Author Correction: Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis

Ferrándiz, Nuria; Barroso, Consuelo; Telecan, Oana; Shao, Nan; Kim, Hyun‐Min; Testori, Sarah; Faull, Peter; Cutillas, Pedro R.; Snijders, Ambrosius P.; Colaiácovo, Mónica P.; Martínez-Pérez, Enrique

doi:10.1038/s41467-018-05848-4

Cited by 2 publications

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“…On the other hand, molecular events affecting the expression/regulation/stability of cohesin complex components at the gene or protein level may compromise LAB-1 and AIR-2 bivalent association in late diakinesis, as the association of these proteins to chromosomes is unaffected at earlier stages of chromosome remodeling. Alternatively, defects impinging on HTP-1 and HTP-2 expression or function may preclude maintenance of LAB-1 chromosomal association [68,69]. In either case, cohesin-independent linkages could maintain sister chromatid cohesion despite the absence of LAB-1.…”

Section: Dehp-induced Chromosome Morphology Defects In Late Diakinesimentioning

confidence: 99%

Environmentally-relevant exposure to diethylhexyl phthalate (DEHP) alters regulation of double-strand break formation and crossover designation leading to germline dysfunction in Caenorhabditis elegans

et al. 2020

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Exposure to diethylhexyl phthalate (DEHP), the most abundant plasticizer used in the production of polyvinyl-containing plastics, has been associated to adverse reproductive health outcomes in both males and females. While the effects of DEHP on reproductive health have been widely investigated, the molecular mechanisms by which exposure to environmentally-relevant levels of DEHP and its metabolites impact the female germline in the context of a multicellular organism have remained elusive. Using the Caenorhabditis elegans germline as a model for studying reprotoxicity, we show that exposure to environmentallyrelevant levels of DEHP and its metabolites results in increased meiotic double-strand breaks (DSBs), altered DSB repair progression, activation of p53/CEP-1-dependent germ cell apoptosis, defects in chromosome remodeling at late prophase I, aberrant chromosome morphology in diakinesis oocytes, increased chromosome non-disjunction and defects during early embryogenesis. Exposure to DEHP results in a subset of nuclei held in a DSB permissive state in mid to late pachytene that exhibit defects in crossover (CO) designation/ formation. In addition, these nuclei show reduced Polo-like kinase-1/2 (PLK-1/2)-dependent phosphorylation of SYP-4, a synaptonemal complex (SC) protein. Moreover, DEHP exposure leads to germline-specific change in the expression of prmt-5, which encodes for an arginine methyltransferase, and both increased SC length and altered CO designation levels on the X chromosome. Taken together, our data suggest a model by which impairment of a PLK-1/2-dependent negative feedback loop set in place to shut down meiotic DSBs, together with alterations in chromosome structure, contribute to the formation of an excess number of DSBs and altered CO designation levels, leading to genomic instability.

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Section: Dehp-induced Chromosome Morphology Defects In Late Diakinesimentioning

confidence: 99%

Environmentally-relevant exposure to diethylhexyl phthalate (DEHP) alters regulation of double-strand break formation and crossover designation leading to germline dysfunction in Caenorhabditis elegans

et al. 2020

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“…The aurora B kinase assembles along the short arms, forming a large “midbivalent ring” between the kinetochore cups ( Dumont et al, 2010 ; Kaitna et al, 2002 ; Rogers et al, 2002 ; Wignall and Villeneuve, 2009 ). Aurora B kinase mediates separase cleavage of short-arm cohesin and homolog separation at anaphase I ( Ferrandiz et al, 2018a ; Rogers et al, 2002 ). At anaphase onset, there is no apparent kinetochore protein on the inner face of separating homologs, raising the question of how microtubules might be attached to the inner face of chromosomes as suggested by Laband et al (2017) .…”

Section: Introductionmentioning

confidence: 99%

Evidence for anaphase pulling forces duringC. elegansmeiosis

Danlasky

Panzica

McNally

et al. 2020

Journal of Cell Biology

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Anaphase chromosome movement is thought to be mediated by pulling forces generated by end-on attachment of microtubules to the outer face of kinetochores. However, it has been suggested that during C. elegans female meiosis, anaphase is mediated by a kinetochore-independent pushing mechanism with microtubules only attached to the inner face of segregating chromosomes. We found that the kinetochore proteins KNL-1 and KNL-3 are required for preanaphase chromosome stretching, suggesting a role in pulling forces. In the absence of KNL-1,3, pairs of homologous chromosomes did not separate and did not move toward a spindle pole. Instead, each homolog pair moved together with the same spindle pole during anaphase B spindle elongation. Two masses of chromatin thus ended up at opposite spindle poles, giving the appearance of successful anaphase.

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Author Correction: Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis

Abstract: The original version of this Article contained an error in the spelling of the author Ambrosius P. Snijders, which was incorrectly given as Ambrosious P. Snijders. This has now been corrected in both the PDF and HTML versions of the Article.

Cited by 2 publications

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Environmentally-relevant exposure to diethylhexyl phthalate (DEHP) alters regulation of double-strand break formation and crossover designation leading to germline dysfunction in Caenorhabditis elegans

Environmentally-relevant exposure to diethylhexyl phthalate (DEHP) alters regulation of double-strand break formation and crossover designation leading to germline dysfunction in Caenorhabditis elegans

Evidence for anaphase pulling forces duringC. elegansmeiosis

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