2011
DOI: 10.18632/oncotarget.311
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Aurora Kinase Inhibition Overcomes Cetuximab Resistance in Squamous Cell Cancer of the Head and Neck

Abstract: Squamous cell cancer of the head and neck (SCCHN) is the sixth leading cause for cancer deaths worldwide. Despite extense knowledge of risk factors and pathogenesis about 50 percent of all patients and essentially every patient with metastatic SCCHN eventually die from this disease. We analyzed the clinical data and performed immunohistochemistry for Epidermal growth factor receptor (EGFR) and Aurora kinase A (Aurora-A) expression in 180 SCCHN patients. Patients characterized by elevated EGFR and elevated Auro… Show more

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Cited by 68 publications
(76 citation statements)
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“…49 Investigations of small molecule Aurora B therapeutics are currently on the way, as several Aurora B protein inhibitors are entering clinical trials. [54][55][56][57][58][59] However, all the research so far were all focused on the inhibition of Aurora B activity. When testing CaM inhibitors on human adenocarcinoma cell growth, only calmidazolium displayed highly potent inhibitory activity (K d = 46 nM, Fig.…”
Section: Discussionmentioning
confidence: 99%
“…49 Investigations of small molecule Aurora B therapeutics are currently on the way, as several Aurora B protein inhibitors are entering clinical trials. [54][55][56][57][58][59] However, all the research so far were all focused on the inhibition of Aurora B activity. When testing CaM inhibitors on human adenocarcinoma cell growth, only calmidazolium displayed highly potent inhibitory activity (K d = 46 nM, Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Silencing or inhibiting Aurora A kinase is effective for inhibition of growth and apoptosis in various tumor types. 36,37 However, the detailed underlying mechanism of the growth which spans a 1.8-kb sequence upstream of the first ATG, was linked to a luciferase reporter gene. Co-transfection of this plasmid and the Aurora A shRNA resulted in an approximately 5-fold increase in luciferase activity (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…In a study using squamous cell cancer of the head and neck, overexpression of Aurora kinase A is associated with an additive antiproliferative effect upon combining pan Aurora inhibitor with EGFR 19 by inducing more polyploidy. Another study used Actinomycin D in normal fibroblasts with wildtype p53 to rescue cells from VX-680-induced polyploidy and cellular abnormalities.…”
Section: The Induction Of Polyploidy or Apoptosis By The Aurora A Kinmentioning
confidence: 99%