lymphocytes of Multiple Sclerosis, a Possible Role of Nutraceutics

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