Augmenting - Reducing Response to Auditory Evoked Potentials and its Relationship to the Prophylactic Effect of Lithium Salts

Hegerl, Ulrich; Ulrich, G.; Müller‐Oerlinghausen, B.

doi:10.1055/s-2007-1017231

Cited by 3 publications

(1 citation statement)

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“…The success rate of this ther apy has been found to be 55-80%, depending on the criteria applied [33], Many patients, therefore, take pro phylactic lithium medication for many months until the nonresponse becomes evident. Encouraged by the relationship between the ASF slope and the antidepressive lithium response, Hegerl et al [34,35] studied AEPs to 4 stimulus intensities in 28 outpatients who had received lithium prophylaxis for at least 5 years. The patients were divided into responders and nonresponders on the basis of whether or not they had been hospitalized for treatment of relapses during the last 5 years of lithium prophylaxis.…”

Section: Lithiummentioning

confidence: 99%

Event-Related Potentials and the Prediction of Differential Drug Response in Psychiatry

Hegerl¹,

Herrmann²

1990

Neuropsychobiology

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Differences in physiological trait or state characteristics of the organism are ultimately responsible for the wide range of interindividual variability in the clinical response to psychoactive drugs. Event-related potentials (ERPs) appear especially valuable in assessing these physiological characteristics, and might therefore be useful as predictors of the individual drug response. Seven criteria for the selection of potential predictor variables are presented. A review of the literature reveals consistent, prospective and cross-validated results concerning the prediction of the clinical response to psychostimulants in hyperkinetic children. Consistent findings have also been reported concerning the relationship between ERPs and the antidepressive as well as prophylactic effects of lithium. Relating to other aspects of drug therapy in psychiatry, there have been isolated studies describing ERP differences between responders and nonresponders. It is concluded that the use of ERPs in the prediction of differential drug response is a promising research strategy, deserving more attention. Its relevance will be seen not only in its practical value for therapeutic decisions, but also in the clarification of therapeutic mechanisms.

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Section: Lithiummentioning

confidence: 99%