Auraptene Inhibits Migration and Invasion of Cervical and Ovarian Cancer Cells by Repression of Matrix Metalloproteinasas 2 and 9 Activity

Jamialahmadi, Khadijeh; Salari, S H; Alamolhodaei, Nafiseh Sadat; Avan, Amir; Gholami, Leila; Karimi, Gholamreza

doi:10.3831/kpi.2018.21.021

Cited by 29 publications

(12 citation statements)

References 31 publications

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“…E, E, Z-1,3,12-Nonadecatriene-5,14-diol is known to have anti-microbial activity (23). Isoauraptene possesses anti-inflammatory, antioxidant, anti-coagulant, anti-microbial, anti-cancer, neuroprotective and immunomodulatory effects (24). γ-Sitosterol is a phytosterol known to possess antihyperglycemic, anti-apoptotic and cytotoxic effects which has been confirmed in various studies (25).…”

Section: Gc-ms Profiling Of Ethanolic Fraction Of Cmaxima Peelmentioning

confidence: 96%

Phytochemical profiling, total flavonoid, total phenolic content and in-vitro antioxidant evaluation of Citrus maxima extract

Monteiro¹,

Shetty²,

Ranjitha³

et al. 2022

Biomedicine

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Introduction and Aim: Citrus fruits are rich in polyphenolic compounds. The conventional medical system has utilized the fruit’s entire composition including the peel for its diverse biological functions. With this, the study aimed to assess and compare the phytochemical, in-vitro antioxidant analysis as well as polyphenol and flavonoid content of Citrus maxima juice, aqueous and ethanolic extracts of its pulp and peel. Materials and Methods: Qualitative phytochemical screening, total phenolic content and total flavonoid content and different in-vitro antioxidant assays like total antioxidant capacity (TAC), Ferric reducing antioxidant power assay (FRAP), 2,2-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging assay were carried out to evaluate the in-vitro antioxidant potential in the juice, aqueous and ethanolic extract of pulp and peel of C. maxima. Gas chromatography–Mass spectrometry (GC–MS) analysis was performed in the peel ethanolic extract to identify the compounds present. Results: Preliminary phytochemical analysis revealed the presence of triterpenoids and steroids, glycosides, alkaloids, flavonoids, carbohydrates and vitamin C in all the C. maxima crude extracts. Tannins were present only in pulp of ethanol extract and in both aqueous and ethanol extracts of peel. Resins were present in the juice and ethanol extract of pulp and peel. The total phenol and total flavonoid content was comparatively higher in ethanolic extracts of peel. All the extracts showed dose-dependent free radical scavenging activity. The reducing potential of the C.maxima extractives increased with the increase in its concentration. GC-MS analysis of ethanolic peel extract identified key constituents with pharmacological effects. The ethanolic peel extract showed good antioxidant activity and free radical scavenging activity when compared to other extracts. Conclusion: The results indicated that ethanolic peel extract of Citrus maxima revealed the highest presence of polyphenolic compounds, which are secondary plant metabolites with potential antioxidant activity.

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Section: Gc-ms Profiling Of Ethanolic Fraction Of Cmaxima Peelmentioning

confidence: 96%

Phytochemical profiling, total flavonoid, total phenolic content and in-vitro antioxidant evaluation of Citrus maxima extract

Monteiro¹,

Shetty²,

Ranjitha³

et al. 2022

Biomedicine

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“…Previous research has demonstrated that auraptene possesses a variety of beneficial properties, including anti‐inflammatory (Okuyama et al, 2013), antioxidant (Prince et al, 2009), anticoagulant (Wu et al, 2009), antimicrobial (Takeda et al, 2007), anti‐cancer, neuroprotective (Furukawa et al, 2012), and immunomodulatory (Soltani et al, 2010) properties. In Hela cell line migration was significantly altered at 50, 100 μM auraptene after 6 h of incubation and at 100 μM after 24 h. The migration percentage in other concentrations was also 100% after 24 h (Jamialahmadi et al, 2018).…”

Section: Monoterpenoids Modulating Metastatic Pathwaymentioning

confidence: 98%

Monoterpenoids: An upcoming class of therapeutic agents for modulating cancer metastasis

