Background: Infection prevention, control, and health workers’ safety in the face of biological agents are among the vital issues in healthcare systems across the world. Considering the high prevalence of COVID-19 infection in the world and its high mortality rate, this epidemic can be tackled to some extent through infection control in the general population and promoting the safety of health centers. This study aims to scrutinize the literature in terms of measures adopted for infection control and safety of healthcare workers in health centers during COVID-19.Methods: We searched key words related to the study namely, “prevention and control”, “safety”, “coronavirus”, “COVID-19”, and “health personnel” in PubMed, Web of Science, ScienceDirect, Scopus databases, Google Scholar, and also in Persian data bases such as SID, Magiran, Irandoc, and Iran Medex using AND/OR functions. To select the documents, the titles of the retrieved studies were first evaluated for relevance; then, the abstracts and full texts of the papers with relevant titles were inspected. Results: Out of 136 retrieved studies, 10 were relevant and their data were analyzed. Four of the articles highlighted the importance of prevention, three enunciated the importance control and three of them related to care providers’ safety. The results showed that the COVID-19 epidemic has affected the healthcare providers’ health; however, it is possible to prevent a catastrophe through strategic planning, prevention and control measures. Conclusions: Considering the importance of the healthcare workers’ health, it is necessary to implement COVID-19 prevention and control management principles according to scientific evidence.