Author Correction: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

Qiao, Wei; Lau, Hui En; Xie, Hujun; Poon, Vincent Kwok-Man; Chan, Chris; Chu, Hin; Yuan, Shuofeng; Yuen, Terrence Tsz‐Tai; Chik, Kenn Ka-Heng; Tsang, Jessica Oi-Ling; Chan, Chris Chun-Yiu; Cai, Jian‐Piao; Luo, Cheng; Yuen, Kwok‐Yung; Cheung, Kenneth M.C.; Chan, Jasper Fuk‐Woo; Yeung, Kelvin Wai Kwok

doi:10.1038/s41467-022-30952-x

Cited by 7 publications

(4 citation statements)

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“…187,188 A recent study characterized the effects of SARS-CoV-2 infection on bone metabolism in the acute and post-recovery periods in an animal model. 182 The microcomputerized tomography (μCT) and histological analysis of golden Syrian hamsters showed an early and progressive bone loss particularly in the trabecular component in terms of bone volume (–50% than noninfected hamsters), density and trabecular thickness, and number at the distal femur and proximal tibia from 4 days after infection to post-acute (1 month), and the recovery phase (2 months), while cortical component was poorly affected. The same skeletal alterations were detected in the lumbar vertebrae at 1 month, and bone density did not improve during the recovery period (2 months).…”

Section: Bone Damage Due To the Covid-19 Pandemicmentioning

confidence: 99%

Section: Bone Damage Due To Sars-cov-2 Infectionmentioning

confidence: 99%

“…On the other side, severe COVID-19 commonly affects older people and patients with comorbidities, on corticosteroid and immunosuppressive therapy, therefore, the identification of COVID-19-related bone damage in these patients is challenging. 182 Metabolic bone disorder can be observed in chronic inflammatory diseases, such as chronic obstructive pulmonary disease (COPD), 183 and the degree of inflammatory response is associated with bone loss that persists even if the inflammatory disease is well treated. 184 In COVID-19, it has been demonstrated that the inflammatory patterns are closely correlated with the clinical manifestations, so that, severe diseases are characterized by higher serum pro-inflammatory cytokines than mild COVID-19 (‘cytokine storm’).…”

Section: Bone Damage Due To the Covid-19 Pandemicmentioning

confidence: 99%

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Bone fragility during the COVID-19 pandemic: the role of macro- and micronutrients

Moretti

Liguori

Paoletta

et al. 2023

Therapeutic Advances in Musculoskeletal

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Bone fragility is the susceptibility to fracture due to poor bone strength. This condition is usually associated with aging, comorbidities, disability, poor quality of life, and increased mortality. International guidelines for the management of patients with bone fragility include a nutritional approach, mainly aiming at optimal protein, calcium, and vitamin D intakes. Several biomechanical features of the skeleton, such as bone mineral density (BMD), trabecular and cortical microarchitecture, seem to be positively influenced by micro- and macronutrient intake. Patients with major fragility fractures are usually poor consumers of dairy products, fruit, and vegetables as well as of nutrients modulating gut microbiota. The COVID-19 pandemic has further aggravated the health status of patients with skeletal fragility, also in terms of unhealthy dietary patterns that might adversely affect bone health. In this narrative review, we discuss the role of macro- and micronutrients in patients with bone fragility during the COVID-19 pandemic.

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Section: Bone Damage Due To the Covid-19 Pandemicmentioning

confidence: 99%

Section: Bone Damage Due To Sars-cov-2 Infectionmentioning

confidence: 99%

Section: Bone Damage Due To the Covid-19 Pandemicmentioning

confidence: 99%

See 1 more Smart Citation

Bone fragility during the COVID-19 pandemic: the role of macro- and micronutrients

Moretti

Liguori

Paoletta

et al. 2023

Therapeutic Advances in Musculoskeletal

View full text Add to dashboard Cite

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“…As a trigger of the immune-mediated mechanisms that could affect bone quality, increasing studies have demonstrated the relationships between low bone mineral density and infections by viruses including human immunodeficiency virus (HIV) [10], hepatitis B virus (HBV) [10,11], hepatitis C virus (HCV) [10], herpes zoster virus (VZV) [12], and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections [13,14]. For instance, HIV infections were found to elevate the B cell receptor activator of nuclear factor kappa-B ligand (RANKL) and diminish osteo-protegerin, which drives bone resorption [10].…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus Infections and Increased Risk of Incident Osteoporosis: A Nationwide Population-Based Cohort Study

Chin

et al. 2023

Viruses

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Patients with viral infections are susceptible to osteoporosis. This cohort study investigated the correlation between human papillomavirus (HPV) infections and the risk of osteoporosis via 12,936 patients with new-onset HPV infections and propensity score-matched non-HPV controls enrolled in Taiwan. The primary endpoint was incident osteoporosis following HPV infections. Cox proportional hazards regression analysis and the Kaplan-Meier method was used to determine the effect of HPV infections on the risk of osteoporosis. Patients with HPV infections presented with a significantly high risk of osteoporosis (adjusted hazard ratio, aHR = 1.32, 95% CI = 1.06–1.65) after adjusting for sex, age, comorbidities and co-medications. Subgroup analysis provided that populations at risk of HPV-associated osteoporosis were females (aHR = 1.33; 95% CI = 1.04–1.71), those aged between 60 and 80 years (aHR = 1.45, 95% CI = 1.01–2.08 for patients aged 60–70; aHR = 1.51; 95% CI = 1.07–2.12 for patients aged 70–80), and patients with long-term use of glucocorticoids (aHR = 2.17; 95% CI = 1.11–4.22). HPV-infected patients who did not receive treatments for HPV infections were at a greater risk (aHR = 1.40; 95% CI = 1.09–1.80) of osteoporosis, while the risk of osteoporosis in those who received treatments for HPV infections did not reach statistical significance (aHR = 1.14; 95% CI = 0.78–1.66). Patients with HPV infections presented with a high risk of subsequent osteoporosis. Treatments for HPV infections attenuated the risk of HPV-associated osteoporosis.

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The Impacts of COVID-19 on Musculoskeletal Health

Awosanya

Dadwal

Imel

et al. 2022

Curr Osteoporos Rep

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Purpose of Review Although COVID-19 was originally characterized as a respiratory disease, recent findings have shown lingering side effects in those who have recovered, and much is still unknown about the long-term consequences of the illness. Thus, the potential of unearthing multi-system dysfunction is high, with current data revealing significant impacts on musculoskeletal health. Recent Findings Multiple animal models of COVID-19 infection have revealed significant post-infection bone loss at several different skeletal sites. While how this loss occurred is unknown, this current review discusses the primary bone loss studies, and examines the possible mechanisms of action including: direct infection of bone marrow macrophages or hematopoietic progenitors, a proinflammatory response as a result of the COVID-19 induced cytokine storm, and/or a result of hypoxia and oxidative stress. This review will further examine how therapeutics used to treat COVID-19 affect the skeletal system. Finally, this review will examine the possible consequence that delayed care and limited healthcare accessibility has on musculoskeletal-related patient outcomes. Summary It is important to investigate the potential impact COVID-19 infection has on musculoskeletal health.

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Author Correction: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

Cited by 7 publications

References 0 publications

Bone fragility during the COVID-19 pandemic: the role of macro- and micronutrients

Bone fragility during the COVID-19 pandemic: the role of macro- and micronutrients

Human Papillomavirus Infections and Increased Risk of Incident Osteoporosis: A Nationwide Population-Based Cohort Study

The Impacts of COVID-19 on Musculoskeletal Health

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