Author Correction: Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

Werba, Gregor; Weissinger, Daniel; Kawaler, Emily; Zhao, Ende; Kalfakakou, Despoina; Dhara, Surajit; Wang, Lidong; Lim, Heather B.; Oh, Grace; Jing, Xiaohong; Beri, Nina; Khanna, Lauren G.; Gonda, Tamas A.; Oberstein, Paul E.; Hajdu, Cristina; Loomis, Cynthia A.; Heguy, Adriana; Sherman, Mara H.; Lund, Amanda W.; Welling, Theodore H.; Dolgalev, Igor; Tsirigos, Aristotelis; Simeone, Diane M.

doi:10.1038/s41467-023-39680-2

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2024

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Cited by 3 publications

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“…Previous work has defined inflammatory CAFs with different markers. 21 , 39 , 55 , 57 Also, matrix-associated CAFs have been described in the literature as having high expression of MMP11 and collagens. 17 , 36 , 54 , 55 In our study, we distinguished between mCAFs (FAP + MMP11 + ) and collagen CAFs (FAP + MMP11 - ), with the latter cells likely to be a subgroup within the diverse group of matrix-associated CAFs, 17 , 34 but that express matrix deposition and remodeling factors other than MMP11.…”

Section: Discussionmentioning

confidence: 99%

Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer

Cords,

Engler,

Haberecker

et al. 2024

Cancer Cell

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Section: Discussionmentioning

confidence: 99%

Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer

Cords,

Engler,

Haberecker

et al. 2024

Cancer Cell

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Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches

Chen,

Zhou,

Yazgan

et al. 2024

Preprint

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Recent studies have identified a unique subtype of cancer-associated fibroblasts (CAFs) termed antigen-presenting CAFs (apCAFs), which remain the least understood CAF subtype. To gain a comprehensive understanding of the origin and function apCAFs, we construct a fibroblast molecular atlas across 14 types of solid tumors. Our integration study unexpectedly reveals two distinct apCAF lineages present in most cancer types: one associated with mesothelial-like cells and the other with fibrocytes. Using a high-resolution single-cell spatial imaging platform, we characterize the spatial niches of these apCAF lineages. We find that mesothelial-like apCAFs are located near cancer cells, while fibrocyte-like apCAFs are associated with tertiary lymphoid structures. Additionally, we discover that both apCAF lineages can up-regulate the secreted protein SPP1, which facilitates primary tumor formation and peritoneal metastasis. Taken together, this study offers an unprecedented resolution in analyzing apCAF lineages and their spatial niches.

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Pancreatic stellate cells and the interleukin family: Linking fibrosis and immunity to pancreatic ductal adenocarcinoma (Review)

Li,

Liu,

et al. 2024

Mol Med Rep

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Author Correction: Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

Cited by 3 publications

References 0 publications

Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer

Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer

Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches

Pancreatic stellate cells and the interleukin family: Linking fibrosis and immunity to pancreatic ductal adenocarcinoma (Review)

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