Australia Antigen in Singapore

Yap, E. H.; Ong, Y. W.; Simons, Margaret; Okochi, Kazuo; Mayumi, Makoto; Nishioka, Kusuya

doi:10.1111/j.1423-0410.1972.tb03982.x

Cited by 17 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table III summarizes the results of some previous studies of ABO distri bution in large groups of Chinese. The frequencies obtained in this survey for individuals of all dialect groups are in close agreement with those ob tained in Singapore by C h a n [4], Y a p et al [29] and Saha et al [18]. As indicated elsewhere [10], the results of these surveys in Singapore differ quite markedly from those obtained in large surveys in Kuala Lumpur and Hong Kong by D uraisamy and A m arasingham [6] and T o n g et al [24], respec tively, and may reflect the different areas of origin of the Chinese in the three regions.…”

Section: Discussionsupporting

confidence: 89%

Blood Group Genetic Studies in an Urban Chinese Population

Hawkins¹,

Simons²

1976

Hum Hered

View full text Add to dashboard Cite

The distribution of the blood group systems ABO, Rhesus, MNSs and P was studied in all or some of 1,007 Singapore Chinese. ABO gene frequencies were found to be consistent with previous studies and did not vary significantly between dialects. An individual of phenotype A₂B was detected although the population showed no other evidence for the A₂ gene. The possible significance of this observation in terms of weak H alleles in the population is discussed. The frequencies of the MNSs genes are consistent with previous studies. Two subjects appeared to lack the N^A component of the N antigen. The frequency of the R₁ gene of the Rhesus system was lower than has been detected previously and may relate to dialect differences. No examples of the C^w antigen were detected. The P blood group distribution appears to be subject to regional variation. It is concluded that classification of Chinese into dialect groups is a useful way of assessing genetic heterogeneity.

show abstract

Section: Discussionsupporting

confidence: 89%

Blood Group Genetic Studies in an Urban Chinese Population

Hawkins¹,

Simons²

1976

Hum Hered

View full text Add to dashboard Cite

show abstract

“…Hepatitis B viral (HBV) infection is endemic to Singapore, being responsible for about 46% of all acute viral hepatitis cases (1). The prevalence of hepatitis B surface antigen (HBsAg) carriers among blood donors varies from 6-1 3 Yo, being highest in Chinese followed by Malays and Indians (2). In studies of healthy pregnant women in Singapore, the incidence of HBsAg carriers was 6.2 ?lo in Chinese, 2.3 Yo in Malays and 0.3 O/ o in Indians (3); about 33% of these carriers were also hepatitis Be antigen (HBeAg) positive (4).…”

mentioning

confidence: 99%

Immunogenicity and Safety of Low Doses of Recombinant Yeast‐Derived Hepatitis B Vaccine

et al. 1990

View full text Add to dashboard Cite

The immunogenicity and safety of recombinant yeast-derived hepatitis B vaccine given in doses of 0.6 microgram, 1.25 microgram, 2.5 micrograms and 5.0 micrograms were studied in 4 comparable groups of children aged 1-12 years. All children received three doses of vaccine at time 0, 1 month and 5 months. Immunogenicity appeared to be satisfactory in all 4 groups of children. In the early phase of the study, a dose-response relationship was observed but there was no significant difference in the geometric mean titre among all 4 groups for any period studied. Antibody levels peaked at 9 months, declining thereafter. The geometric mean titre one year after the first vaccine dose was not significantly lower than that at the peak (9 months) in any individual group studied. The second year geometric mean titre was similar in all 4 groups and lower than that of the first year. Sero-conversion with antibody titres greater than or equal to 10 mIU/ml was 100% in the 5.0 micrograms group and greater than 90% in the other 3 groups. There were no adverse reactions of any significance. The immunogenicity of recombinant yeast-derived hepatitis B vaccine was found to be adequate even at as low a dosage as 0.6 microgram when administered in a 3-dose regimen.

show abstract