Aurora B is required for programmed variations of cytokinesis during morphogenesis in theC. elegansembryo

Abstract

29While cytokinesis has been intensely studied, how it is executed during 30 development is not well understood, despite a long-standing appreciation that various 31 aspects of cytokinesis vary across cell and tissue types. To address this, we 32 investigated cytokinesis during the invariant C. elegans embryo lineage and found 33 several reproducibly altered parameters at different stages. During early divisions, 34 furrow ingression asymmetry and midbody inheritance is consistent, suggesting 35 specific regulation of these events. During morphogenesis, we find several 36 unexpected alterations including migration of midbodies to the apical surface during 37 epithelial polarization in different tissues. Aurora B kinase, which is essential for 38

New signaling kid on the block: the role of the postmitotic midbody in polarity, stemness, and proliferation

“…A few studies have started to answer this question. A study using Caenorhabditis elegans showed that MBs translocate and align at the intestinal lumen formation site ( Bai et al. , 2018 ).…”