Augmented frequency and mass of LH discharged per burst are accompanied by marked disorderliness of LH secretion in adolescents with polycystic ovary syndrome

Garcia-Rudaz, M. C.; Ropelato, María Gabriela; Escobar, María Eugenia; Veldhuis, Johannes D.; Barontini, Marta

doi:10.1530/eje.0.1390621

Cited by 37 publications

(23 citation statements)

References 48 publications

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“…In addition, during the night, CPPA patients showed a higher, although nonsignificant, ApEn of LH release (increased disorderliness) than CPPB girls and healthy controls. All these findings resemble the alterations in LH secretory dynamics we previously described in adolescents girls with PCOS [6]. The LH pattern of hypersecretion and increased pulsatility during the night as well as during the day is similar to that reported by Apter et al [28] on hyperandrogenic adolescents who had a comparable chronological and gynaecological age to our patients, studied with the same LH assay (IFMA).…”

Section: Discussionsupporting

confidence: 91%

“…LH concentrations are commonly increased, whereas FSH concentrations fall within the low follicular range. Recent analyses provide evidence that elevated LH concentrations in PCOS adolescents arise from an increased frequency and mass of LH secreted per burst [6]. …”

Section: Discussionmentioning

confidence: 99%

“…Recently we have demonstrated that PCOS adolescents display a hormonal profile similar to that in PCOS women [namely high serum luteinizing hormone (LH), testosterone, androstenedione and estrone concentrations] [6]. This studyidentified accelerated frequency and augmented mass of LH discharged per burst along with marked disorderliness of LH secretion in PCOS adolescents compared with normal girls, using highly specific LH immunofluorometric assay (IFMA), deconvolution analysis to estimate LH secretory properties and approximate entropy (ApEn) to assess the orderliness of LH release [6].…”

Section: Introductionmentioning

confidence: 99%

“…This studyidentified accelerated frequency and augmented mass of LH discharged per burst along with marked disorderliness of LH secretion in PCOS adolescents compared with normal girls, using highly specific LH immunofluorometric assay (IFMA), deconvolution analysis to estimate LH secretory properties and approximate entropy (ApEn) to assess the orderliness of LH release [6]. …”

Section: Introductionmentioning

confidence: 99%

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Acceleration of Luteinizing Hormone Pulse Frequency in Adolescent Girls with a History of Central Precocious Puberty with versus without Hyperandrogenism

et al. 2007

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Some adolescents with a history of idiopathic central precocious puberty (ICPP) develop hyperandrogenism. Hypothesis: Luteinizing hormone (LH) hypersecretion could be a common mechanism underlying ICPP and polycystic ovary syndrome. Aim: To explore the GnRH-LH axis in those patients. Design: To compare overnight LH secretion in 7 healthy adolescents (CG) with that in patients with prior ICPP [5 with (CPPA) and 7 without (CPPB) hyperandrogenism]. To analyze daytime LH secretion in those patients. Methods: LH secretion was quantified by immunofluorometry and deconvolution analysis. Results: Nighttime mean LH (international units/liter) was higher in CPPA (6.9 ± 1.5) than in CPPB (3.2 ± 0.4, p < 0.05) and CG (2.9 ± 0.4, p < 0.01). Deconvolution analysis revealed a greater nighttime LH frequency (pulses/hour) both in CPPA (0.91 ± 0.06, p < 0.01) and CPPB (0.74 ± 0.02, p < 0.05) than in CG (0.45 ± 0.07). CPPA patients maintained a higher frequency than CPPB. Pulsatile LH production was greater in CPPA than in CG (50 ± 12 vs. 18 ± 3 IU/l/day, p < 0.01). Daytime mass of LH released per burst and pulsatile production rate were significantly greater in CPPA than in CPPB patients. Conclusions: Hyperandrogenic adolescents with prior ICPP show increased pulsatile LH secretion. Augmentation of LH pulsatility may predispose to or cause hyperandrogenism in some adolescents with a history of precocious puberty.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acceleration of Luteinizing Hormone Pulse Frequency in Adolescent Girls with a History of Central Precocious Puberty with versus without Hyperandrogenism

et al. 2007

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“…ovarian steroidogenesis; hyperandrogenism; androstenedione; testosterone; 17-hydroxyprogesterone; luteinizing hormone THE ETIOLOGY OF OVARIAN HYPERANDROGENEMIA in the polycystic ovary syndrome (PCOS) remains enigmatic. Previous studies have emphasized the relative roles of neuroendocrine abnormalities leading to persistent and excessive LH secretion (11,14,20,30,34) and the ovarian actions of hyperinsulinemia, a consequence of insulin resistance (4,27,35,40). Additional evidence suggests that anomalous ovarian steroidogenesis is a primary abnormality in PCOS.…”

mentioning

confidence: 99%

Exaggerated 17-hydroxyprogesterone response to intravenous infusions of recombinant human LH in women with polycystic ovary syndrome

