Bioterrorism, the intentional release of harmful biological agents, poses a growing global threat that transcends historical precedents and theoretical concerns. In today’s interconnected world, a bioterrorist attack could have devastating consequences, ranging from mass casualties to economic disruption and political instability. The historical use of biological agents in warfare, such as the distribution of smallpox-infected blankets or the 2001 anthrax attacks, underscores the enduring nature of this threat. Advances in biotechnology, while enhancing our defensive capabilities, also present new risks, as the same technologies can be misused to create deadly pathogens. Addressing bioterrorism requires global collaboration, robust biosecurity measures, and continuous vigilance to detect, prevent, and respond effectively to potential threats. As bioterrorism evolves alongside technological advancements, it demands a multifaceted and international approach to safeguard public health and security.