Australia Antigen and Antibody in 14,379 Volunteer Blood-Donors From S.R. Macedonia

Sera from 130 patients with active chronic hepatitis from three cities in Australia were examined for the presence of Australia (Au) antigen. To increase sensitivity, most samples were tested by three methods, immuno-diffusion, immunoelectro-osmophoresis, and complement fixation, and serial samples were examined in 45 patients.The overall incidence of Au antigen in VOL. 2, NO. 3 ~~ ~ ~~ ~ 262 COOKSLEY ET AL. ~

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Hepatitis B Virus Subtypes ad and ay Among Blood Donors in the Greater Los Angeles Area

Mosley

Edwards

Wapplehorst

et al. 1974

Transfusion

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In late 1971 and 1972, one voluntary and three commercial blood banks in the Los Angeles area provided specimens from hepatitis B antigen-positive donors. These were characterized as ad or ay subtypes of hepatitis B virus. Of 202 voluntary donors, 81 per cent had subtype ad and 19 per cent subtype ay, Of 129 paid donors, 66 per cent had subtype ad and 34 per cent had subtype ay, with one commercial bank accounting entirely for the statistically significant overall difference. Analysis by sex, race, and age of donors indicated only age to be a factor in this series. Voluntary donors less than 25 years of age had a higher frequency (30%) of ay strains than did voluntary donors 25 and over (15%). Paid donors under 25 had an even higher frequency (58%) and diffrrrd significantly from the voluntary donors under 25. Paid donors 25 and over (of whom 20% had ay strains), however, did not differ significantly from unpaid donors 25 and over (15%). Thrsc findings could indicate that illicit self-injection was the immediate background causing a high frcquency of subtype ay among young donors, paid and voluntary. Rcview of available information, however, suggests that the disproportion may be an indircct rathcr than a direct cons-quence nf epidemic drug abuse. BLOOD HANKS have adopted the screening of blood donors for hepatitis B antigen (HBAg) in a n effort to prevent those cases of transfusion-associated hepatitis caused by the hepatitis B virus (HBV). It is obvious that such screening will also yield information concerning the distribution and dynamics of HBV infection in the community. ~.

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Australia Antigen and Antibody in 14,379 Volunteer Blood-Donors From S.R. Macedonia

Cited by 4 publications

References 4 publications

Hepatitis B Antigen and Antibody in Blood Donors: An Epidemiologic Study

Hepatitis B Antigen and Antibody in Blood Donors: An Epidemiologic Study

Australia Antigen in Active Chronic Hepatitis in Australia: Results in 130 Patients from three Centres*

Hepatitis B Virus Subtypes ad and ay Among Blood Donors in the Greater Los Angeles Area

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