McCartney¹,

Bellows²,

Gingrich³

et al. 2004

American Journal of Physiology-Endocrinology and Metabolism

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2003.-Studies using pharmacological gonadotropin stimulation suggest that ovarian steroidogenesis is abnormal in the polycystic ovary syndrome (PCOS). We assessed ovarian steroid secretion in response to near-physiological gonadotropin stimuli in 12 ovulatory controls and 7 women with PCOS. A gonadotropin-releasing hormone-receptor antagonist (ganirelix, 2 mg sc) was given to block endogenous LH secretion, followed by dexamethasone (0.75 mg orally) to suppress adrenal androgen secretion. After ganirelix injection (12 h), intravenous infusions of recombinant human LH (0, 10, 30, 100, and 300 IU; each over 8 min) were administered at 4-h intervals in a pseudorandomized (highest dose last) manner. Plasma LH, 17-hydroxyprogesterone (17-OHP), androstenedione, and testosterone were measured concurrently. LH dose-steroid response relationships (mean sex-steroid concentration vs. mean LH concentration over 4 h postinfusion) were examined for each subject. Linear regression of 17-OHP on LH yielded a higher (mean Ϯ SE) slope in PCOS (0.028 Ϯ 0.010 vs. 0.005 Ϯ 0.005, P Ͻ 0.05), whereas extrapolated 17-OHP at zero LH was similar. The slopes of other regressions did not differ from zero in either PCOS or controls. We conclude that near-physiological LH stimulation drives heightened 17-OHP secretion in patients with PCOS, suggesting abnormalities of early steps of ovarian steroidogenesis. With the exception of 17-OHP response in PCOS, no acute LH dose-ovarian steroid responses were observed in controls or PCOS. Defining the precise mechanistic basis of heightened precursor responsiveness to LH in PCOS will require further clinical investigation. ovarian steroidogenesis; hyperandrogenism; androstenedione; testosterone; 17-hydroxyprogesterone; luteinizing hormone THE ETIOLOGY OF OVARIAN HYPERANDROGENEMIA in the polycystic ovary syndrome (PCOS) remains enigmatic. Previous studies have emphasized the relative roles of neuroendocrine abnormalities leading to persistent and excessive LH secretion (11,14,20,30,34) and the ovarian actions of hyperinsulinemia, a consequence of insulin resistance (4,27,35,40). Additional evidence suggests that anomalous ovarian steroidogenesis is a primary abnormality in PCOS. For example, theca cell cultures derived from women with PCOS secrete androgens excessively (13), even after propagation for three to four passages in LH-free media (22).In vivo studies of PCOS demonstrate characteristically abnormal ovarian steroid responses to acute administration of either a potent gonadotropin-releasing hormone (GnRH) agonist (2, 7, 15, 31, 38) or a high dose of human chorionic gonadotropin (hCG; see Ref. 12,15,19). Specifically, these stimuli elicit exaggerated secretion of 17-hydroxyprogesterone (17-OHP) and, to a lesser degree, androstenedione (⌬4A), suggesting abnormal ovarian steroidogenesis. However, these paradigms involve pharmacological ovarian stimulation and do not reproduce physiological LH pulsatility. For instance, with acute GnRH agonist administration, plasma LH approaches or exceeds 100 IU/l ...

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Impact of Chronic Training on Pituitary Hormone Secretion in the Human

Veldhuis¹,

Yoshida²

2000

Sports Endocrinology

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Augmented frequency and mass of LH discharged per burst are accompanied by marked disorderliness of LH secretion in adolescents with polycystic ovary syndrome

Cited by 37 publications

References 48 publications

Acceleration of Luteinizing Hormone Pulse Frequency in Adolescent Girls with a History of Central Precocious Puberty with versus without Hyperandrogenism

Acceleration of Luteinizing Hormone Pulse Frequency in Adolescent Girls with a History of Central Precocious Puberty with versus without Hyperandrogenism

Exaggerated 17-hydroxyprogesterone response to intravenous infusions of recombinant human LH in women with polycystic ovary syndrome

Impact of Chronic Training on Pituitary Hormone Secretion in the Human

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