Augmented immunogenicity of Lewis lung carcinoma by infection with herpes simplex virus type 2

Reiss-Gutfreund, Ruth J.; Nowotny, Norbert; Dostal, V.; Wrba, H.

doi:10.1016/0277-5379(82)90221-8

Cited by 7 publications

(5 citation statements)

References 18 publications

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“…A conceivable mechanism for the induction of tumorspecific immunity by expression of RSV-F in combination with cytokines might be the xenogenization of tumor cells by presentation of viral antigens on the cell surface in conjunction with MHC-I molecules leading to CTL-mediated tumor cell destruction (47,48).…”

Section: Discussionmentioning

confidence: 99%

Intratumoral expression of respiratory syncytial virus fusion protein in combination with cytokines encoded by adenoviral vectors asin situtumor vaccine for colorectal cancer

Hoffmann

Bayer²,

Grünwald³

et al. 2007

Molecular Cancer Therapeutics

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Section: Discussionmentioning

confidence: 99%

Intratumoral expression of respiratory syncytial virus fusion protein in combination with cytokines encoded by adenoviral vectors asin situtumor vaccine for colorectal cancer

Hoffmann

Bayer²,

Grünwald³

et al. 2007

Molecular Cancer Therapeutics

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“…For LLT, the simplest enhancement mechanism could be the infection of the cells themselves: in fact, in vitro, they sustain the synthesis of HSV-2 infectious virus particles without showing evidence of cytopathologic alterations, on the contrary, cell multiplication is stimulated [29]. This, however, cannot apply here, because HSV-2 infected LLT cells become xenogenized and thus prone to immunologic destruction whereby tumor formation is slowed rather than enhanced.…”

Section: Discussionmentioning

confidence: 78%

Enhancement of Lewis Lung Carcinoma by the Concomitant Infection of the Host with Herpes simplex Virus Type 1 and Type 2

1983

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Infection with herpes simplex virus (HSV) enhances the growth of Lewis lung tumor (LLT). Infection with HSV-1 enhances as efficiently as HSV-2. A significant acceleration of primary tumor formation was obtained. In mice, lung metastases were increased in number and size above the controls. Enhancement occurred only with high doses of infectious virus and was also obtained only when the virus infection was at a site close to that of the tumor implantation. This finding, in addition to the lack of antigenicity of LLT, is interpreted as arguing against an immunologic mechanism of the phenomenon.

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“…The infection of these cells with HSV-2 proceeds unusually insofar as no cytopathic effects are observed although infectious virus particles are produced (an approximately 50-fold increase after 3 days). In addition, cell multiplication is significantly enhanced as a result of the infection [17].…”

Section: -mentioning

confidence: 86%

Isolation and Characterization of the Growth-Stimulating Factor in Supernatants of Herpes Simplex Virus Type 2 Infected Cells

1982

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Lytic infection of CV1 cells with herpes simplex virus type 2 does not stimulate ornithine decarboxylase activity and there is no correlation between polyamines and a growth-stimulating factor (GSF) which is present in the supernatant of the cultures. The factor was partially purified by gel filtration on Sephadex G-50 and polyacrylamide gel electrophoresis. Gel filtration as well as dialysis through membranes with different pore diameters indicated a molecular weight between 3,500 and 10,000 daltons. GSF is not extracted from aqueous solutions by diethyl ether. The activity is partially sensitive to trypsin digestion and is completely destroyed by periodate oxidation. These results suggest that GSF is a glycoprotein or a glycopeptide whose mitogenic activity resides mainly in the sugar moiety.

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Augmented immunogenicity of Lewis lung carcinoma by infection with herpes simplex virus type 2

Cited by 7 publications

References 18 publications

Intratumoral expression of respiratory syncytial virus fusion protein in combination with cytokines encoded by adenoviral vectors asin situtumor vaccine for colorectal cancer

Intratumoral expression of respiratory syncytial virus fusion protein in combination with cytokines encoded by adenoviral vectors asin situtumor vaccine for colorectal cancer

Enhancement of Lewis Lung Carcinoma by the Concomitant Infection of the Host with Herpes simplex Virus Type 1 and Type 2

Isolation and Characterization of the Growth-Stimulating Factor in Supernatants of Herpes Simplex Virus Type 2 Infected Cells

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