Author Correction: Genomic characterization of metastatic breast cancers

Bertucci, François; Ng, Charlotte K.Y.; Patsouris, Anne; Droin, Nathalie; Piscuoglio, Salvatore; Carbuccia, Nadine; Soria, Jean Charles; Dien, Alicia Tran; Adnani, Yahia; Kamal, Maud; Garnier, Séverine; Meurice, Guillaume; Jiménez, Mónica; Doğan, Semih; Verret, Benjamin; Chaffanet, Max; Bachelot, Thomas; Campone, Mario; Lefeuvre, Claudia; Bonnefoi, Hervé; Jacquet, Alexandra; Filippo, Maria Rosaria De; Babbar, Naveen; Birnbaum, Daniel; Filleron, Thomas; Tourneau, Christophe Le; André, Fabrice

doi:10.1038/s41586-019-1380-3

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gene expression profile, the most common form of bioinformatics, is to quantitatively and qualitatively analyze mRNA expression in specific tissues or cells by DNA sequencing, so as to reveal relevant biological mechanisms and provide potential ideas for the treatment and prediction of tumors [ 59 ]. For example, by analyzing somatic changes in 617 cases of metastatic breast cancer, Bertucci et al identified 9 driver genes with higher mutation frequency compared to early-stage breast cancer [ 60 ]. This discovery will provide more standardized guidance for clinical trials.…”

Section: Resultsmentioning

confidence: 99%

The global status of research in breast cancer liver metastasis: a bibliometric and visualized analysis

Shi

Wei

et al. 2021

Bioengineered

View full text Add to dashboard Cite

This study aimed to investigate the distribution laws and research frontiers of international literature, so as to present a holistic bibliometric evaluation of the studies on breast cancer liver metastasis(BCLM). Data were collected from the Web of Science Core Collection database, including publications, year, country, journal, author and keywords. The software VOSviewer and CiteSpace were used for bibliometric coupling, co-authorship, co-citation and co-occurrence analysis. In total, 1,031 publications were analyzed from 2004 to 2020 on BCLM. The year with the highest number of publications was 2006, with 103 papers. The United States, followed by China and Germany were the leading countries on BCLM, accounting for 59% of the whole. The journals that published about BCLM were mainly located in Q1/Q2. Keywords co-occurrence analysis divides BCLM into five clusters:‘basic research’, ‘auxiliary diagnosis and therapy’, ‘liver resection’, ‘clinical trial’ and ‘prognosis’. Main treatment therapies were the latest focus. Burst detection indicated that the trends in BCLM concentrated on subtype and SEER. There is apparently brighter perspective for BCLM research in the coming years, especially in liver resection, subtype and bioinformatics. The consequence of our study as the exclusive scientific evaluation offered an integral overview of BCLM, particularly for research focus and future directions, which can further accurately guide scholars on diagnosis, treatment, and personalized prevention.

show abstract

Section: Resultsmentioning

confidence: 99%

The global status of research in breast cancer liver metastasis: a bibliometric and visualized analysis

Shi

Wei

et al. 2021

Bioengineered

View full text Add to dashboard Cite

show abstract

“…In the ProfiLER study, 78% of samples were archival and >15% of patients had a premature withdrawal because of inadequate samples. 17 In addition, a fresh biopsy should be favored over archival tissue especially in situations when treatment would exert a selective pressure, 25 , 26 in patients who derived initial benefit from targeted therapies, hormone therapies, immunotherapy 27 , 28 or after treatments with mutagenic potential (e.g. temozolomide).…”

Section: The Reasons Behind Failurementioning

confidence: 99%

Precision medicine in the era of multi-omics: can the data tsunami guide rational treatment decision?

Aldea,

Friboulet,

Apcher

et al. 2023

ESMO Open

View full text Add to dashboard Cite

“…MLL3 mutations occur in a variety of human tumors, including hepatocellular carcinoma, colon cancer, bladder cancer, myelodysplastic syndromes, and acute myeloid leukemia (AML) (8)(9)(10). In human breast cancer, the frequency of MLL3 mutations (8.41%) is remarkably higher than those found in other cancer types (11). In addition, in HR + /HER2 − breast cancer, MLL3 mutation rates are higher in metastatic breast cancer than in early breast cancer (12).…”

Section: Introductionmentioning

confidence: 99%

CARM1-mediated methylation of ASXL2 impairs tumor-suppressive function of MLL3/COMPASS

et al. 2022

View full text Add to dashboard Cite

An imbalance in the activities of the Polycomb and Trithorax complexes underlies numerous human pathologies, including cancer. The BRCA1 associated protein-1 (BAP1) deubiquitinase negatively regulates Polycomb activity and recruits the Trithorax histone H3K4 methyltransferase, mixed-lineage leukemia protein 3 (MLL3) within Complex Proteins Associated with Set1 (COMPASS), to the enhancers of tumor suppressor genes. We previously demonstrated that the BAP1-MLL3 pathway is mutated in several cancers, yet how BAP1 recruits MLL3 to its target loci remains an important unanswered question. We demonstrate that the ASXL2 subunit of the BAP1 complex mediates a direct interaction with MLL3/COMPASS. ASXL2 loss results in decreased MLL3 occupancy at enhancers and reduced BAP1-MLL3 target gene expression. Interaction between ASXL2 and MLL3 is negatively regulated by protein arginine methyltransferase 4 (PRMT4/CARM1), which methylates ASXL2 at R639/R641. ASXL2 methylation blocks binding to MLL3 and impairs the expression of MLL3/COMPASS-dependent genes. This previously unidentified transcriptional repressive function of CARM1 provides insight into the BAP1/MLL3-COMPASS axis and reveals a potential cancer therapeutic target.

show abstract

Author Correction: Genomic characterization of metastatic breast cancers

Cited by 4 publications

References 0 publications

The global status of research in breast cancer liver metastasis: a bibliometric and visualized analysis

The global status of research in breast cancer liver metastasis: a bibliometric and visualized analysis

Precision medicine in the era of multi-omics: can the data tsunami guide rational treatment decision?

CARM1-mediated methylation of ASXL2 impairs tumor-suppressive function of MLL3/COMPASS

Contact Info

Product

Resources

About