Ausgeprägte Symptomverschlechterung bei CRPS Typ II nach einmaliger Applikation eines hochprozentigen Capsaicinpflasters

Girtler, R.; Kloimstein, Herwig; Gustorff, Burkhard

doi:10.1007/s00482-012-1268-8

Cited by 7 publications

(2 citation statements)

References 11 publications

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“…However, in order for patients to be able to tolerate capsaicin, they received regional anesthesia prior to its application [47]. A case report suggested that capsaicin actually worsens the symptoms of CRPS due to its nociceptive stimulation [48]. Our results indicate that general and CRPS-associated prescription rates in the CRPS group were significantly higher and longer (Tables 2a,b and 3) than capsaicin prescriptions in the general population, despite controversy about the use of this medication in CRPS [8,47,48].…”

Section: Discussionmentioning

confidence: 99%

“…A case report suggested that capsaicin actually worsens the symptoms of CRPS due to its nociceptive stimulation [48]. Our results indicate that general and CRPS-associated prescription rates in the CRPS group were significantly higher and longer (Tables 2a,b and 3) than capsaicin prescriptions in the general population, despite controversy about the use of this medication in CRPS [8,47,48]. However, our results also show that prescription rates remain low and short for both cases and controls, possibly due to the intolerable, painful side effects of this medication.…”

Section: Discussionmentioning

confidence: 99%

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Prescription Trends in Complex Regional Pain Syndrome: A Retrospective Case–Control Study

Shermon,

Fazio,

Shim

et al. 2023

Brain Sciences

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Objective: The objective of this study was to evaluate discrepancies in prescription trends for analgesic medications in complex regional pain syndrome (CRPS) patients based on recommendations in the literature. Design: We conducted a retrospective case–control study. Subjects: A total of 2510 CRPS patients and 2510 demographic-matched controls participated in this study. Methods: The SlicerDicer feature in Epic was used to find patients diagnosed with CRPS I or II between January 2010 and November 2022. An equal number of age-, gender-, and race-matched controls without a CRPS diagnosis were retracted from Epic. General and CRPS-associated prescription frequencies for the following classes were retrieved for both cases and controls: benzodiazepines, bisphosphonates, calcitonin, capsaicin, neuropathic pain medications, NSAIDs, opioids, and steroids. Results: A total of 740 (29%) CRPS patients and 425 (17%) controls were prescribed benzodiazepines (95% CI 0.1–0.15), 154 (6.1%) CRPS patients and 52 (2.1%) controls were prescribed capsaicin (95% CI 0.03–0.05), 1837 (73%) CRPS patients and 927 (37%) controls were prescribed neuropathic pain medications (95% CI 0.05–0.34), 1769 (70%) CRPS patients and 1217 (48%) controls were prescribed opioids (95% CI 0.19–0.25), 1095 (44%) CRPS patients and 1217 (48%) controls were prescribed steroids (95% CI 0.08–0.14), and 1638 (65%) CRPS patients and 1765 (70%) controls were prescribed NSAIDs (95% CI −0.08–0.02), p < 0.001 for all classes. With CRPS-associated prescriptions, (95% CI 0.05–0.16, p < 0.001) more CRPS patients were prescribed opioids (N = 398, 59%) than controls (N = 327, 49%). Conclusions: CRPS is difficult to treat with significant variance in suggested treatment modalities. Based on the results of our study, there is a divergence between some published recommendations and actual practice.

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