Austdiol, fulvic acid and citromycetin derivatives from an endolichenic fungus, Myxotrichum sp.

Yuan, Chao; Wang, Haiying; Wu, Changsheng; Jiao, Yang; Li, Ming; Wang, Yanyan; Wang, Shu‐Qi; Zhao, Zhong; Lou, Hongxiang

doi:10.1016/j.phytol.2013.08.011

Cited by 34 publications

(26 citation statements)

References 14 publications

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“…With the increasing availability of innovative tools capable of measuring, visualizing, and mimicking the mechanical forces exerted on cancer cells, the emerging field of cellular biomechanics has enhanced our understanding of cancer biology. [85][86][87][88][89] There are three major types of mechanical stresses experienced by cancer cells: tensile, compressive, and shear. Tensile stress arises from cellular actomyosin contraction in response to extracellular matrix (ECM) stiffness.…”

Section: Mechanical Stressmentioning

confidence: 99%

Therapeutic targeting of cellular stress responses in cancer

Chen

Xie

2018

Thoracic Cancer

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Similar to bacteria, yeast, and other organisms that have evolved pathways to respond to environmental stresses, cancer cells develop mechanisms that increase genetic diversity to facilitate adaptation to a variety of stressful conditions, including hypoxia, nutrient deprivation, exposure to DNA‐damaging agents, and immune responses. To survive, cancer cells trigger mechanisms that drive genomic instability and mutation, alter gene expression programs, and reprogram the metabolic pathways to evade growth inhibition signaling and immune surveillance. A deeper understanding of the molecular mechanisms that underlie the pathways used by cancer cells to overcome stresses will allow us to develop more efficacious strategies for cancer therapy. Herein, we overview several key stresses imposed on cancer cells, including oxidative, metabolic, mechanical, and genotoxic, and discuss the mechanisms that drive cancer cell responses. The therapeutic implications of these responses are also considered, as these factors pave the way for the targeting of stress adaption pathways in order to slow cancer progression and block resistance to therapy.

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Section: Mechanical Stressmentioning

confidence: 99%

Therapeutic targeting of cellular stress responses in cancer

Chen

Xie

2018

Thoracic Cancer

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“…In addition, an efficient method has been developed to screen for mutants capable of adapting to abnormal salt gland density . In addition to the morphology of these specialized structures, the K + /Na + ratio has been shown to play an important role in Limonium bicolor salt tolerance . Accumulation of K + in the cytoplasm and nucleus of salt gland cells is a key factor in salt secretion …”

Section: Salt Stressmentioning

confidence: 99%

“…31 In addition to the morphology of these specialized structures, the K + /Na + ratio has been shown to play an important role in Limonium bicolor salt tolerance. [102][103][104][105][106][107] Accumulation of K + in the cytoplasm and nucleus of salt gland cells is a key factor in salt secretion. 108 In addition to halophytes, many other plants also exhibit adaptations to protect against salt stress.…”

Section: Salt Stressmentioning

confidence: 99%

Molecular mechanisms underlying stress response and adaptation

Sun

Zhou

2017

Thoracic Cancer

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Environmental stresses are ubiquitous and unavoidable to all living things. Organisms respond and adapt to stresses through defined regulatory mechanisms that drive changes in gene expression, organismal morphology, or physiology. Immune responses illustrate adaptation to bacterial and viral biotic stresses in animals. Dysregulation of the genotoxic stress response system is frequently associated with various types of human cancer. With respect to plants, especially halophytes, complicated systems have been developed to allow for plant growth in high salt environments. In addition, drought, waterlogging, and low temperatures represent other common plant stresses. In this review, we summarize representative examples of organismal response and adaptation to various stresses. We also discuss the molecular mechanisms underlying the above phenomena with a focus on the improvement of organismal tolerance to unfavorable environments.

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“…For example, a wider array of plant species means a greater variety of crops (ZHAO et al, 2010a;LIU et al, 2013;WANG et al, 2014a;AN et al, 2015;DENG et al, 2016), and healthy ecosystems can better withstand and recover from a variety of disturbances (SONG & WANG, 2015). Additionally, greater species diversity ensures natural sustainability for all life forms (YUAN et al, 2013a).…”

Section: Introductionmentioning

confidence: 99%

From ecosystems to human welfare: the role and conservation of biodiversity

Zhang

Zhou

2019

Cienc. Rural

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Biodiversity plays a key role in human welfare by providing agricultural, economic, and health benefits. However, following the industrial revolution, the rapid expansion of the human population and subsequent economic activities have caused a dramatic loss in global biodiversity, resulting in significant disturbances to ecosystems and our own living conditions. Accordingly, the conservation of biodiversity has become one of the most important challenges for humanity. The vast numbers of plants, animals, and microorganisms, the enormous genetic diversity of these species and the different ecosystems to which these organisms belong are all part of a biologically diverse planet. A substantial proportion of the world’s biodiversity has been destroyed, this loss is a catastrophe for all living species, including humans. Fortunately, we are working to remedy the destruction of our ecosystems. Herein, we summarized the discovery and development of biodiversity as a field of study and discuss the importance of the genetic and metabolite diversity. We proposed potential solutions to the loss of biodiversity with the aim of facilitating further exploration and identification of biodiversity, contributing for human welfare through the conservation of human habitats.

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Austdiol, fulvic acid and citromycetin derivatives from an endolichenic fungus, Myxotrichum sp.

Cited by 34 publications

References 14 publications

Therapeutic targeting of cellular stress responses in cancer

Therapeutic targeting of cellular stress responses in cancer

Molecular mechanisms underlying stress response and adaptation

From ecosystems to human welfare: the role and conservation of biodiversity

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