Author Correction: Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

Martins, Daniel; Mazibuko, Ndaba; Zelaya, Fernando; Vasilakopoulou, S.; Loveridge, Joanna; Oates, Alice; Maltezos, Stefanos; Mehta, Mitul A.; Wastling, Stephen; Howard, Matthew A.; McAlonan, Gráinne; Murphy, Declan; Williams, Steven; Fotopoulou, Aikaterini; Schuschnig, Uwe; Paloyelis, Yannis

doi:10.1038/s41467-022-29419-w

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“…In addition to the conventional nasal spray, an alternative method of administering oxytocin via the nasal passage involves the use of a nebuliser. A nebuliser is purported to improve oxytocin deposition in speci c nasal regions directly implicated in transportation to the brain 24 . Employing this method of delivery could shed more light on the mechanisms involved in nose-to-brain transport, offering more evidence for the nostril-speci c effect.…”

Section: Discussionmentioning

confidence: 99%

Nasal Dominance Potentiates Intranasal Oxytocin’s Anxiolytic Effects

Julius,

Nicholls,

Nowell

et al. 2024

Preprint

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The nasal cycle is a phenomenon whereby alterations in airflow alternate between left and right nostrils. During a nostril’s decongested – or dominant – state, the contralateral nostril is congested, or non-dominant. Intranasal oxytocin may elicit anxiolytic effects. To date, no study has investigated whether there is an optimal nasal pathway for oxytocin’s effects. Forty-four female adolescents aged 16 to 17 years were included in this exploratory study investigating effects of nasal dominance on intranasal oxytocin delivery. We show that intranasal oxytocin significantly reduces stress relative to placebo (p = 0.019, ηp2 = 0.129) and greater stress reduction occurs when oxytocin is delivered to the dominant, rather than non-dominant, nostril (p = 0.045, ηp2 = 0.102). We postulate that oxytocin administration may reduce stress and be most effective in the context of anxiolysis when administered to the dominant nostril. Further research investigating whether other intranasal psychotropic drugs have nostril-specific effects might benefit clinical practice.

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Section: Discussionmentioning

confidence: 99%