AuNPs@PDA-PLGA nanomembrane combined with electrical stimulation promotes spinal cord injury recovery

Kong, Weijian; Li, Ronghang; Xia, Peng; S, Pan; Qi, Zhiping; Zhao, Chengliang; Fu, Chen; Yang, Xiaoyu

doi:10.1016/j.matdes.2022.110585

Cited by 12 publications

(15 citation statements)

References 54 publications

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Section: Conductive Hydrogel As a Scaffold For Sci Repairmentioning

confidence: 99%

“…Furthermore, a study reported in ref has immobilized AuNPs onto a polydopamine-poly(lactic- co -glycolic acid) (PDA-PLGA) nanomembrane combined with electrical stimulation (ES) targeted for SCI recovery (Figure ). A nanoengineered material was developed as metal NPs can permeate the blood–brain barrier due to their small size and good electrical conductivity . Moreover, the utilization of external stimuli helps boost the efficacy of local electrical stimulation and further promotes the nerve signaling pathway, which is essential for functional recovery after SCI. ,, Based on the immunofluorescence staining used to investigate neural stem cell (NSC) differentiation, the number of differentiated NSCs on pristine PLGA was the fewest, while the number of differentiated NSCs on the surface of AuNPs@PDA-PLGA was the largest and significantly more than in the PDA-PLGA membrane.…”

Section: Conductive Hydrogel As a Scaffold For Sci Repairmentioning

confidence: 99%

“…A nanoengineered material was developed as metal NPs can permeate the blood–brain barrier due to their small size and good electrical conductivity . Moreover, the utilization of external stimuli helps boost the efficacy of local electrical stimulation and further promotes the nerve signaling pathway, which is essential for functional recovery after SCI. ,, Based on the immunofluorescence staining used to investigate neural stem cell (NSC) differentiation, the number of differentiated NSCs on pristine PLGA was the fewest, while the number of differentiated NSCs on the surface of AuNPs@PDA-PLGA was the largest and significantly more than in the PDA-PLGA membrane. Notably, differentiation of NSCs was further promoted by electrical stimulation.…”

Section: Conductive Hydrogel As a Scaffold For Sci Repairmentioning

confidence: 99%

“…Neuroregeneration therapy has been widely studied including using cell-based therapies, ,,,− electrical stimulation, ,,,− and biomaterials ,,,,,− for their potential in repairing SCI. Cell-based therapies which were originally derived from stem cell transplantation studies demonstrated the promotion of axon growth and myelination.…”

Section: Introductionmentioning

confidence: 99%

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Application of Conductive Hydrogels on Spinal Cord Injury Repair: A Review

Shahemi

Mahat

Asri

et al. 2023

ACS Biomater. Sci. Eng.

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Spinal cord injury (SCI) causes severe motor or sensory damage that leads to long-term disabilities due to disruption of electrical conduction in neuronal pathways. Despite current clinical therapies being used to limit the propagation of cell or tissue damage, the need for neuroregenerative therapies remains. Conductive hydrogels have been considered a promising neuroregenerative therapy due to their ability to provide a pro-regenerative microenvironment and flexible structure, which conforms to a complex SCI lesion. Furthermore, their conductivity can be utilized for noninvasive electrical signaling in dictating neuronal cell behavior. However, the ability of hydrogels to guide directional axon growth to reach the distal end for complete nerve reconnection remains a critical challenge. In this Review, we highlight recent advances in conductive hydrogels, including the incorporation of conductive materials, fabrication techniques, and cross-linking interactions. We also discuss important characteristics for designing conductive hydrogels for directional growth and regenerative therapy. We propose insights into electrical conductivity properties in a hydrogel that could be implemented as guidance for directional cell growth for SCI applications. Specifically, we highlight the practical implications of recent findings in the field, including the potential for conductive hydrogels to be used in clinical applications. We conclude that conductive hydrogels are a promising neuroregenerative therapy for SCI and that further research is needed to optimize their design and application.

