Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Haplotype-specific assembly of shattered chromosomes in esophageal adenocarcinomas

“…Traditional methods for inferring such selection would rely on finding recurrence of a particular genetic change across independent patient tumors, a well-trodden path for point mutations. 40 , 41 , 42 However, the challenge here is that chromothripsis accesses such a highly combinatorial space of potential genomic configurations that recurrence is exceedingly unlikely to occur. Instead, it may be that inference of positive selection in this setting will have to be done on the phenotypic effect rather than the genomic event, suggesting that studies such as this would need to be scaled to much larger sample sizes.…”

Comprehensive identification and potential application of genetic alteration-driven enhancer RNAs for eRNA-targeted therapy in breast cancer

“… 1 Previous studies have indicated abundant CpG methylation, somatic mutation, and copy number variation in eRNA regions in cancers. 2 , 3 We constructed a landscape of genetic alteration-driven eRNAs and provided an integrative pipeline to identify drug candidates that affect eRNA activity. Furthermore, we explored the prognostic value of genetic alteration-driven eRNAs.…”