Mathur,

Meena,

Luqman

2023

Phytotherapy Research

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Monoterpenoids, a sub‐class of terpenoids, are secondary metabolites frequently extracted from the essential oils of aromatic plants. Their antitumor properties including antiproliferative, apoptotic, antiangiogenic, and antimetastatic effects along with other biological activities have been the subject of extensive study due to their diverse characteristics. In recent years, numerous investigations have been conducted to understand its potential anticancer impacts, specifically focusing on antiproliferative and apoptotic mechanisms. Metastasis, a malignancy hallmark, can exert either protective or destructive influences on tumor cells. Despite this, the potential antimetastatic and antiangiogenic attributes of monoterpenoids need further exploration. This review focuses on specific monoterpenoids, examining their effects on metastasis and relevant signaling pathways. The monoterpenoids exhibit a high level of complexity as natural products that regulate metastatic proteins through various signaling pathways, including phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin, mitogen‐activated protein kinase/extracellular signal‐regulated kinase/jun N‐terminal kinase, nuclear factor kappa B, vascular endothelial growth factor, and epithelial mesenchymal transition process. Additionally, this review delves into the biosynthesis and classification of monoterpenoids, their potential antitumor impacts on cell lines, the plant sources of monoterpenoids, and the current status of limited clinical trials investigating their efficacy against cancer. Moreover, monoterpenoids depict promising potential in preventing cancer metastasis, however, inadequate clinical trials limit their drug usage. State‐of‐the‐art techniques and technologies are being employed to overcome the challenges of utilizing monoterpenoids as an anticancer agent.

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“…Monoterpenoids Thymol [10][11][12][13][14][15][16][17][18][19], Menthol [20][21][22][23][24][25], Auraptene [26][27][28][29][30][31][32][33][34], D-limonene [35][36][37][38][39][40], Perillic acid [41,42], Ascaridole [43,44], Carvacrol [45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61]…”

Section: Classification Terpenoidsmentioning

confidence: 99%

“…Moreover, the effect of auraptene on human cervical cancer cells (HeLa cell) and ovarian cancer cells (A2780) showed growth-inhibitory effects, suppression of cell migration and metastasis. The possible anticancer effect of auraptene in these cell lines was suggested due to a decline in the expression levels of matrix metalloproteinases (MMP-2 and MMP-9) [28]. Auraptene also inhibits β-catenin T-cell factor (TCF) function in colorectal Moreover, the effect of auraptene on human cervical cancer cells (HeLa cell) and ovarian cancer cells (A2780) showed growth-inhibitory effects, suppression of cell migration and metastasis.…”

Section: Auraptenementioning

confidence: 99%

“…Auraptene also inhibits β-catenin T-cell factor (TCF) function in colorectal Moreover, the effect of auraptene on human cervical cancer cells (HeLa cell) and ovarian cancer cells (A2780) showed growth-inhibitory effects, suppression of cell migration and metastasis. The possible anticancer effect of auraptene in these cell lines was suggested due to a decline in the expression levels of matrix metalloproteinases (MMP-2 and MMP-9) [28]. Auraptene also inhibits β-catenin T-cell factor (TCF) function in colorectal cancer cells and suppresses the overexpression of c-Myc proto-oncogene.…”

Section: Auraptenementioning

confidence: 99%

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Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review

Kamran

Sinniah

Abdulghani

et al. 2022

Cancers

101

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Cancer is a life-threatening disease and is considered to be among the leading causes of death worldwide. Chemoresistance, severe toxicity, relapse and metastasis are the major obstacles in cancer therapy. Therefore, introducing new therapeutic agents for cancer remains a priority to increase the range of effective treatments. Terpenoids, a large group of secondary metabolites, are derived from plant sources and are composed of several isoprene units. The high diversity of terpenoids has drawn attention to their potential anticancer and pharmacological activities. Some terpenoids exhibit an anticancer effect by triggering various stages of cancer progression, for example, suppressing the early stage of tumorigenesis via induction of cell cycle arrest, inhibiting cancer cell differentiation and activating apoptosis. At the late stage of cancer development, certain terpenoids are able to inhibit angiogenesis and metastasis via modulation of different intracellular signaling pathways. Significant progress in the identification of the mechanism of action and signaling pathways through which terpenoids exert their anticancer effects has been highlighted. Hence, in this review, the anticancer activities of twenty-five terpenoids are discussed in detail. In addition, this review provides insights on the current clinical trials and future directions towards the development of certain terpenoids as potential anticancer agents.

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Auraptene Inhibits Migration and Invasion of Cervical and Ovarian Cancer Cells by Repression of Matrix Metalloproteinasas 2 and 9 Activity

Cited by 29 publications

References 31 publications

Phytochemical profiling, total flavonoid, total phenolic content and in-vitro antioxidant evaluation of Citrus maxima extract

Phytochemical profiling, total flavonoid, total phenolic content and in-vitro antioxidant evaluation of Citrus maxima extract

Monoterpenoids: An upcoming class of therapeutic agents for modulating cancer metastasis

Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review

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