Auricular Tissue Engineering Using Osteogenic Differentiation of Adipose Stem Cells with Small Intestine Submucosa

Lin, Chih‐Hsun; Yang, I-Chen; Tsai, Chi-Han; Fang, Hsu‐Wei; Ma, Hsu

doi:10.1097/prs.0000000000003522

Cited by 9 publications

(8 citation statements)

References 84 publications

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“…393 Human cell sources have also been investigated, where a combination of stem cells derived from the human adipose, and scaffolds derived from small intestine submucosa had been previously reported. 394 Up until now, the tissue engineering approaches reported were validated both in vitro and via using different animal models. 383,388,390 Different conditions and materials were tested on small rodents where a partial scaffold is implanted subcutaneously; however, the use of the reported results to develop a full-size human scaffold model is still very limited.…”

Section: Auricular Tissue Engineeringmentioning

confidence: 99%

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Porous biomaterials for tissue engineering: a review

et al. 2022

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Section: Auricular Tissue Engineeringmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Porous biomaterials for tissue engineering: a review

et al. 2022

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“…3 In previous studies, alizarin has been used for staining and has been widely used in experiments on osteoporosis, bone marrow growth, and calcium deposits in the skeletal and vascular systems. [4][5][6][7][8][9][10] In addition to being a dye, alizarin has unexplained biological activities. The formation of biofilms and hyphal growth in Candida albicans is inhibited by alizarin.…”

Section: Introductionmentioning

confidence: 99%

Alizarin as a New Activator of the Aryl Hydrocarbon Receptor Signaling Pathway

Kuan

Lin

et al. 2022

Natural Product Communications

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Alizarin (1,2-dihydroxyanthraquinone) is a natural red dye extracted from the roots of Rubia cordifolia L. (family Rubiaceae). Alizarin has been used as a biological red stain for calcium. The aryl hydrocarbon receptor (AhR) has critical roles in multiple physiological pathways. This study aimed to determine whether alizarin is an unreported ligand of AhR. In the present study, we investigated the effects on cytochrome P450 (CYP) 1A1 mRNA, protein expression, AhR nuclear translocation, aryl hydrocarbon response element (AHRE) reporter activity, and AhR-specific antagonist following alizarin treatment of cells of the human hepatoma cell line, HepG2, and murine hepatoma cell line, Hepa-1c1c7. Alizarin induced CYP1A1 mRNA and protein expression in HepG2 and Hep-1c1c7 cells. Such induction was not present in C4 (B13NBii1) cells, which are AhR signal deficient, C12 (B15ECiii2) cells, which reduce AhR protein levels. The alizarin-induced responses were blocked by CH-223191, which is an AhR antagonist. Alizarin, the same as with the AhR ligand, induced the nuclear localization of AhR, as well as stimulated the transcriptional activity of AHRE. The results of this study suggest that alizarin is an AhR agonist.

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“…Heatmap representing the proportion of publications by year that utilized specific translational research methodologies from construct characterization to human trial to investigate otologic tissue engineering 15,25‐35,38‐43,45,46,107‐144 …”

Section: Discussionmentioning

confidence: 99%

Tissue engineering applications in otolaryngology—The state of translation

Niermeyer

Rodman

et al. 2020

Laryngoscope Investig Oto

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While tissue engineering holds significant potential to address current limitations in reconstructive surgery of the head and neck, few constructs have made their way into routine clinical use. In this review, we aim to appraise the state of head and neck tissue engineering over the past five years, with a specific focus on otologic, nasal, craniofacial bone, and laryngotracheal applications. A comprehensive scoping search of the PubMed database was performed and over 2000 article hits were returned with 290 articles included in the final review. These publications have addressed the hallmark characteristics of tissue engineering (cellular source, scaffold, and growth signaling) for head and neck anatomical sites. While there have been promising reports of effective tissue engineered interventions in small groups of human patients, the majority of research remains constrained to in vitro and in vivo studies aimed at furthering the understanding of the biological processes involved in tissue engineering. Further, differences in functional and cosmetic properties of the ear, nose, airway, and craniofacial bone affect the emphasis of investigation at each site. While otolaryngologists currently play a role in tissue engineering translational research, continued multidisciplinary efforts will likely be required to push the state of translation towards tissue‐engineered constructs available for routine clinical use. Level of Evidence NA.

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Auricular Tissue Engineering Using Osteogenic Differentiation of Adipose Stem Cells with Small Intestine Submucosa

Abstract: Therapeutic, V.

Cited by 9 publications

References 84 publications

Porous biomaterials for tissue engineering: a review

Porous biomaterials for tissue engineering: a review

Alizarin as a New Activator of the Aryl Hydrocarbon Receptor Signaling Pathway

Tissue engineering applications in otolaryngology—The state of translation

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