Author Correction: Regulation of volatile and non-volatile pheromone attractants depends upon male social status

Thoß, Michaela; Luzynski, Kenneth C.; Enk, Viktoria; Razzazi‐Fazeli, Ebrahim; Kwak, Jae; Ortner, Irene; Penn, Dustin J.

doi:10.1038/s41598-019-41666-4

Cited by 3 publications

(3 citation statements)

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“…There is also a strong influence of social environment, whereby males of wild M. m. musculus increase their production of MUPs in the urine when presented with a female behind metal grid (Janotova and Stopka, 2011). Socially induced MUP variation has also been demonstrated in seminatural enclosures, where males doubled the excretion of MUPs after acquiring a territory and became socially dominant (Thoss et al, 2019). Higher concentrations of MUPs may then yield various behavioural responses in the receiver due to MUP detection by VNO neurons via progesterone signalling (Dey et al, 2015).…”

Section: A B Cmentioning

confidence: 98%

Biological Roles of Lipocalins in Chemical Communication, Reproduction, and Regulation of Microbiota

et al. 2021

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Major evolutionary transitions were always accompanied by genetic remodelling of phenotypic traits. For example, the vertebrate transition from water to land was accompanied by rapid evolution of olfactory receptors and by the expansion of genes encoding lipocalins, which – due to their transporting functions – represent an important interface between the external and internal organic world of an individual and also within an individual. Similarly, some lipocalin genes were lost along other genes when this transition went in the opposite direction leading, for example, to cetaceans. In terrestrial vertebrates, lipocalins are involved in the transport of lipophilic substances, chemical signalling, odour reception, antimicrobial defence and background odour clearance during ventilation. Many ancestral lipocalins have clear physiological functions across the vertebrate taxa while many other have – due to pleiotropic effects of their genes – multiple or complementary functions within the body homeostasis and development. The aim of this review is to deconstruct the physiological functions of lipocalins in light of current OMICs techniques. We concentrated on major findings in the house mouse in comparison to other model taxa (e.g., voles, humans, and birds) in which all or most coding genes within their genomes were repeatedly sequenced and their annotations are sufficiently informative.

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Section: A B Cmentioning

confidence: 98%

Biological Roles of Lipocalins in Chemical Communication, Reproduction, and Regulation of Microbiota

et al. 2021

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“…These signals are detected mainly by the vomeronasal organ and project to the accessory olfactory bulb where they have stable representations within neural circuits ( 40 , 41 ). Urine serves as landmarks with sustained release of VOCs ( 42 , 43 ), while in direct contact with individuals, orofacial and anogenital areas are explored during the first encounter ( 24 , 44 ). For males, assessing the receptive phase of the female reproductive cycle is an important ability that increases their fitness via reproductive success.…”

Section: Introductionmentioning

confidence: 99%

Microbial, proteomic, and metabolomic profiling of the estrous cycle in wild house mice

