Author Correction: Association of Cyclin Dependent Kinase 10 and Transcription Factor 2 during Human Corneal Epithelial Wound Healing in vitro model

Zehra, Meraj; Mushtaq, Shamim; Musharraf, Syed Ghulam; Ghani, Rubina; Ahmed, Nikhat

doi:10.1038/s41598-020-71045-3

Sci Rep

2020

DOI: 10.1038/s41598-020-71045-3

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Author Correction: Association of Cyclin Dependent Kinase 10 and Transcription Factor 2 during Human Corneal Epithelial Wound Healing in vitro model

Meraj Zehra

Shamim Mushtaq

Syed Ghulam Musharraf

et al.

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Identification of hub genes for glaucoma: a study based on bioinformatics analysis and experimental verification

Xie¹,

Xu²

2023

Int J Ophthalmol

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AIM: To explore hub genes for glaucoma based on bioinformatics analysis and an experimental model verification. METHODS: In the Gene Expression Omnibus (GEO) database, the GSE25812 and GSE26299 datasets were selected to analyze differentially expressed genes (DEGs) by the GEO2R tool. Through bioinformatics analysis, 9 hub genes were identified. Receiver operating characteristic (ROC) curves and principal component analysis (PCA) were performed to verify whether the hub gene can distinguish glaucoma from normal eyes. The mouse model of glaucoma was constructed, and the real-time reverse transcriptase-polymerase chain reaction (RT-qPCR) assay was performed to detect the expression levels of hub genes in glaucoma. RESULTS: There were 128 overlapping DEGs in the GSE25812 and GSE26299 datasets, mainly involved in intracellular signalling, cell adhesion molecules and the Ras signalling pathway. A total of 9 hub genes were screened out, including GNAL, BGN, ETS2, FCGP4, MAPK10, MMP15, STAT1, TSPAN8, and VCAM1. The area under the curve (AUC) values of 9 hub genes were greater than 0.8. The PC1 axle could provide a 70.5% interpretation rate to distinguish glaucoma from normal eyes. In the ocular tissues of glaucoma in the mice model, the expression of BGN, ETS2, FCGR4, STAT1, TSPAN8, and VCAM1 was increased, while the expression of GNAL, MAPK10, and MMP15 was decreased. CONCLUSION: Nine hub genes in glaucoma are identified, which may provide new biomarkers and therapeutic targets for glaucoma.

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Identification of hub genes for glaucoma: a study based on bioinformatics analysis and experimental verification

Xie¹,

Xu²

2023

Int J Ophthalmol

View full text Add to dashboard Cite

show abstract

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Author Correction: Association of Cyclin Dependent Kinase 10 and Transcription Factor 2 during Human Corneal Epithelial Wound Healing in vitro model

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Cited by 1 publication

References 0 publications

Identification of hub genes for glaucoma: a study based on bioinformatics analysis and experimental verification

Identification of hub genes for glaucoma: a study based on bioinformatics analysis and experimental verification

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