2021
DOI: 10.1038/s41467-021-23128-6
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Author Correction: Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers

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Cited by 16 publications
(6 citation statements)
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“…The data obtained on the immune response upon application of mRNA vaccines are consistent with former reports, with the majority of samples already above the threshold for seroconversion after one vaccination [ 42 ]. However, after the second vaccination, a robust increase in SARS-CoV-2 IgG concentrations was observed in all participants, a slightly lower response was detected in the senior age group, and a consistent decline from peak values within 5–6 months after vaccination was observed in all participants [ 42 , 43 , 44 , 45 , 46 ]. Notably, two different techniques for SARS-CoV-2 IgG assessment were used and yielded congruent results.…”
Section: Discussionmentioning
confidence: 93%
“…The data obtained on the immune response upon application of mRNA vaccines are consistent with former reports, with the majority of samples already above the threshold for seroconversion after one vaccination [ 42 ]. However, after the second vaccination, a robust increase in SARS-CoV-2 IgG concentrations was observed in all participants, a slightly lower response was detected in the senior age group, and a consistent decline from peak values within 5–6 months after vaccination was observed in all participants [ 42 , 43 , 44 , 45 , 46 ]. Notably, two different techniques for SARS-CoV-2 IgG assessment were used and yielded congruent results.…”
Section: Discussionmentioning
confidence: 93%
“…Early mRNA vaccine studies reported that antibody responses after vaccination were “similar” to persons recovered from COVID-19, , but the level of antibodies from SARS-CoV-2 infection varies greatly depending on the severity of illness and likely wanes over time, , and those studies did not specify the clinical status of the comparison groups. It was unclear to what extent the antibody levels in those COVID-19-recovered persons actually reflect peak levels from severe natural infection, which presumably reflect near-maximal achievable levels.…”
Section: Resultsmentioning
confidence: 99%
“…Finally, the durability of humoral immunity after vaccination is still to be determined. While the waning of antibodies elicited by COVID-19 infection remains controversial, we and others have observed a rapid decay rate in the first few months after infection. , Increasing numbers of reinfections are being reported despite the likelihood that most cases are not diagnosed . Reinfections are the norm for other common human coronaviruses, with infected persons becoming susceptible to reinfection within months after antiviral antibody levels have fallen .…”
mentioning
confidence: 94%
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“…Although SARS-CoV-2–infected individuals may have detectable antibodies present for several months after seroconversion, the temporal persistence of neutralizing antibodies has been shown to decline. 10 , 16 , 17 The immune response of LT recipients to a primary course of COVID-19 vaccination and its relation to immunosuppression use and breakthrough infections has yet to be well reported. In this study, we described the neutralizing antibody responses of LT patients to 2 doses of the BNT162b1 BioNTech vaccination 21 d apart, using the cPass assay.…”
mentioning
confidence: 99%