Australian Association for Exercise and Sports Science position statement on exercise and asthma

Morton, Alan R.; Fitch, Kenneth D.

doi:10.1016/j.jsams.2011.02.009

Cited by 21 publications

(30 citation statements)

References 22 publications

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“…While managing the inflammatory components of allergic asthma is essentially pharmacologic, AE may serve as a complementary therapy, as results demonstrate increases in ventilation and respiratory capacities, an improvement in the patient's quality of life and decreased asthma symptoms such as dyspnea [22,23,25,31].…”

Section: Discussionmentioning

confidence: 99%

Aerobic Exercise Decreases Lung Inflammation by IgE Decrement in an OVA Mice Model

et al. 2017

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Aerobic exercise (AE) reduces lung function decline and risk of exacerbations in asthmatic patients. However, the inflammatory lung response involved in exercise during the sensitization remains unclear. Therefore, we evaluated the effects of exercise for 2 weeks in an experimental model of sensitization and single ovalbumin-challenge. Mice were divided into 4 groups: mice non-sensitized and not submitted to exercise (Sedentary, n=10); mice non-sensitized and submitted to exercise (Exercise, n=10); mice sensitized and exposed to ovalbumin (OVA, n=10); and mice sensitized, submitted to exercise and exposed to OVA (OVA+Exercise, n=10). 24 h after the OVA/saline exposure, we counted inflammatory cells from bronchoalveolar fluid (BALF), lung levels of total IgE, IL-4, IL-5, IL-10 and IL-1ra, measurements of OVA-specific IgG1 and IgE, and VEGF and NOS-2 expression via western blotting. AE reduced cell counts from BALF in the OVA group (p<0.05), total IgE, IL-4 and IL-5 lung levels and OVA-specific IgE and IgG1 titers (p<0.05). There was an increase of NOS-2 expression, IL-10 and IL-1ra lung levels in the OVA groups (p<0.05). Our results showed that AE attenuated the acute lung inflammation, suggesting immunomodulatory properties on the sensitization process in the early phases of antigen presentation in asthma.

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Section: Discussionmentioning

confidence: 99%

Aerobic Exercise Decreases Lung Inflammation by IgE Decrement in an OVA Mice Model

et al. 2017

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“…Physical exercise is a primary indication for asthma treatment (1, 2), since it is known that training on asthmatics reduces levels of both leukotrienes and endothelin (3) as well as attenuating oxidative stress markers (4). Asthmatic exercisers have a lower bronchoconstriction, even though they were without a therapy to eliminate the hyperresponsiveness of the airways.…”

Section: Introductionmentioning

confidence: 99%

“…Asthmatic exercisers have a lower bronchoconstriction, even though they were without a therapy to eliminate the hyperresponsiveness of the airways. Additionally, physical exercise improves aerobic capacity and the endurance of respiratory muscles, making asthma attacks less uncomfortable (2, 5). …”

Section: Introductionmentioning

confidence: 99%

Intensity of swimming exercise influences tracheal reactivity in rats

Brito

Silva

Souza

et al. 2015

J. Smooth Muscle Res.

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Studies that evaluate the mechanisms for increased airway responsiveness are very sparse, although there are reports of exercise-induced bronchospasm. Therefore, we have evaluated the tracheal reactivity and the rate of lipid peroxidation after different intensities of swimming exercise in rats. Thus, male Wistar rats (age 8 weeks; 250–300 g) underwent a forced swimming exercise for 1 h whilst carrying attached loads of 3, 4, 5, 6 and 8% of their body weight (groups G3, G4, G5, G6 and G8, respectively; n=5 each). Immediately after the test, the trachea of each rat was removed and suspended in an organ bath to evaluate contractile and relaxant responses. The rate of lipid peroxidation was estimated by measuring malondialdehyde levels. According to a one-way ANOVA, all trained groups showed a significant decrease in the relaxation induced by aminophylline (10−12–10−1 M) (pD2=3.1, 3.2, 3.3, 3.3 and 3.2, respectively for G3, G4, G5, G6 and G8) compared to the control group (pD2=4.6) and the Emax values of G5, G6, G8 groups were reduced by 94.2, 88.0 and 77.0%, respectively. Additionally, all trained groups showed a significant increase in contraction induced by carbachol (10−9–10−3 M) (pD2=6.0, 6.5, 6.5, 7.2 and 7.3, respectively for G3, G4, G5, G6 and G8) compared to the control group (pD2=5.7). Lipid peroxidation levels of G3, G4 and G5 were similar in both the trachea and lung, however G6 and G8 presented an increased peroxidation in the trachea. In conclusion, a single bout of swimming exercise acutely altered tracheal responsiveness in an intensity-related manner and the elevation in lipid peroxidation indicates a degree of oxidative stress involvement.

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“…However, the recommendation is conditional on controlling the intensity as a safeguard against exercise-induced bronchospasm [5, 28]. High-intensity physical activity not only carries the risk of inducing bronchospasm but also may aggravate the side effects of sympathomimetic agents and/or corticosteroids, which are taken to reduce symptoms of airway inflammation or alleviate bronchoconstriction.…”

Section: Discussionmentioning

confidence: 99%

Tai‐Chi‐Chuan Exercise Improves Pulmonary Function and Decreases Exhaled Nitric Oxide Level in Both Asthmatic and Nonasthmatic Children and Improves Quality of Life in Children with Asthma

Lin

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Tai-Chi-Chuan (TCC) is an exercise of low-to-moderate intensity which is suitable for asthmatic patients. The aim of our study is to investigate improvements of the lung function, airway inflammation, and quality of life of asthmatic children after TCC. Participants included sixty-one elementary school students and they were divided into asthmatic (n = 29) and nonasthmatic (n = 32) groups by the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Among them, 20 asthmatic and 18 nonasthmatic children volunteered to participate in a 60-minute TCC exercise weekly for 12 weeks. Baseline and postintervention assessments included forced expiratory volume in one second (FEV1), forced vital capacity (FVC), peak expiratory flow rate (PEFR), fractional exhaled nitric oxide (FeNO) level, and Standardised Pediatric Asthma Quality of Life Questionnaire (PAQLQ(S)). After intervention, the level of FeNO decreased significantly; PEFR and the FEV1/FVC also improved significantly in both asthmatic group and nonasthmatic group after TCC. The asthmatic children also had improved quality of life after TCC. The results indicated that TCC could improve the pulmonary function and decrease airway inflammation in both children with mild asthma and those without asthma. It also improves quality of life in mild asthmatic children. Nevertheless, further studies are required to determine the effect of TCC on children with moderate-to-severe asthma.

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Australian Association for Exercise and Sports Science position statement on exercise and asthma

Cited by 21 publications

References 22 publications

Aerobic Exercise Decreases Lung Inflammation by IgE Decrement in an OVA Mice Model

Aerobic Exercise Decreases Lung Inflammation by IgE Decrement in an OVA Mice Model

Intensity of swimming exercise influences tracheal reactivity in rats

Tai‐Chi‐Chuan Exercise Improves Pulmonary Function and Decreases Exhaled Nitric Oxide Level in Both Asthmatic and Nonasthmatic Children and Improves Quality of Life in Children with Asthma

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