Author Correction: Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection

Adland, Emily; Millar, Jane; Bengu, Nomonde; Muenchhoff, Maximilian; Fillis, Rowena; Sprenger, Ken; Ntlantsana, Vuyokazi; Roider, Julia; Vieira, Vinícius; Govender, Katya; Adamson, John; Nxele, Nelisiwe; Ochsenbauer, Christina; Kappes, JC; Mori, Luisa; Lobenstein, Jeroen van; Graza, Y; Chinniah, Kogielambal; Kapongo, Constant; Bhoola, R; Krishna, Malini; Matthews, Philippa C.; Poderos, Ruth Penya; Lluch, Marta Colomer; Puertas, Maria C.; Prado, Julia G.; McKerrow, Neil; Archary, Moherndran; Ndung’u, Thumbi; Groll, Andreas; Jooste, Pieter; Martínez-Picado, Javier; Altfeld, Marcus; Goulder, Philip

doi:10.1038/s41467-020-16215-7

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“…Female infants are reported to have two- to three-fold increased risk of infection at birth compared to male infants ( 7 , 140 , 141 ). This increased susceptibility has been linked to subversion of innate immunity, with female fetuses acquiring maternal variants resistant to type I interferons ( 142 ). Sex-specific differences in in utero infection have also been attributed to the fact that in utero mortality rates of HIV-infected male infants are disproportionately higher and thus more HIV-infected female infants are liveborn.…”

Section: Factors Influencing Vertical Transmissionmentioning

confidence: 99%

Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure

et al. 2021

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Despite the significant progress that has been made to eliminate vertical HIV infection, more than 150,000 children were infected with HIV in 2019, emphasizing the continued need for sustainable HIV treatment strategies and ideally a cure for children. Mother-to-child-transmission (MTCT) remains the most important route of pediatric HIV acquisition and, in absence of prevention measures, transmission rates range from 15% to 45% via three distinct routes: in utero, intrapartum, and in the postnatal period through breastfeeding. The exact mechanisms and biological basis of these different routes of transmission are not yet fully understood. Some infants escape infection despite significant virus exposure, while others do not, suggesting possible maternal or fetal immune protective factors including the presence of HIV-specific antibodies. Here we summarize the unique aspects of HIV MTCT including the immunopathogenesis of the different routes of transmission, and how transmission in the antenatal or postnatal periods may affect early life immune responses and HIV persistence. A more refined understanding of the complex interaction between viral, maternal, and fetal/infant factors may enhance the pursuit of strategies to achieve an HIV cure for pediatric populations.

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Section: Factors Influencing Vertical Transmissionmentioning

confidence: 99%

Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure

et al. 2021

View full text Add to dashboard Cite

show abstract

Author Correction: Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Cited by 1 publication

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Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure

Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure

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