Augmented Stress Ulcer Index and Depressed Blood Insulin/Glucagon Ratio in Rats by Draining Gastric Juice Outside Stomach

Po, Schwille; Draxler, G.; Schellerer, W; Putz, Florian

doi:10.1055/s-0028-1095815

Cited by 5 publications

(6 citation statements)

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“…From previous work with secretory (mean ulcer index approximately 25; Schwüle et al, 1977a, b) and nonsecretory stressed rats (mean ulcer index approximately 12; Schwüle et at, 1977aSchwüle et at, , 1978 and from the present study which demonstrates a further reduction of the ulcer index by i.d. HC1, there is growing evidence that diversion of gastric juice and acid inhibition by stress may disturb the normal interplay of gut hormones resulting in an increase in ulcera tion.…”

Section: Discussionmentioning

confidence: 50%

Gastric Stress Ulcers and Gastrointestinal Hormones -Response to Hydrochloric Acid and Sodium Chloride Infused Intraduodenally

Schwille¹,

Putz²,

Bloom³

et al. 1980

Eur Surg Res

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Gastric stress ulcers were produced by restraint in nonsecretory rats, and the response of the ulcer index to intraduodenal hydrochloric acid (HCl) or sodium chloride (NaCl) was studied in a three-step dose-response trial. Both substances lowered the ulcer index dose-dependently (K_m HCl 0.038 ± 0.006; K_m NaCl 0.089 ± 0.009 mAM/kg/h, respectively) reaching a nadir in rats receiving HCl. The improvement in ulcerations was associated with elevated plasma secretin, glucose, and lowered gastrin in this protocol. In both experimental procedures plasma vasoactive intestinal peptide (VIP) was higher with the low and intermediate doses as compared with the high dose when a slight venous hyperosmolality was present. Glucagon and insulin remained essentially stable. It is concluded that stress ulcers of the restraint type may be prevented by intraduodenal HCl, suggesting that the interplay of gastrointestinal hormones is deranged by stress and partly restored by acid instillation.

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Section: Discussionmentioning

confidence: 50%

Gastric Stress Ulcers and Gastrointestinal Hormones -Response to Hydrochloric Acid and Sodium Chloride Infused Intraduodenally

Schwille¹,

Putz²,

Bloom³

et al. 1980

Eur Surg Res

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“…As occurrence in blood of substances interfering with chemical analysis is unlikely, the degree of uricemia with our control conditions, i.e., 8 h arrest of free movements and gastric fistula draining outside, is consistent with stress hyperuricemia. This conclusion is strongly supported by the blank study: these animals, in terms of ulcer index, must have been exposed to a considerably smaller total load of stress [23] and this situation is associated with lower serum uric acid (mean values 1.5--1.6 mg/dl). Such blank rats exhibit signs of a more anabolic hepatic glucose regulation [23].…”

Section: Discussionmentioning

confidence: 55%

“…Closure of fistula revealed to be a hitherto unrecognized variable in research work dealing with pathogenesis of stress ulcers: preservation of normal gastroduodenal acid transit reduces the total load of stress and mucosal damage under otherwise identical conditions [23]. Besides acid production (volume, acidity, secretion/unit time) excretion of uric acid and the MBF marker 14C-aminopyrine 2 into gastric juice were determined.…”

Section: Animals and Methodsmentioning

confidence: 99%

Urate metabolism and gastric ulcerations in rats as influenced by stress and allopurinol

et al. 1978

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Stress and allopurinol (ALL) were investigated in rats with regard to their influence on serum uric acid and glucose concentration, gastric secretion, microcirculation (MBF) and stress ulcer index. There is a non-competitive type of interaction between severe stress and ALL-mediated xanthine oxydase inhibition (= per cent fall in serum uric acid) as compared with control conditions (= mild stress). Vmax is different (84.6 +/- 1.9 and 92.3+/-2.26; P less than 0.05), but not Km (0.39 +/- 0.09 and 0.68 +/- 0.08 mg/kg/h ALL). Serum uric acid is higher in rats with draining gastric fistula than those with closed fistula suggesting that already mild stress is associated with an increase in uricemia in this species. ALL does not significantly alter gastric acid and uric acid secretion but improves markedly gastric ulcer index during mild and severe stress. Since MBF is significantly elevated by ALL during the latter circumstances, a dissociation between MBF and acid secretion is one feature of ALL actions and might become a primary aim in treatment of this disorder.

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“…In non-secretory rats systemic gastrin is in an order of magnitude reported by us [17,18] and others [16] while porto-systemic gradients have been rarely studied.…”

Section: Gastrin Concentration In Aorta and Portal Veinsmentioning

confidence: 88%

Gastric secretion, mucosal erosions and porto-systemic gastrin gradients as influenced by different degrees of stress in the rat

1981

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Gastric fistula rats (n = 79) were either left as unstressed (fistula closed) controls or gastric secretion, microcirculation (MBF), mucosal stress ulcers were studied in secretory rats subjected to zero (= freely movements allowed), mild, severe restraint stress for 8 h. In all rats gastrin in portal vein and aorta was measured in addition after discontinuation of either protocol. Acid secretion and MBF are progressively reduced by increasing stress. Pepsin and sodium are elevated with severe, acid concentration with mild stress. Pepsin and sodium are elevated with severe, acid concentration with mild stress. Serum gastrin (controls - aorta 53+/- SEM 5, portal vein 73 +/- 9 pg/ml) rises sharply in portal and systemic blood with institution of acid diversion via the outside (zero stress - 136 +/- 21, 398 +/- 98 pg/ml), but declines with increasing stress (severe stress - 82 +/- 16, 101 +/- 27 pg/ml) despite otherwise identical experimental conditions. It is concluded that (1) acid secretion rate and MBF are lowered by stress, but stress ulcers are associated with either increased acidity (mild stress) or peptic activity (severe stress) of gastric juice in the absence of elevated gastrin, (2) enhanced sodium fluxes via gastric lumen and lower acid suggest disruption if mucosal barrier by severe stress, and (3) restraint stress ulcers may be the expression of a combination of disturbances, mainly of metabolic and endocrine nature.

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Augmented Stress Ulcer Index and Depressed Blood Insulin/Glucagon Ratio in Rats by Draining Gastric Juice Outside Stomach

Cited by 5 publications

References 0 publications

Gastric Stress Ulcers and Gastrointestinal Hormones -Response to Hydrochloric Acid and Sodium Chloride Infused Intraduodenally

Gastric Stress Ulcers and Gastrointestinal Hormones -Response to Hydrochloric Acid and Sodium Chloride Infused Intraduodenally

Urate metabolism and gastric ulcerations in rats as influenced by stress and allopurinol

Gastric secretion, mucosal erosions and porto-systemic gastrin gradients as influenced by different degrees of stress in the rat

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