Auricular vagus somatosensory evoked potentials in vascular dementia

Polak, Thomas; Markulin, Falko; Ehlis, Ann‐Christine; Metzger, Florian; Langer, J.; Ringel, Thomas M.; Fallgatter, Andreas J.

doi:10.1007/s00702-009-0202-4

Cited by 13 publications

(17 citation statements)

References 34 publications

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“…Subsequent work focused on VSEP latencies, as prolonged latencies may be indicative of a reduced myelination of the vagus nerve and a concomitant reduced conduction velocity of the nerve fibers. Prolonged latencies of the VSEPs after tVNS have been documented in elderly (Fallgatter et al, 2005) and people suffering from mild cognitive impairments and Alzheimer's disease (Polak et al, 2014(Polak et al, , 2007, but not in people with vascular dementia (Polak et al, 2009), Parkinson's disease (Weise et al, 2015) or major depression (Polak et al, 2014). Yet, it is not always the full spectrum of P1-N1-P2 potentials that is delayed after tVNS.…”

Section: Somatosensory Evoked Potentialsmentioning

confidence: 99%

Moving beyond belief: A narrative review of potential biomarkers for transcutaneous vagus nerve stimulation

et al. 2020

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Transcutaneous vagus nerve stimulation or tVNS is a non-invasive neurostimulation technique that is currently being tested as a potential treatment for a myriad of neurological and psychiatric disorders.However, the working mechanisms underlying tVNS are poorly understood, and it remains unclear whether stimulation activates the vagus nerve for every participant. Finding a biological marker of tVNS is imperative, as it can help guide research on clinical applications, and can inform researchers on optimal stimulation sites and parameters to further optimize treatment efficacy. In this narrative review, we discuss five potential biomarkers for tVNS, and review currently available evidence for these markers for both invasive and transcutaneous VNS. While some of these biomarkers hold promise from a theoretical perspective, none of the potential biomarkers provide clear and definitive indications that tVNS increases vagal activity or augments activity in the locus coeruleus-noradrenaline network. We conclude the review by providing several recommendations for how to tackle the challenges and opportunities when researching potential biomarkers for the effects of tVNS.

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Section: Somatosensory Evoked Potentialsmentioning

confidence: 99%

Moving beyond belief: A narrative review of potential biomarkers for transcutaneous vagus nerve stimulation

et al. 2020

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“…ABVN-SEP potentials occur at millisecond latencies similar to early auditory evoked potentials (AEP), indicating that they may originate from brainstem vagal nuclei [ 9 ]. Patients with Alzheimer’s disease (AD) showed prolonged latencies [ 13 ], whereas patients with vascular dementia did not [ 12 ]. These results are in line with degeneration of the vagal nuclei complex in the course of AD [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Brainstem Function with Auricular Branch of Vagus Nerve Stimulation in Parkinson’s Disease

et al. 2015

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BackgroundThe efferent dorsal motor nucleus of the vagal nuclei complex may degenerate early in the course of Parkinson’s disease (PD), while efferent nucleus ambiguous, the principal source of parasympathetic vagal neurons innervating the heart, and afferent somatosensory nuclei remain intact.ObjectiveTo obtain neurophysiological evidence related to this pattern, we tested processing of afferent sensory information transmitted via the auricular branch of the vagus nerve (ABVN) which is known to be connected to autonomic regulation of cardiac rhythm.MethodsIn this cross-sectional observational study, we recorded (i) somatosensory evoked potentials (ABVN-SEP) and (ii) cutaneo-cardioautonomic response elicited by stimulation of the ABVN (modulation of heart-rate variability (HRV index; low frequency power, ln(LF), high frequency power, ln(HF); ln(LF/HF) ratio)) in 50 PD patients and 50 age and sex matched healthy controls. Additionally, auditory evoked potentials and trigeminal nerve SEP were assessed.ResultsNeither ABVN-SEP nor any of the other functional brainstem parameters differed between patients and controls. Although HRV index was decreased in PD patients, modulation of ln(LF/HF) by ABVN-stimulation, likely indicating cardiac parasympathetic activation, did not differ between both groups.ConclusionsFindings do not point to prominent dysfunction of processing afferent information from ABVN and its connected parasympathetic cardiac pathway in PD. They are consistent with the known pattern of degeneration of the vagal nuclei complex of the brainstem.

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“…Sixthly, 3 of the AD patients and 2 of the MCI subjects had (mild to moderate) vascular lesions as revealed by an MRI or CT examination, which is no rare finding even in healthy elderly. A former study [28] showed a normal latency of VSEP in patients with vascular dementia. Although increasing age often means increasing microangiopathic lesions (without fulfilling the imaging criteria of vascular dementia), especially since MRI scanners with higher magnetic fields generate images with higher resolution, a confounding factor in the present study cannot be excluded.…”

Section: Discussionmentioning

confidence: 88%

“…This somatosensory potential is characterized by prolonged latencies with increasing age [26]. In addition, neurodegenerative processes such as AD have been found to further increase the latency of the potential, which -in contrast -could not be demonstrated for patients with cerebrovascular diseases [27,28].…”

Section: Fg Metzger and T Polak Contributed Equally To This Workmentioning

confidence: 97%

Vagus Somatosensory Evoked Potentials A Possibility for Diagnostic Improvement in Patients with Mild Cognitive Impairment

Metzger

Polak

Aghazadeh

et al. 2012

Dement Geriatr Cogn Disord

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Objective: Vagus somatosensory evoked potentials (VSEP) are far-field potentials probably generated in nuclei of then. vagus in the lower brainstem. They represent a putative, easily applicable method for discrimination between patients with Alzheimer’s disease (AD), patients with mild cognitive impairment (MCI), and healthy controls (HC). Methods: Thirteen patients with AD, 12 with MCI, and 27 age- and gender-matched HC were investigated by stimulating the cutaneous branch of the n. vagus; 8, 6, and 20, respectively, were included in the main part of the analysis. Results: In fronto-central recordings (electrode positions Fz-F4) a grading from HC over MCI to AD could be found, with a significant linear trend over the three groups and significantly increased latencies of the cognitively impaired patients but no significant difference between MCI and AD. Conclusion: The results indicate that the method of VSEP is able to discriminate between cognitively declined patients and HC, whereas no clear-cut differences were detected between MCI and AD.

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Auricular vagus somatosensory evoked potentials in vascular dementia

Cited by 13 publications

References 34 publications

Moving beyond belief: A narrative review of potential biomarkers for transcutaneous vagus nerve stimulation

Moving beyond belief: A narrative review of potential biomarkers for transcutaneous vagus nerve stimulation

Assessment of Brainstem Function with Auricular Branch of Vagus Nerve Stimulation in Parkinson’s Disease

Vagus Somatosensory Evoked Potentials A Possibility for Diagnostic Improvement in Patients with Mild Cognitive Impairment

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Auricular vagus somatosensory evoked potentials in vascular dementia

Cited by 13 publications

References 34 publications

Moving beyond belief: A narrative review of potential biomarkers for transcutaneous vagus nerve stimulation

Moving beyond belief: A narrative review of potential biomarkers for transcutaneous vagus nerve stimulation

Assessment of Brainstem Function with Auricular Branch of Vagus Nerve Stimulation in Parkinson’s Disease

Vagus Somatosensory Evoked Potentials  A Possibility for Diagnostic Improvement in Patients with Mild Cognitive Impairment

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Vagus Somatosensory Evoked Potentials A Possibility for Diagnostic Improvement in Patients with Mild Cognitive Impairment