AuNPs Decorated PLA Stereocomplex Micelles for Synergetic Photothermal and Chemotherapy

Fan, Xiaoshan; Luo, Zheng; Ye, Enyi; You, Mingliang; Liu, Minting; Ye, Yun; Loh, Xian Jun; Wu, Yue; Liu, Yupeng

doi:10.1002/mabi.202100062

Cited by 7 publications

(2 citation statements)

References 38 publications

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“…Molecular stereocomplexation enhances the ity of encapsulated ferrite-based nanoparticles, which could be used as magneti nance contrast agents in cancer diagnosis applications [120]. Stereocomplex micelle also be used as nanocarriers for gold nanoparticles in photothermal cancer treatme chemotherapy [123]. Reproduced from [93], with permission from American Chemical Society, 2023.…”

Section: Properties and Applications Of Stereo-nano Plamentioning

confidence: 99%

Development of Stereocomplex Polylactide Nanocomposites as an Advanced Class of Biomaterials—A Review

Samsuri

Purnama

2023

Polymers

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This review paper analyzes the development of advanced class polylactide (PLA) materials through a combination of stereocomplexation and nanocomposites approaches. The similarities in these approaches provide the opportunity to generate an advanced stereocomplex PLA nanocomposite (stereo-nano PLA) material with various beneficial properties. As a potential “green” polymer with tunable characteristics (e.g., modifiable molecular structure and organic–inorganic miscibility), stereo-nano PLA could be used for various advanced applications. The molecular structure modification of PLA homopolymers and nanoparticles in stereo-nano PLA materials enables us to encounter stereocomplexation and nanocomposites constraints. The hydrogen bonding of D- and L-lactide fragments aids in the formation of stereococomplex crystallites, while the hetero-nucleation capabilities of nanofillers result in a synergism that improves the physical, thermal, and mechanical properties of materials, including stereocomplex memory (melt stability) and nanoparticle dispersion. The special properties of selected nanoparticles also allow the production of stereo-nano PLA materials with distinctive characteristics, such as electrical conductivity, anti-inflammatory, and anti-bacterial properties. The D- and L-lactide chains in PLA copolymers provide self-assembly capabilities to form stable nanocarrier micelles for encapsulating nanoparticles. This development of advanced stereo-nano PLA with biodegradability, biocompatibility, and tunability properties shows potential for use in wider and advanced applications as a high-performance material, in engineering field, electronic, medical device, biomedical, diagnosis, and therapeutic applications.

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Section: Properties and Applications Of Stereo-nano Plamentioning

confidence: 99%

Development of Stereocomplex Polylactide Nanocomposites as an Advanced Class of Biomaterials—A Review

Samsuri

Purnama

2023

Polymers

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“…Cellular thermal damage is caused by the photothermal properties of GNRs. The increase in temperature facilitates the release of GAQZ, amplifying the therapeutic effectiveness of GADZ via dual mechanisms and intensifying its cytotoxic effect on tumor cells. − …”

Section: Introductionmentioning

confidence: 99%

Combined Photothermal/Combination Chemotherapeutic Approach Using Zif-8-Supported Artesunate and Gold Nanorods

Li,

Wang,

et al. 2024

ACS Appl. Nano Mater.

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Tumors pose a significant threat to human wellbeing, presenting substantial risks to lives. Conventional approaches to cancer treatment exhibit limited efficacy in eliminating the disease, leading to undesirable outcomes and an increased likelihood of disease relapse. The application of chemotherapy and photothermal therapy has recently shown an increasing trend, owing to their limited negative effects and exceptional specificity. Chemotherapy can potentially induce a rapid reduction in tumors during initial treatment. However, it carries the risk of inducing drug resistance, ultimately contributing to tumor recurrence. Combination therapy offers more advantages, than single chemotherapy. Photothermotherapy and photodynamic therapy have gained significant public interest as innovative approaches to medical treatment. Nonetheless, gold nanorods demonstrate notable potential as exceptional photothermal agents in photothermal therapy. An acidic microenvironment is commonly found in tumors. With this factor considered, a tumor-specific cleavable material is used to encapsulate the drug for facilitating controlled release exclusively within the tumor microenvironment. The combination of dequalinium chloride and artesunate increases its selectivity toward mitochondria, enhancing its effectiveness as a chemotherapy agent. The gold nanorods were successfully employed to encapsulate the drug with ZIF-8, enabling precise transportation to the tumor location while preserving its stability. The therapeutic effectiveness of the treatment on mouse models with NCI-H1299 tumors was highly satisfactory, also demonstrating high biological safety, revealing its potential capabilities in cancer therapy. It provides a research basis for nanomaterials to inhibit tumors.

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Gold Nanostructures for an Effective Bone Cancer Therapy: Numerical Simulation and Experimental Investigation

Mohammadzadeh,

Labbaf,

Kermanpur

2024

Advcd Theory and Sims

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Gold nanostructures play a crucial role in medical applications, harnessing size and shape‐dependent properties. A prominent area of research is cancer treatment through the photothermal approach. Here, numerical simulation is explored to study the impact of gold nanostructure size, shape, and laser parameters on spatiotemporal temperature patterns during photothermal therapy (PTT). Spherical, rod, star, bipyramid, and cubic nanostructures in small, medium, and large sizes underwent 150 s of laser irradiation. COMSOL software, incorporating bioheat physics, precisely gauged thermal variations. The structural characteristics notably influence the temperature profiles, with medium‐sized rod, star, and bipyramid gold nanoparticles exhibiting superior thermal properties. Experimental validation of simulations focuses on the optimal nanostructure, synthesizing through the seed growth method. Transmission electron microscopy, UV‐visible spectroscopy, and X‐ray diffraction analysis confirm its proposed characteristics. Results demonstrate a robust correlation between experimental and simulation parameters, affirming precision. Findings showcase photothermal properties in line with theoretical predictions. The aim of this study is to determine the optimal gold nanostructure for bone cancer treatment using PTT, addressing the challenges presented by the dense and resilient nature of bone tissue and deep tumor locations. By utilizing multi‐physical modeling and simulations facilitated by COMSOL software, a novel method for pre‐clinical estimation is introduced. This research provides insights into each nanoparticle‐based PTT process prior to ex vivo and in vivo studies, offering a comprehensive understanding of the interplay between nanostructure characteristics and PTT outcomes. The approach contributes to advancing the field of cancer treatment by enhancing the predictability and effectiveness of nanoparticle‐mediated PTT.

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AuNPs Decorated PLA Stereocomplex Micelles for Synergetic Photothermal and Chemotherapy

Cited by 7 publications

References 38 publications

Development of Stereocomplex Polylactide Nanocomposites as an Advanced Class of Biomaterials—A Review

Development of Stereocomplex Polylactide Nanocomposites as an Advanced Class of Biomaterials—A Review

Combined Photothermal/Combination Chemotherapeutic Approach Using Zif-8-Supported Artesunate and Gold Nanorods

Gold Nanostructures for an Effective Bone Cancer Therapy: Numerical Simulation and Experimental Investigation

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