Matějková,

Dodoková,

Kreisinger

et al. 2024

Microbiol Spectr

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Symbiotic microbial communities affect the host immune system and produce molecules contributing to the odor of an individual. In many mammalian species, saliva and vaginal fluids are important sources of chemical signals that originate from bacterial metabolism and may act as honest signals of health and reproductive status. In this study, we aimed to define oral and vaginal microbiomes and their dynamics throughout the estrous cycle in wild house mice. In addition, we analyzed a subset of vaginal proteomes and metabolomes to detect potential interactions with microbiomes. 16S rRNA sequencing revealed that both saliva and vagina are dominated by Firmicutes and Proteobacteria but differ at the genus level. The oral microbiome is more stable during the estrous cycle and most abundant bacteria belong to the genera Gemella and Streptococcus , while the vaginal microbiome shows higher bacterial diversity and dynamics during the reproductive cycle and is characterized by the dominance of Muribacter and Rodentibacter . These two genera cover around 50% of the bacterial community during estrus. Proteomic profiling of vaginal fluids revealed specific protein patterns associated with different estrous phases. Highly expressed proteins in estrus involve the keratinization process thus providing estrus markers (e.g., Hrnr) while some proteins are downregulated such as immune-related proteins that limit bacterial growth (Camp, Clu, Elane, Lyz2, and Ngp). The vaginal metabolome contains volatile compounds potentially involved in chemical communication, for example, ketones, aldehydes, and esters of carboxylic acids. Data integration of all three OMICs data sets revealed high correlations, thus providing evidence that microbiomes, host proteomes, and metabolomes may interact. IMPORTANCE Our data revealed dynamic changes in vaginal, but not salivary, microbiome composition during the reproductive cycle of wild mice. With multiple OMICs platforms, we provide evidence that changes in microbiota in the vaginal environment are accompanied by changes in the proteomic and metabolomics profiles of the host. This study describes the natural microbiota of wild mice and may contribute to a better understanding of microbiome-host immune system interactions during the hormonal and cellular changes in the female reproductive tract. Moreover, analysis of volatiles in the vaginal fluid shows particular substances that can be involved in chemical communication and reproductive behavior.

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“…Mate preference and copulatory behavior are based on pheromones and synchronized with ovulation to ensure reproductive success in female rodents (Hellier et al, 2018). Exposure of a mixture of male mice pheromones to female mice triggers female olfactory preferences and speeds up the vaginal opening (Thoß et al, 2019). Karlson and Luscher in 1959 define pheromone as a volatile chemical that is tiny (5 to 17 of carbon atoms), either signalling or releasing (immediate response) or priming type (response takes a long time to occur), generated by a species that influences the same species' behavior or physiology.…”

Section: Introductionmentioning

confidence: 99%

Determination of the whitten effect based on vaginal cell characteristics, vulva appearance and behavior in grouped female mice

Zakaria

Sukardi

2019

LSMB

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Introduction: Pheromones are chemicals produced by an animal that affects the behavior of another animal or the same species. Information conveyed includes location, presence of food or threat, sexual attraction, courtship, and dam-pup interactions. Pheromones are used widely in laboratory mice facilities to synchronize estrus and simultaneous breeding for logistic purposes. Female mice housed together in the absence of the male exhibit the Lee-Boot effect of lengthened diestrus or ovarian inactive period of up to several weeks. Whitten effect is described when a large number of female mice housed together in the absence of the male and having diestrus, will enter estrous 48 to 72 hours later upon exposure to male odors or male mouse urine soaked-bedding. Objective: The aim of this study is to determine the time taken for the Whitten effect to occur based on changes in vaginal cell characteristics, vulva appearance and behavior in grouped female mice. Methodology: Ten female mice were acclimatized to the animal facility for 3 estrus cycles or 12 days. Phases of the estrus cycle were evaluated by visual observation to assess changes to the vulva and vaginal cytology. Male urine soaked-bedding were exposed to females for 3 days and the time taken for the Whitten effect to occur was determined based on changes in vaginal cell characteristics, vulva appearance and observation of behavior. Result: The Cochran's Q test was used to observe the changes from diestrus to proestrus and later estrus. The results showed a significant difference (p<0.05) in the number of mice that successfully enter the proestrus and estrus phases over a four time point, χ 2 (2) = 18.857. Conclusion: The Whitten effect occurs after 72 hours of exposure to male urine soaked-bedding based on vulva appearance, vaginal cell characteristics and behavior in grouped female mice.

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Author Correction: Regulation of volatile and non-volatile pheromone attractants depends upon male social status

Cited by 3 publications

References 0 publications

Biological Roles of Lipocalins in Chemical Communication, Reproduction, and Regulation of Microbiota

Biological Roles of Lipocalins in Chemical Communication, Reproduction, and Regulation of Microbiota

Microbial, proteomic, and metabolomic profiling of the estrous cycle in wild house mice

Determination of the whitten effect based on vaginal cell characteristics, vulva appearance and behavior in grouped female mice

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