Asian Pac J Cancer Prev, 15 (21), 9505-9509
IntroductionOne-lung ventilation (OLV) has been widely applied to cardiothoracic surgery. In spite of unilateral lung ventilation during OLV, bilateral lungs are perfused, which is bound to result in reduced oxygenation, even hypoxemia (Karzai et al., 2009). Hypoxic pulmonary vasoconstriction (HPV) is a phenomenon that the body regulates respiratory and circulatory functions to maintain the oxygen supply within the normal range under the conditions of decreased oxygen partial pressure. The formation mechanism is relatively complicated. Most studies believe that HPV is the direct effect of hypoxia on pulmonary arterial smooth muscle cells and endothelial cells (Evans et al., 2011;Swenson, 2013), but the effect of intrapulmonary During OLV, ET contents were increased significantly in two groups (P<0.05), and no significant difference was presented (P>0.05). NO content in group S was obviously higher than in group N at T3 (P<0.05), whereas CGRP content in group N was markedly lower than in group S at each time point (P<0.05). Qs/Qt was significantly increased in both groups after OLV, but there was no statistical significant regarding the Qs/Qt at each time point between two groups. Conclusions: Total intravenous anesthesia combined with SGB is conducive to regulation of perioperative vasomotor cytokines in thoracotomy, and has little effect on intrapulmonary shunt at the time of OLV.