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Section: Conductive Hydrogel As a Scaffold For Sci Repairmentioning

confidence: 99%

Section: Conductive Hydrogel As a Scaffold For Sci Repairmentioning

confidence: 99%

Section: Conductive Hydrogel As a Scaffold For Sci Repairmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Application of Conductive Hydrogels on Spinal Cord Injury Repair: A Review

Shahemi

Mahat

Asri

et al. 2023

ACS Biomater. Sci. Eng.

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“…34−37 Functionalized AuNPs have been reported to possess antioxidant capabilities, effectively inhibiting the generation of oxidative stress. 38,39 Furthermore, they have demonstrated the ability to suppress inflammatory cytokines, thereby exhibiting notable antiinflammatory effects. 40 These characteristics led us to speculate that AuNPs could facilitate functional recovery after SCI by mitigating oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Advancing Spinal Cord Injury Bioimaging and Repair with Multifunctional Gold Nanodots Tracking

Wang,

Shen,

Liu

et al. 2024

ACS Appl. Mater. Interfaces

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High levels of reactive oxygen species (ROS) are known to play a critical role in the secondary cascade of spinal cord injury (SCI). The scavenging of ROS has emerged as a promising approach for alleviating acute SCI. Moreover, identifying the precise location of the SCI site remains challenging. Enhancing the visualization of the spinal cord and improving the ability to distinguish the lesion site are crucial for accurate and safe treatment. Therefore, there is an urgent clinical need to develop a biomaterial that integrates diagnosis and treatment for SCI. Herein, ultra-small-sized gold nanodots (AuNDs) were designed for dual-mode imaging-guided precision treatment of SCI. The designed AuNDs demonstrate two important functions. First, they effectively scavenge ROS, inhibit oxidative stress, reduce the infiltration of inflammatory cells, and prevent apoptosis. This leads to a significant improvement in SCI repair and promotes a functional recovery after injury. Second, leveraging their excellent dual-mode imaging capabilities, the AuNDs enable rapid and accurate identification of SCI sites. The high contrast observed between the injured and adjacent uninjured areas highlights the tremendous potential of AuNDs for SCI detection. Overall, by integrating ROS scavenging and dual-mode imaging in a single biomaterial, our work on functionalized AuNDs provides a promising strategy for the clinical diagnosis and treatment of SCI.

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Advances in Material‐Assisted Electromagnetic Neural Stimulation

Sun,

Xiao,

Chen

et al. 2024

Advanced Materials

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Bioelectricity plays a crucial role in organisms, being closely connected to neural activity and physiological processes. Disruptions in the nervous system can lead to chaotic ionic currents at the injured site, causing disturbances in the local cellular microenvironment, impairing biological pathways, and resulting in a loss of neural functions. Electromagnetic stimulation has the ability to generate internal currents, which can be utilized to counter tissue damage and aid in the restoration of movement in paralyzed limbs. By incorporating implanted materials, electromagnetic stimulation can be targeted more accurately, thereby significantly improving the effectiveness and safety of such interventions. Currently, there have been significant advancements in the development of numerous promising electromagnetic stimulation strategies with diverse materials. This review provides a comprehensive summary of the fundamental theories, neural stimulation modulating materials, material application strategies, and pre‐clinical therapeutic effects associated with electromagnetic stimulation for neural repair. It offers a thorough analysis of current techniques that employ materials to enhance electromagnetic stimulation, as well as potential therapeutic strategies for future applications.This article is protected by copyright. All rights reserved

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AuNPs@PDA-PLGA nanomembrane combined with electrical stimulation promotes spinal cord injury recovery

Cited by 12 publications

References 54 publications

Application of Conductive Hydrogels on Spinal Cord Injury Repair: A Review

Application of Conductive Hydrogels on Spinal Cord Injury Repair: A Review

Advancing Spinal Cord Injury Bioimaging and Repair with Multifunctional Gold Nanodots Tracking

Advances in Material‐Assisted Electromagnetic Neural Stimulation

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